A5029383178- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- Forensic and Genetic Research
- Colorectal Cancer Treatments and Studies
- Genetic Neurodegenerative Diseases
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Machine Learning in Bioinformatics
- Gene expression and cancer classification
- Hereditary Neurological Disorders
- Carcinogens and Genotoxicity Assessment
- Genomics and Rare Diseases
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Long-Term Effects of COVID-19
Universidad de Las Américas
2011-2025
University of the Americas
2023-2024
Universidad Internacional SEK
2022
Universidad UTE
2017-2021
Facultad Latinoamericana de Ciencias Sociales
2020-2021
Universidade da Coruña
2019-2021
Artistic Realization Technologies
2014
Pontificia Universidad Católica del Ecuador
2008
The SARS-CoV-2 virus has spread rapidly around the globe. Nevertheless, there is limited information describing characteristics and outcomes of COVID-19 patients in Latin America. We conducted a cross-sectional analysis 9,468 confirmed cases reported Ecuador. calculated overall incidence, mortality, case fatality rates, disability adjusted life years, attack crude mortality as well relative risk odds death, for age, sex presence comorbidities. A total positive 474 deaths were included...
Abstract Over the past decades, consistent studies have shown that race/ethnicity a great impact on cancer incidence, survival, drug response, molecular pathways and epigenetics. Despite influence of in outcomes its health care quality, comprehensive understanding racial/ethnic inclusion oncological research has never been addressed. We therefore explored composition samples/individuals included fundamental (patient-derived models, biobanks genomics) applied (clinical trials). Regarding...
Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans. The current classification coronaviruses recognizes 39 species 27 subgenera belong to the Coronaviridae. From those, at least seven known respiratory infections Four these common cold-like symptoms, while others infect evolve become infectious Three recent examples this viral jumps include SARS CoV, MERS-CoV CoV-2 virus. They responsible for causing severe acute syndrome (SARS), Middle East...
E-cigarettes are often marketed as a less harmful alternative to traditional tobacco cigarettes. Despite their popularity, the evidence regarding effects on human health remains unclear and is filled with complexities.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with highest incidence worldwide. HNSCC often diagnosed at advanced stages, incurring significant high mortality morbidity. The use of saliva, as a noninvasive tool for diagnosis cancer, has recently increased. Salivary microRNAs (miRNAs) have emerged promising molecular early HNSCC. aim was to identify differential expression salivary miRNAs associated in altitude mestizo Ecuadorian population. Using PCR Arrays,...
Wuhan, China was the epicenter of first zoonotic transmission severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) in December 2019 and it is causative agent novel human disease (COVID-19). Almost from beginning COVID-19 outbreak several attempts were made to predict possible drugs capable inhibiting virus replication. In present work a drug repurposing study performed identify potential SARS-CoV-2 protease inhibitors. We created Quantitative Structure–Activity Relationship...
Abstract Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein expression deregulation, signaling pathway hormone disruption, ethnicity and environmental determinants are involved. Due to the complexity of BC, prediction proteins involved in this trending topic drug design. This work proposing accurate classifier for BC using six sets sequence descriptors 13 machine-learning methods. After univariate feature selection mix five descriptor families, best was obtained...
Abstract The history of Ecuador was marked by the arrival Europeans with Africans, resulting in mixture Native Americans Africans and Europeans. present study contributes to knowledge Ecuadorian mestizo population offering information about ancestry ethnic heterogeneity. Forty-six AIM-InDels (Ancestry Informative Insertion/Deletion Markers) were used obtain on 240 individuals from three regions (Amazonia, Highlands, Coast). As a result, involved significant contribution (values up 51%),...
Breast cancer (BC) is the leading cause of cancer-related death among women and most commonly diagnosed worldwide. Although in recent years large-scale efforts have focused on identifying new therapeutic targets, a better understanding BC molecular processes required. Here we elucidating hallmarks heterogeneity oncogenic mutations involved precision medicine that remains poorly defined. To fill this gap, established an OncoOmics strategy consists analyzing genomic alterations, signaling...
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
Alternative Lengthening of Telomeres (ALT) is a telomerase-independent mechanism deployed by several aggressive cancers to maintain telomere length. This contributes their malignancy and resistance conventional therapies. In prior studies, we have identified key proteins linked the ALT process using multi-omic data integration strategies. this work, combined metabolomic datasets with our earlier results identify targetable metabolic pathways for ALT-positive tumors. 39 ALT-related were found...
Abstract Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, main objective this study apply theoretical approaches explore genes and communities directly involved breast cancer (BC) pathogenesis. We evaluated consensus between 8 prioritization strategies for early pathogenic genes. A communality analysis protein-protein interaction (PPi) network previously selected enriched with gene ontology, metabolic pathways, as well...
Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field chronobiology has increased our understanding how rhythm disturbances contribute to cancer pathogenesis, circadian timing influences the efficacy treatments. As clock steadily gains recognition as an emerging factor in...
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014. Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR (MTRR) are enzymes that play an important role folate metabolism. The single nucleotide polymorphisms, MTHFR C677T, A1298C, A2756G, MTRR A66G, alter plasmatic homocysteine concentrations, causing problems during repairment, synthesis, methylation genetic material. Therefore, it essential to know how BC risk associated with...
Breast cancer is the leading cause of cancer-related death among women worldwide. AKT1 encodes kinase B alpha protein. The rs121434592, rs12881616, rs11555432, rs11555431, rs2494732, and rs3803304 single nucleotide polymorphisms have been identified in gene. Activated phosphorylates downstream substrates regulating cell growth, metabolism, apoptosis, angiogenesis, drug responses. It essential to know how breast risk associated with histopathological immunohistochemical characteristics...
Abstract Background The relentless advance of the SARS-CoV-2 virus pandemic has resulted in a significant burden on countries, regardless their socio-economic conditions. infected more than 2.5 million people worldwide, causing to date 150,000 deaths over 210 countries. Objective aim this study was describe trends cases, tests and related novel coronavirus disease (COVID-19) Latin American Caribbean (LAC) Methodology Data were retrieved from WHO-Coronavirus Disease (COVID-2019) situation...