A5089354223- HIV Research and Treatment
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- SARS-CoV-2 and COVID-19 Research
- E-Government and Public Services
- Computational Drug Discovery Methods
- Forensic and Genetic Research
- Regional Development and Innovation
- Herpesvirus Infections and Treatments
- Sustainable Agricultural Systems Analysis
- Hereditary Neurological Disorders
- Public Policy and Administration Research
- Bioinformatics and Genomic Networks
- Community Development and Social Impact
- Molecular Biology Techniques and Applications
- Business, Innovation, and Economy
- Cancer-related molecular mechanisms research
- Artificial Intelligence in Healthcare and Education
- Genomics and Rare Diseases
Universidad Internacional del Ecuador
2021-2025
Universidad Católica del Uruguay
2024
University of Quindío
2023
Centre for Genomic Regulation
2016-2022
University at Albany, State University of New York
2009-2022
Organisation de Coopération et de Développement Economiques
2018-2022
Halliburton (United Kingdom)
2022
Universidade da Coruña
2022
Centre National de la Recherche Scientifique
2012-2021
Hospital São Vicente
2021
We argue that the Obama Administration's Open Government Initiative blurs distinctions between e-democracy and e-government by incorporating historically democratic practices, now enabled emerging technology, within administrative agencies. consider nature of transparency, par ticipation, collaboration, suggesting these processes should be viewed as means toward desirable ends, rather than ends in themselves, they appear to currently treated. propose alternatively planning OG initiatives...
Abstract Over the past decades, consistent studies have shown that race/ethnicity a great impact on cancer incidence, survival, drug response, molecular pathways and epigenetics. Despite influence of in outcomes its health care quality, comprehensive understanding racial/ethnic inclusion oncological research has never been addressed. We therefore explored composition samples/individuals included fundamental (patient-derived models, biobanks genomics) applied (clinical trials). Regarding...
We consider open government (OG) within the context of e-government and its broader implications for future public administration. argue that current US Administration's Open Government Initiative blurs traditional distinctions between e-democracy by incorporating historically democratic practices, now enabled emerging technology, administrative agencies. how transparency, participation, collaboration function as practices in agencies, suggesting these processes are instrumental attributes...
Identification of marker genes expressed in specific cell types is essential for the genetic dissection neural circuits. Here we report a new strategy classifying heterogeneous populations neurons into functionally distinct and identifying associated genes. Quantitative single-cell expression profiling related to neurotransmitters ion channels enables functional classification neurons; transcript profiles gene candidates identify molecular handles manipulating each type. We apply this mouse...
Abstract While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play central roles in RNA regulation, including translation and turnover. Here we show that protein CSDE1 (cold shock domain containing E1) highly expressed hESCs to maintain their undifferentiated state prevent default neural fate. Notably, loss accelerates...
Abstract Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein expression deregulation, signaling pathway hormone disruption, ethnicity and environmental determinants are involved. Due to the complexity of BC, prediction proteins involved in this trending topic drug design. This work proposing accurate classifier for BC using six sets sequence descriptors 13 machine-learning methods. After univariate feature selection mix five descriptor families, best was obtained...
Abstract The history of Ecuador was marked by the arrival Europeans with Africans, resulting in mixture Native Americans Africans and Europeans. present study contributes to knowledge Ecuadorian mestizo population offering information about ancestry ethnic heterogeneity. Forty-six AIM-InDels (Ancestry Informative Insertion/Deletion Markers) were used obtain on 240 individuals from three regions (Amazonia, Highlands, Coast). As a result, involved significant contribution (values up 51%),...
Breast cancer (BC) is the leading cause of cancer-related death among women and most commonly diagnosed worldwide. Although in recent years large-scale efforts have focused on identifying new therapeutic targets, a better understanding BC molecular processes required. Here we elucidating hallmarks heterogeneity oncogenic mutations involved precision medicine that remains poorly defined. To fill this gap, established an OncoOmics strategy consists analyzing genomic alterations, signaling...
Alternative Lengthening of Telomeres (ALT) is a telomerase-independent mechanism deployed by several aggressive cancers to maintain telomere length. This contributes their malignancy and resistance conventional therapies. In prior studies, we have identified key proteins linked the ALT process using multi-omic data integration strategies. this work, combined metabolomic datasets with our earlier results identify targetable metabolic pathways for ALT-positive tumors. 39 ALT-related were found...
Cold-inducible RNA binding protein (CIRBP) is a stress-responsive that promotes cancer development and inflammation. Critical to most CIRBP functions its capacity bind posttranscriptionally modulate mRNA. However, transcriptome-wide analysis of mRNA targets in has not yet been performed. Here, we use an ex vivo breast model identify mechanisms. We find transcript levels correlate with subtype are indicator luminal A/B prognosis. Accordingly, overexpression nontumoral MCF-10A cells cell...
Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field chronobiology has increased our understanding how rhythm disturbances contribute to cancer pathogenesis, circadian timing influences the efficacy treatments. As clock steadily gains recognition as an emerging factor in...
Electronic laboratory notebooks (ELNs) will probably replace paper (PLNs) in academic research due to their advantages data recording, sharing and security. Despite several reports describing technical characteristics of ELNs over PLNs, no study has directly tested ELN performance among researchers. In addition, the usage tablet-based devices or wearable technology as complements never been explored field. To implement an our biomedical institute, here we first present a comparison six using...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
PURPOSE Ethnic diversity in cancer research is crucial as race/ethnicity influences incidence, survival, drug response, molecular pathways, and epigenetic phenomena. In 2018, we began a project to examine racial/ethnic research, with commitment review these disparities every 4 years. This report our second assessment, detailing the present state of genomics clinical trials. METHODS To study inclusion genomics, extracted ethnic records from all data sets available at cBioPortal (n = 125,128...
Abstract This study examines farmers’ preferences for practice-based, result-based and hybrid agri-environmental schemes in three countries through a choice experiment conducted by the Organization Economic Cooperation Development, focusing on biodiversity, climate water quality. The results reveal that, general, farmers tend to prefer practice-based quality or change mitigation goals over schemes. Moreover, indicates that only limited number of are both preferred more socially beneficial...
This paper addresses and discusses the central issues that researchers have to deal with when conducting cross-national comparative research within area of e-government. The are classified into two main categories. first category represents challenges may affect reliability quality data being collected for studies. second remaining related objective, selection process countries analytical strategy. major alternatives these provides a rationale among them. concludes by discussing...
Abstract The essential HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells expressing cytidine deaminases APOBEC3G (A3G) and A3F by decreasing their cellular level, preventing incorporation into virions. Unlike the Vif-induced degradation A3G, functional role inhibition A3G translation Vif remained unclear. Here, we show that two stem-loop structures within 5′-untranslated region mRNA are crucial for in cells, most alleles neutralize efficiently....