A5030281278- SARS-CoV-2 and COVID-19 Research
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- Nanoparticles: synthesis and applications
- Microbial Metabolic Engineering and Bioproduction
- Photosynthetic Processes and Mechanisms
- Insect and Pesticide Research
- Probiotics and Fermented Foods
- Botanical Research and Applications
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Diagnosis and treatment of tuberculosis
- Plant Reproductive Biology
- COVID-19 diagnosis using AI
- Amoebic Infections and Treatments
- SARS-CoV-2 detection and testing
- Infant Nutrition and Health
- Bee Products Chemical Analysis
- Fungal Biology and Applications
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- Immune responses and vaccinations
- Food Chemistry and Fat Analysis
Universidad San Francisco de Quito
2021-2024
Universidad de Las Américas
2020-2021
Universidade de São Paulo
2018
Universidade Cidade de São Paulo
2018
Universidad Técnica de Ambato
2018
Washington University in St. Louis
2015-2018
Universidad Nacional Autónoma de México
2005-2016
Instituto Nacional de Cardiología
2012
Natural compounds have diverse structures and are present in different forms of life. Metabolites such as tannins, anthocyanins, alkaloids, among others, serve a defense mechanism live organisms undoubtedly interest for the food, cosmetic pharmaceutical industries. Plants, bacteria, insects represent source biomolecules with activities, poorly studied many cases. To use these molecules applications, it is essential to know their structure, concentrations, biological activity potential. In...
Abstract Schiff bases are organic compounds recognized for their biological activities, including antiviral, antibacterial, antifungal, and anticancer properties, making them promising candidates in medicinal chemistry. In this studio, a series of 3a – h derived from 4-aminoantipyrine substituted cinnamaldehydes were evaluated vitro against liver (HepG2) thyroid (THJ29T) cancer cells, Gram-positive Gram-negative multidrug-resistant bacteria, biofilm-forming pathogens. Six demonstrated...
This study evaluates the comprehensive biological activities of anthocyanins isolated from Andean blueberry (Vaccinium floribundum Kunth) and blackberry (Rubus glaucus Benth), focusing on their antimicrobial, antioxidant, antitumoral, anti-inflammatory, hemolytic properties. Chemical characterization revealed significant anthocyanin content with complex mass spectrometric profiles indicating diverse glycosylation patterns, which might influence bioactivity. The antimicrobial assays...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
CRISPR/Cas9 has emerged as the predominant method for genome editing due to its cost-effectiveness and broad applicability, playing a crucial role in advancing sustainable practices across various sectors. This systematic review leverages PRISMA methodology explore CRISPR/Cas9's impact on environmental protection, thereby supporting Sustainable Development Goals (SDGs). Analyzing data from Web of Science, found significant growth related publications, with 30% increase since 2014,...
Abstract The oxygenic photosynthetic bacterium Synechocystis sp. PCC 6803 (S6803) is a model cyanobacterium widely used for fundamental research and biotechnology applications. Due to its polyploidy, existing methods genome engineering of S6803 require multiple rounds selection modify all copies, which time‐consuming inefficient. In this study, we engineered the Cas9 tool one‐step, segregation‐free engineering. We further our delete three seven native plasmids. Our results show that...
Despite its ability to grow and produce high-value molecules using renewable carbon sources, two main factors must be improved use Burkholderia sacchari as a chassis for bioproduction at an industrial scale: first, the lack of molecular tools engineer this organism second, inherently slow growth rate poly-3-hydroxybutyrate [P(3HB)] production xylose. In work, we have addressed both factors.First, adapted set BglBrick plasmids showed tunable expression in B. sacchari. Finally, assessed P(3HB)...
Pollen, a remarkably versatile natural compound collected by bees for its abundant source of proteins and nutrients, represents rich reservoir diverse bioactive compounds with noteworthy chemical therapeutic potential. Its large range biological effects has been known exploited since ancient times. Today, there is an increased interest in finding agaisnt oxidative stress, factor that contributes to various diseases. Recent research unraveled multitude activities associated bee pollen,...