A5076771459- Forensic and Genetic Research
- Carcinogens and Genotoxicity Assessment
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Genetic diversity and population structure
- RNA and protein synthesis mechanisms
- Race, Genetics, and Society
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Genetic Neurodegenerative Diseases
- DNA Repair Mechanisms
- Biotechnology and Related Fields
- Pesticide Exposure and Toxicity
- Nuclear Receptors and Signaling
- SARS-CoV-2 and COVID-19 Research
- Genomics and Rare Diseases
- COVID-19 Clinical Research Studies
- Machine Learning in Bioinformatics
- Genetic Associations and Epidemiology
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Hereditary Neurological Disorders
Universidad UTE
2017-2024
National Archives of Ecuador
2022
University of Chile
2020
Universidad de Las Américas
2010-2018
Central University of Ecuador
1990-2017
Universidad de las Américas
2017
Artistic Realization Technologies
2014
Pontificia Universidad Católica del Ecuador
1997-2009
Universidad de las Américas Puebla
2009
Hospital Universitario Fundación Jiménez Díaz
1990
Abstract Over the past decades, consistent studies have shown that race/ethnicity a great impact on cancer incidence, survival, drug response, molecular pathways and epigenetics. Despite influence of in outcomes its health care quality, comprehensive understanding racial/ethnic inclusion oncological research has never been addressed. We therefore explored composition samples/individuals included fundamental (patient-derived models, biobanks genomics) applied (clinical trials). Regarding...
The Americas were the last inhabitable continents to be occupied by humans, with a growing multidisciplinary consensus for entry 15-25 thousand years ago (kya) from northeast Asia via former Beringia land bridge [1-4]. Autosomal DNA analyses have dated separation of Native American ancestors Asian gene pool 23 kya or later [5, 6] and mtDNA ∼25 [7], followed isolation ("Beringian Standstill" [8, 9]) 2.4-9 ky then rapid expansion throughout Americas. Here, we present calibrated sequence-based...
We analyzed the incidence of structural and numerical chromosomal aberrations (CAs) in workers a plantation flowers located Quito, Ecuador, South America. This study included 41 individuals occupationally exposed to 27 pesticides, some which are restricted many countries classified as extremely toxic by World Health Organization; among these aldicarb fenamiphos. The same number age, sex, geographic area were selected controls. Workers pesticides showed an increased frequency CA compared with...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with highest incidence worldwide. HNSCC often diagnosed at advanced stages, incurring significant high mortality morbidity. The use of saliva, as a noninvasive tool for diagnosis cancer, has recently increased. Salivary microRNAs (miRNAs) have emerged promising molecular early HNSCC. aim was to identify differential expression salivary miRNAs associated in altitude mestizo Ecuadorian population. Using PCR Arrays,...
Abstract Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein expression deregulation, signaling pathway hormone disruption, ethnicity and environmental determinants are involved. Due to the complexity of BC, prediction proteins involved in this trending topic drug design. This work proposing accurate classifier for BC using six sets sequence descriptors 13 machine-learning methods. After univariate feature selection mix five descriptor families, best was obtained...
Abstract The history of Ecuador was marked by the arrival Europeans with Africans, resulting in mixture Native Americans Africans and Europeans. present study contributes to knowledge Ecuadorian mestizo population offering information about ancestry ethnic heterogeneity. Forty-six AIM-InDels (Ancestry Informative Insertion/Deletion Markers) were used obtain on 240 individuals from three regions (Amazonia, Highlands, Coast). As a result, involved significant contribution (values up 51%),...
Breast cancer (BC) is the leading cause of cancer-related death among women and most commonly diagnosed worldwide. Although in recent years large-scale efforts have focused on identifying new therapeutic targets, a better understanding BC molecular processes required. Here we elucidating hallmarks heterogeneity oncogenic mutations involved precision medicine that remains poorly defined. To fill this gap, established an OncoOmics strategy consists analyzing genomic alterations, signaling...
We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in northern part Ecuador. A total 24 exposed and 21 unexposed control individuals were investigated using comet assay. The results showed higher degree DNA damage group (comet length = 35.5 µm) compared 25.94 µm). These suggest that formulation used during had genotoxic effect on individuals.
Understanding the forces that shaped Neotropical diversity is central issue to explain tropical biodiversity and inform conservation action; yet few studies have examined large, widespread species. Lowland tapir (Tapirus terrrestris, Perissodactyla, Tapiridae) largest herbivore whose ancestors arrived in South America during Great American Biotic Interchange. A Pleistocene diversification inferred for genus Tapirus from fossil record, but only two species survived megafauna extinction. Here,...
Abstract Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, main objective this study apply theoretical approaches explore genes and communities directly involved breast cancer (BC) pathogenesis. We evaluated consensus between 8 prioritization strategies for early pathogenic genes. A communality analysis protein-protein interaction (PPi) network previously selected enriched with gene ontology, metabolic pathways, as well...
The human Y chromosome contains highly informative markers for making historical inferences about the pre-Columbian peopling of Americas. However, scarcity these has limited its use in inference shared ancestry and past migrations relevant to origin culturally biologically diverse Native Americans. To identify new single nucleotide polymorphisms (SNPs) increase phylogenetic resolution major haplogroup Q found Americas, we have performed a search based on sequencing divergent chromosomes...
The systemic information enclosed in microarray data encodes relevant clues to overcome the poorly understood combination of genetic and environmental factors Parkinson's disease (PD), which represents major obstacle understand its pathogenesis develop disease-modifying therapeutics. While several gene prioritization approaches have been proposed, none dominate over rest. Instead, hybrid seem outperform individual approaches. A consensus strategy is proposed for PD related from mRNA based on...
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014. Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR (MTRR) are enzymes that play an important role folate metabolism. The single nucleotide polymorphisms, MTHFR C677T, A1298C, A2756G, MTRR A66G, alter plasmatic homocysteine concentrations, causing problems during repairment, synthesis, methylation genetic material. Therefore, it essential to know how BC risk associated with...
Summary This study focuses on the genetic history of Quechua‐Lamistas, inhabitants Lamas Province in San Martin Department, Peru, who speak their own distinct variety Quechua family languages. It has been suggested that different pre‐Columbian ethnic groups from Peruvian Amazonia, like Motilones or “shaven heads”, assimilated language and then formed current native population Lamas. However, many Quechua‐Lamistas claim to be direct descendants Chankas, a famous indigenous group escaped Inca...
Breast cancer is the leading cause of cancer-related death among women worldwide. AKT1 encodes kinase B alpha protein. The rs121434592, rs12881616, rs11555432, rs11555431, rs2494732, and rs3803304 single nucleotide polymorphisms have been identified in gene. Activated phosphorylates downstream substrates regulating cell growth, metabolism, apoptosis, angiogenesis, drug responses. It essential to know how breast risk associated with histopathological immunohistochemical characteristics...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
Bladder cancer represents 8% of all malignancies diagnosed in men and 3% women. The risk factors for developing bladder cancer, including the incidence rate, morbidity, mortality, vary according to ethnic group, exposition rate at work, age, gender, tobacco consumption. Moreover, there is a this carcinoma due dietary conditions, demonstrating that certain enzymes neutralize oxidative compound derivative carcinogens, which if not degraded, accumulate body destroy epithelial cells bladder,...