A5027262300- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- DNA Repair Mechanisms
- Pregnancy and preeclampsia studies
- Forensic and Genetic Research
- Global Maternal and Child Health
- Chronic Myeloid Leukemia Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Environmental Toxicology and Ecotoxicology
- Molecular Biology Techniques and Applications
- Genetically Modified Organisms Research
- Telomeres, Telomerase, and Senescence
- Demographic Trends and Gender Preferences
- Genetic diversity and population structure
- Health, Environment, Cognitive Aging
- Pesticide and Herbicide Environmental Studies
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Smoking Behavior and Cessation
- Radiation Effects and Dosimetry
- Acute Myeloid Leukemia Research
- Globalization and Cultural Identity
- Glutathione Transferases and Polymorphisms
Instituto Cajal
2024
Instituto Ramón y Cajal de Investigación Sanitaria
2024
Central University of Ecuador
2007-2024
Universidad de Las Américas
2007-2021
Hospital San Pedro
2012
Pontificia Universidad Católica del Ecuador
1995-2008
University of Puerto Rico System
2005
New Mexico Highlands University
1999
We analyzed the incidence of structural and numerical chromosomal aberrations (CAs) in workers a plantation flowers located Quito, Ecuador, South America. This study included 41 individuals occupationally exposed to 27 pesticides, some which are restricted many countries classified as extremely toxic by World Health Organization; among these aldicarb fenamiphos. The same number age, sex, geographic area were selected controls. Workers pesticides showed an increased frequency CA compared with...
We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in northern part Ecuador. A total 24 exposed and 21 unexposed control individuals were investigated using comet assay. The results showed higher degree DNA damage group (comet length = 35.5 µm) compared 25.94 µm). These suggest that formulation used during had genotoxic effect on individuals.
Breast cancer (BC) is the leading cause of cancer-related death among women in 2014. Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and MTR (MTRR) are enzymes that play an important role folate metabolism. The single nucleotide polymorphisms, MTHFR C677T, A1298C, A2756G, MTRR A66G, alter plasmatic homocysteine concentrations, causing problems during repairment, synthesis, methylation genetic material. Therefore, it essential to know how BC risk associated with...
Bladder cancer represents 8% of all malignancies diagnosed in men and 3% women. The risk factors for developing bladder cancer, including the incidence rate, morbidity, mortality, vary according to ethnic group, exposition rate at work, age, gender, tobacco consumption. Moreover, there is a this carcinoma due dietary conditions, demonstrating that certain enzymes neutralize oxidative compound derivative carcinogens, which if not degraded, accumulate body destroy epithelial cells bladder,...
Currently, it is known that several chemical agents used or generated by the oil industry are classified as mutagens and/or carcinogens. Among these we have gasoline, diesel, butane gas, styrene, benzene, chloroform, and others. Studies verified chemicals effects in fertility (abortions, sterility); produce various upheavals, such dizziness, nausea, muscular pain; chromosomal damage at DNA level, which long medium run, can develop into cancer leukemia. The genetic exposed individuals was...
Abstract Background In Ecuador eclampsia and preeclampsia were identified as the third cause of maternal death. Like other Latin-American countries, has human settlements living from 0 to more than 4000 m altitude comprising a wide ethnic-diversity across all these changes. These characteristics offer possibility study variety possible risk factors for eclampsia. Methods We conducted population-based retrospective deliveries in 2015 through 2017. The main variables analyzed were: altitude,...
Anisakidosis, human infection with nematodes of the family Anisakidae, is caused most commonly by Anisakis simplex. Acquired consumption raw or undercooked marine fish squid, anisakidosis occurs where such dietary customs are practiced, including Japan, coastal regions Europe and United States. Rupture spleen a relatively common complication trauma many systemic disorders affecting reticuloendothelial system, infections neoplasias. A rare subtype rupture occurring spontaneously arising from...
Abstract The Spanish Familial Pancreatic Cancer Registry (PANGENFAM) was established in 2009 and aims to characterize the genotype phenotype of familial pancreatic cancer (FPC). Furthermore, an early detection screening program for ductal adenocarcinoma (PDAC) is provided healthy high-risk individuals from FPC hereditary families (first-degree relatives). This article describes our experience over last 10 years screening. Hereditary were identified through oncology gastroenterology units....
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in Western world. The number diagnosed cases and mortality rate are almost equal as majority patients present with advanced disease at diagnosis. Between 4 10% pancreatic cancer have an apparent hereditary background, known (HPC) familial (FPC), when genetic basis unknown. Surveillance high-risk individuals (HRI) from these families by imaging aims to detect PDAC early stage improve...
Preeclampsia is a hypertensive disorder that occurs during pregnancy. It complex disease with unknown pathogenesis and the leading cause of fetal maternal mortality Using all drugs currently under clinical trial for preeclampsia, we extracted their possible targets from DrugBank ChEMBL databases labeled them as "targets". The proteins "off-targets" were in same way but while taking antihypertensive which are inhibitors ACE and/or angiotensin receptor antagonist query molecules....
The hRAD54 gene is a key member of the RAD52 epistasis group involved in repair double-strand breaks (DSB) by homologous recombination (HR). Thus, alterations normal function these genes could generate genetic instability, shifting process cell cycle, leading cells to develop into cancer. In this work we analyzed exon 18 gene, which has been previously reported our carry silent polymorphism, 2290 C/T (Ala730Ala), associated meningiomas. We performed PCR-SSCP method detect polymorphism 239...
Medical genetics is a field marked by fast progress. Even though it was at one point confined to group of relatively rare diseases, today has become central component in the understanding disorders and subject interest for all medical specialties. This paper, shares data on chromosomal alterations variations that have been diagnosed Ecuadorian patients since 1998. A total 2,636 individual cases analyzed G-banding technique until February 2012. The present work shows this collection important...
Genotoxicity studies in Ecuador have been carried out during the past two decades. The focuses of research were mainly area environmental issues, where populations accidentally exposed to contaminants and occupational exposure individuals at workplace. This paper includes population Amazon region, a zone known for its rich biodiversity as well ecological damage caused by oil spills chemical sprayings whose consequences continue be controversial. Additionally, we show results comprised...