A5103132513- Folate and B Vitamins Research
- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Trace Elements in Health
- Mitochondrial Function and Pathology
- Ginkgo biloba and Cashew Applications
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Glutathione Transferases and Polymorphisms
- Blood disorders and treatments
- Corporate Governance and Management
- Garlic and Onion Studies
- Drug Solubulity and Delivery Systems
- Opioid Use Disorder Treatment
- Wnt/β-catenin signaling in development and cancer
- Child Abuse and Related Trauma
- GDF15 and Related Biomarkers
- Coenzyme Q10 studies and effects
- EEG and Brain-Computer Interfaces
- Alcoholism and Thiamine Deficiency
- Fluoride Effects and Removal
- Sustainable Supply Chain Management
Secretaría de Salud de Bogotá
2023
Universidad de La Sabana
2023
Universidad del Norte
2022
Baylor College of Medicine
2022
Duke University Hospital
2020
University of Massachusetts Lowell
2001-2010
Cornell University
2008
New Mexico Highlands University
1999
Abstract Homocysteine (HC) is a neurotoxic amino acid that accumulates in several neurological disorders including Alzheimer's disease (AD). We examined the consequences of treatment cultured murine cortical neurons with HC. Homocysteine‐induced increases cytosolic calcium, reactive oxygen species, phospho‐tau immunoreactivity and externalized phosphatidyl serine (indicative apoptosis). calcium influx through NMDA channel activation, which stimulated glutamate excitotoxicity, as evidenced by...
Summary Objective To assess vitamin D status and the influences of race, sun exposure dietary intake on levels, to evaluate two repletion regimens in extremely obese patients awaiting bariatric surgery. Methods A cross‐sectional analysis D, exposure, PTH [intact (iPTH) PTH(1‐84)] 25‐hydroxyvitamin (25OHD; differentiated 25OHD2 25OHD3) 56 [body mass index (BMI) > 35 kg/m 2 ] men women (age 20–64 years). In a pilot clinical trial, 27 subjects with 25OHD levels < 62 nmol/l were randomized...
This paper reports on the preparation of a water-soluble nanoemulsion highly lipid-soluble drug tamoxifen (TAM). In addition, relative to suspension TAM, demonstrated greater zeta potential (increased negative charge) which has previously been associated with increasing drug/membrane permeability. study also that suspensions TAM particle sizes than 6000 nm, nanoemulsions having mean 47 inhibited cell proliferation 20-fold and increased apoptosis 4-fold in HTB-20 breast cancer line. Thus,...
Cyclin-dependent kinase 5 (cdk5) phosphorylates the high molecular weight neurofilament (NF) protein. Overexpression of cdk5 inhibits NF axonal transport and induces perikaryal accumulation disordered phospho-NF cables. Experimental clinical motor neuron disease is characterized by oxidative stress, increased activity, phospho-NFs within perikarya or proximal axons. Because stress increases activity in experimental disease, we examined whether induced cdk5-mediated phosphorylation. Treatment...
Oxidative stress is an early neurodegenerative insult in Alzheimer's disease (AD). Antioxidant mechanisms, including elements of the glutathione (GSH) pathway, undergo at least a transient compensatory increase that apparently insufficient due to
Oxidative stress is an early hallmark of affected neurons in Alzheimer's disease (AD). The antioxidant vitamin E provided limited neuroprotection AD, which may have derived from its lipophilic nature and resultant inability to quench cytosolic rea
Exposure of cultured neurons and neuronal cells to aggregated amyloid-β (Aβ) induces multiple neurodegenerative events including accumulation cytosolic calcium, generation reactive oxygen species, abnormal levels phosphorylation the microtubule-associated protein tau, apoptosis. Prevention calcium within cytosol also prevents all other events, suggesting that is an early pivotal event in Aβ neurotoxicity. Calcium influx has been suggested occur via L voltage-sensitive channels or NMDA...
Abstract Oxidative stress is a major contributing factor in neurodegeneration and can arise from dietary, environmental, genetic sources. Here we examine the separate combined impact of deprivation folate vitamin E, coupled with dietary iron as prooxidant, on normal mice transgenic lacking apolipoprotein E (ApoE–/– mice). Both mouse strains exhibited increased levels glutathione when deprived but substantial further increase was observed ApoE–/– mice. To determine mechanism(s) underlying...
Oxidative stress contributes to age-related cognitive decline. In some instances, consumption of fruits and vegetables rich in antioxidant can provide superior protection than supplementation with purified antioxidants. Our prior studies have shown t
Increased oxidative stress contributes to the decline in cognitive performance during normal aging and neurodegerative conditions such as Alzheimer's disease. Dietary supplementation with fruits vegetables that are high antioxidant potentia
The E4 allele of apolipoprotein E (ApoE) is associated with neurodegeneration in part due to increased oxidative stress. Transgenic mice lacking ApoE (-/-) represent a model for the consequences deficiencies function. Dietary deficiency folate and vitamin has previously been shown t o potentiate impact deficiency; ApoE-/- deprived 1 month demonstrated damage brain tissue impaired cognitive performance as compared ApoE+/+ mice. Since individuals homozygous can demonstrate more risk an earlier...
Increased homocysteine has in some cases been linked with an increased incidence of Alzheimer's disease and motor neuron disease. Folate or B12 deficiency increases homocysteine, but controversy exists as to whether their levels also correlate e