A5082878069- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Forensic and Genetic Research
- COVID-19 Clinical Research Studies
- Hereditary Neurological Disorders
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Race, Genetics, and Society
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Telomeres, Telomerase, and Senescence
- SARS-CoV-2 and COVID-19 Research
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
- Genetic diversity and population structure
- Artificial Intelligence in Healthcare and Education
- BRCA gene mutations in cancer
- Biotechnology and Related Fields
- Digestive system and related health
- Genetics, Aging, and Longevity in Model Organisms
- Pharmacogenetics and Drug Metabolism
Universidad Internacional del Ecuador
2021-2025
Universidade da Coruña
2022
Universidad UTE
2017-2021
Universidad de Las Américas
2016
University of Nottingham
2015
Johnson Space Center
1995
Abstract Over the past decades, consistent studies have shown that race/ethnicity a great impact on cancer incidence, survival, drug response, molecular pathways and epigenetics. Despite influence of in outcomes its health care quality, comprehensive understanding racial/ethnic inclusion oncological research has never been addressed. We therefore explored composition samples/individuals included fundamental (patient-derived models, biobanks genomics) applied (clinical trials). Regarding...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with highest incidence worldwide. HNSCC often diagnosed at advanced stages, incurring significant high mortality morbidity. The use of saliva, as a noninvasive tool for diagnosis cancer, has recently increased. Salivary microRNAs (miRNAs) have emerged promising molecular early HNSCC. aim was to identify differential expression salivary miRNAs associated in altitude mestizo Ecuadorian population. Using PCR Arrays,...
Abstract The history of Ecuador was marked by the arrival Europeans with Africans, resulting in mixture Native Americans Africans and Europeans. present study contributes to knowledge Ecuadorian mestizo population offering information about ancestry ethnic heterogeneity. Forty-six AIM-InDels (Ancestry Informative Insertion/Deletion Markers) were used obtain on 240 individuals from three regions (Amazonia, Highlands, Coast). As a result, involved significant contribution (values up 51%),...
Alternative Lengthening of Telomeres (ALT) is a telomerase-independent mechanism deployed by several aggressive cancers to maintain telomere length. This contributes their malignancy and resistance conventional therapies. In prior studies, we have identified key proteins linked the ALT process using multi-omic data integration strategies. this work, combined metabolomic datasets with our earlier results identify targetable metabolic pathways for ALT-positive tumors. 39 ALT-related were found...
Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field chronobiology has increased our understanding how rhythm disturbances contribute to cancer pathogenesis, circadian timing influences the efficacy treatments. As clock steadily gains recognition as an emerging factor in...
Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing human tissues, artificial neural networks reveal potential for drug repurposing against COVID-19. Results: screened 1,584 high-confidence proteins ACE2 TMPRSS2 co-expressing cells, finding 25 significantly overexpressed nasal goblet secretory lung...
PURPOSE Ethnic diversity in cancer research is crucial as race/ethnicity influences incidence, survival, drug response, molecular pathways, and epigenetic phenomena. In 2018, we began a project to examine racial/ethnic research, with commitment review these disparities every 4 years. This report our second assessment, detailing the present state of genomics clinical trials. METHODS To study inclusion genomics, extracted ethnic records from all data sets available at cBioPortal (n = 125,128...
Scientific data recording and reporting systems are of a great interest for endorsing reproducibility transparency practices among the scientific community. Current research generates large datasets that can no longer be documented using paper lab notebooks (PLNs). In this regard, electronic laboratory (ELNs) could promising solution to replace PLNs promote transparency. We previously analyzed five ELNs performed two survey-based studies implement an ELN in biomedical institute. Among...
Breast cancer (BC) is the leading cause of cancer-associated death among women worldwide. Despite treatment efforts, advanced BC with distant organ metastases considered incurable. A better understanding molecular processes therefore great interest to identify new therapeutic targets. Although large-scale such as The Cancer Genome Atlas (TCGA), have completely redefined drug development, diagnosis, and treatment, additional key aspects tumor biology remain be discovered. In that respect,...
Prostate cancer (PC) is the most frequently diagnosed in Ecuador (15.6%). The androgen receptor gene codes for a protein that has an androgen‑binding domain, DNA‑binding domain and N‑terminal which contains two polymorphic trinucleotide repeats (CAG GGC). aim of present study was to determine whether variations number repetitions CAG GGC are associated with pathological features risk developing PC. repeat lengths 108 mestizo patients PC, 148 healthy individuals, 78 indigenous individuals...
Many primary-tumor subregions exhibit low levels of molecular oxygen and restricted access to nutrients due poor vascularization in the tissue, phenomenon known as hypoxia. Hypoxic tumors are able regulate expression certain genes signaling molecules microenvironment that shift it towards a more aggressive phenotype. The transcriptional landscape tumor favors malignant transformation neighboring cells their migration distant sites. Herein, we focused on identifying key proteins participate...
Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third frequently encountered malignancy worldwide. Despite efforts in molecular subtyping subsequent personalized COREAD treatments, multidisciplinary evidence suggests separating into colon (COAD) rectal (READ). This new perspective could improve diagnosis treatment of both carcinomas. RNA-binding proteins (RBPs), as critical regulators every hallmark cancer, fulfill need to identify sensitive biomarkers for COAD READ...
Abstract Background Congenital insensitivity to pain with anhidrosis (CIPA) is an extremely rare autosomal recessive disorder characterized by pain, inability sweat and intellectual disability. CIPA caused mutations in the neurotrophic tyrosine kinase receptor type 1 gene ( NTRK1 ) that encodes high-affinity of nerve growth factor (NGF). Case presentation Here, we present clinical molecular findings a 9-year-old girl CIPA. The high-altitude indigenous Ecuadorian patient presented several...
Alternative lengthening of telomeres-associated promyelocytic leukemia nuclear bodies (APBs) are a hallmark telomere maintenance. In the last few years, APBs have been described as main place where telomeric extension occurs in ALT-positive cancer cell lines. A different set proteins associated with function, however, molecular mechanisms behind their assembly, colocalization, and clustering telomeres, among others, remain unclear. To improve understanding ALT pathway, we integrated...
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure the main cause death in COVID-19 patients, and host inflammatory response at lungs remains poorly understood. Methods: Therefore, we retrieved data from post-mortem patients performed in-depth silico analyses single-nucleus RNA sequencing data, protein interactome network, shortest pathways physiological phenotypes reveal potential therapeutic targets advanced-stage clinical...
Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85–90% reactivate telomerase, while 10–15% use the alternative lengthening of telomeres (ALT). Due anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism ALT; in fact, co-existence between both has been observed cancers. Although different elements ALT pathway uncovered, molecular still poorly understood. Therefore, with aim identify potential markers for study ALT, we...
More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions the cell should be investigated, such as post-transcriptional regulation. RNA-binding proteins (RBPs) emerging critical modulators tumorigenesis, but only few clear roles in BC. To recognize putative proteins, we performed integrated silico analyses all human RBPs (n = 1392) three...