A5027026478- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
University of Buenos Aires
2024
Universidad de Las Américas
2024
Fundación Ciencias Exactas y Naturales
2024
Universidad Internacional del Ecuador
2022
Universidad UTE
2020
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role development and progression of cancer significantly influencing activity cellular function. This insight has led to novel class therapeutic agents, known as epigenetic drugs. These drugs, including histone deacetylase inhibitors, acetyltransferase methyltransferase aim modulate curb growth uniquely landscape cells. Ongoing research clinical trials are rigorously...
Abstract Context The pituitary gland is key for childhood growth, puberty, and metabolism. Pituitary dysfunction associated with a spectrum of phenotypes, from mild to severe. Congenital hypopituitarism (CH) the most commonly reported pediatric endocrine dysfunction, an incidence 1:4000, yet low rates genetic diagnosis have been reported. Objective We aimed unveil etiology CH in large cohort patients Argentina. Methods performed whole exome sequencing 137 unrelated cases CH, largest examined...
Breast cancer (BC) is the leading cause of cancer-associated death among women worldwide. Despite treatment efforts, advanced BC with distant organ metastases considered incurable. A better understanding molecular processes therefore great interest to identify new therapeutic targets. Although large-scale such as The Cancer Genome Atlas (TCGA), have completely redefined drug development, diagnosis, and treatment, additional key aspects tumor biology remain be discovered. In that respect,...
More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions the cell should be investigated, such as post-transcriptional regulation. RNA-binding proteins (RBPs) emerging critical modulators tumorigenesis, but only few clear roles in BC. To recognize putative proteins, we performed integrated silico analyses all human RBPs (n = 1392) three...