A5024409549- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- RNA regulation and disease
- Lymphatic System and Diseases
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- melanin and skin pigmentation
- Protein Degradation and Inhibitors
- Telomeres, Telomerase, and Senescence
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
- Bacterial Genetics and Biotechnology
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Nuclear Structure and Function
- MicroRNA in disease regulation
- CAR-T cell therapy research
Spanish National Cancer Research Centre
2016-2025
Centro de Investigación del Cáncer
2009-2022
ORCID
2021
Universidad Autónoma de Madrid
1992-2016
Molecular Oncology (United States)
2016
Instituto de Salud Carlos III
2009
University Dermatology
2009
University of Michigan
2003-2008
Michigan Center for Translational Pathology
2006-2008
Advanced Dermatology
2007
Minna Woo, Razqallah Hakem, Maria S. Soengas, Gordon Duncan, Arda Shahinian, David Kägi, Anne Mila McCurrach, Wilson Khoo, Stephen A. Kaufman, Giorgio Senaldi, Tamara Howard, Scott W. Lowe, and Tak Mak Amgen Institute Ontario Cancer Institute, Department of Medical Biophysics Immunology, University Toronto, M5G2C1, Canada; Cold Spring Harbor Laboratory, Harbor, New York 11724 USA; Amgen, Inc., Thousand Oaks, CA 91320-1789 USA
The ability of p53 to promote apoptosis in response mitogenic oncogenes appears be critical for its tumor suppressor function. Caspase-9 and cofactor Apaf-1 were found essential downstream components Myc-induced apoptosis. Like null cells, mouse embryo fibroblast cells deficient caspase-9, expressing c- Myc , resistant apoptotic stimuli that mimic conditions developing tumors. Inactivation or caspase-9 substituted loss promoting the oncogenic transformation -expressing cells. These results...
Skin, the largest organ of human body, is organized into an elaborate layered structure consisting mainly outermost epidermis and underlying dermis. A subcutaneous adipose-storing hypodermis layer various appendages such as hair follicles, sweat glands, sebaceous nerves, lymphatics, blood vessels are also present in skin. These multiple components skin ensure survival by carrying out critical functions protection, thermoregulation, excretion, absorption, metabolic functions, sensation,...
In this report, we investigated BRAF/NRAS mutations in samples from a case–control study of melanoma and series benign melanocytic nevi. We evaluated potential associations between BRAF histopathologic pigmentary characteristics melanoma. Mutations NRAS were detected by sequencing microdissected/laser-captured DNA 18 in-situ melanomas, 64 primary 51 Nevi showed the highest frequency (82%). identified 29% invasive melanomas only 5.6% melanomas. found 5.2% 5.9% nevi no seen A majority observed...
Abstract Unlike other tumors, melanomas harbor wild-type (WT) p53 but exhibit impaired p53-dependent apoptosis. The mechanisms for the activation are poorly understood may be linked to high expression of suppressor Mdm2, which is found in >50% melanoma lesions. Here, we describe an organometallic glycogen synthase kinase 3β (GSK3β) inhibitor (DW1/2) as a potent activator and inducer cell death otherwise highly chemoresistant cells. Using RNA interference pharmacologic approaches, show...
Abstract Melanoma is the most aggressive form of skin cancer and advanced stages are invariably resistant to conventional therapeutic agents. Using bortezomib as a prototypic proteasome inhibitor, we have identified novel critical role in maintenance malignant phenotype melanoma cells that could direct translational implications. Thus, from early, intermediate, late disease not sustain inhibition underwent an effective activation caspase-dependent -independent death programs. This effect was...
The proteasome controls a plethora of survival factors in all mammalian cells analyzed to date. Therefore, it is puzzling that inhibitors such as bortezomib can display preferential toxicity toward malignant cells. In fact, have the salient feature promoting dramatic induction proapoptotic protein NOXA tumor cell-restricted manner. However, molecular determinants control this specific regulation are unknown. Here, we show by directly dependent on oncogene c-MYC. This requirement for c-MYC...
Abstract Gain of chromosome 6p is a consistent feature advanced melanomas. However, the identity putative oncogene(s) associated with this amplification has remained elusive. The chromatin remodeling factor DEK an attractive candidate as it maps to (within common melanoma-amplified loci). Moreover, expression increased in metastatic melanomas, although functional relevance induction remains unclear. Importantly, other tumor types, can display various tumorigenic effects part through its...
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state melanoma research and care. Intensive discussions among members MRF Scientific Advisory Council Breakthrough Consortium, group that included clinicians scientists, focused on four thematic areas - diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), therapy (response resistance). These extended over course 2015 culminated at Society International Congress in...
Five years ago, the Melanoma Research Foundation (MRF) conducted an assessment of challenges and opportunities facing melanoma research community patients with melanoma. Since then, remarkable progress has been made on both basic clinical fronts. However, incidence, recurrence, death rates for remain unacceptably high significant remain. Hence, MRF Scientific Advisory Council Breakthrough Consortium, a group that includes clinicians scientists, reconvened to facilitate intensive discussions...