A5017093089- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac electrophysiology and arrhythmias
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Foot and Ankle Surgery
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Effects of Exercise
- Obesity, Physical Activity, Diet
- Pharmacological Effects and Toxicity Studies
- Clinical Laboratory Practices and Quality Control
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Cardiovascular Function and Risk Factors
- Antibiotics Pharmacokinetics and Efficacy
- Reproductive Health and Contraception
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- NF-κB Signaling Pathways
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
Australian National University
2013-2025
Canberra Hospital
2012-2025
University of Chichester
2012-2023
Act Health
2023
Royal Brisbane and Women's Hospital
2022
ACT Government
2007-2020
South Australia Pathology
2004-2018
University of Southampton
2000-2016
Boston Medical Center
2015-2016
Boston University
2015
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription expressed only in lymphocytes. Mice deficient IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited profound reduction serum immunoglobulin concentrations did not mount detectable antibody responses. lymphocyte function was also impaired vivo; these could generate cytotoxic or antitumor Thus,...
Phosphorylation of IκB, an inhibitor NF-κB , is important step in the activation transcription factor . mediated by IκB kinase (IKK) complex, known to contain two catalytic subunits: IKKα and IKKβ A novel, noncatalytic component this complex called NEMO ( N F-κB e ssential mo dulator)/ IKKγ was identified recently. We have generated NEMO/IKKγ -deficient mice gene targeting. Mutant embryos die at E12.5–E13.0 from severe liver damage due apoptosis. primary murine embryonic fibroblasts (MEFs)...
Background In a previous longitudinal analysis of our cohort as 8 to 10 year-olds, insulin resistance (IR) increased with age, but was not modified by changes in percent body fat (%BF), and only responsive physical activity (PA) boys. We aimed determine whether these responses persisted the children approached adolescence. Methods this prospective study, 256 boys 278 girls were assessed at ages 8, 12 years for fasting blood glucose insulin, %BF (dual energy X-ray absorptiometry); PA (7-day...
To explore the experience of reproductive-age women in French population with premenstrual syndrome (PMS) by estimating perceived symptom prevalence, identifying risk factors, and quantifying burden symptoms. This study also assesses stability PMS diagnosis over a 1-year period follow-up.The prevalence reported was estimated from population-based cohort 2863 interviewed 2003 2004. Multivariate logistic regressions were used to identify factors associated PMS. fluctuation studied comparing...
Abbott Diagnostics have developed a new highly sensitive troponin I (hs-TnI) assay. We assessed its analytical characteristics and applied the assay to population of apparently cardio-healthy persons.We imprecision, bias compared previous generation assay, matrix effects, interferences an healthy population, deriving 99th percentile limit distribution values in reference populations for men women separately.The dynamic range was ranged from 0.5-50,000 ng/L (pg/mL). The 10% CV at...
OBJECTIVE--To estimate the prevalence of important side effects in patients with malignant disease who were receiving high doses morphine as part their palliative treatment. DESIGN--Data on collected over 12 months. SETTING--Two care units Western Australia. PATIENTS--19 Patients either subcutaneously or orally main analgesic. 10 a total daily dose at least 500 mg 250 parenterally enrolled study. The other 9 after an problem thought to be related had been identified. All taking drugs...
Abstract Using the technique of homologous recombination in embryonic stem cells, a mouse strain without functional CD4 and CD8 genes has been generated. Surprisingly, these mice contain significant numbers αβ T cells. Although deficient for only do not show any cytotoxic response when their cells are stimulated with either alloantigen or viral antigen, − 8 generate alloreactive These bear cell receptor recognize major histocompatibility complex class I antigens. In addition fully allogeneic...
Summary Adrenocortical function was tested in 12 patients following a single lumbar extradural injection ofmethyl‐prednisolone acetate (‘Depo‐Medrol’) 80 mg as treatment for chronic sciatica. There no absorption of the corticosteroid into systemic circulation, but marked suppression plasma Cortisol levels documented up to 3 weeks and capacity adrenal cortex secrete response synthetic adrenocorticotrophin (ACTH) diminished. These results suggest that dose frequency steroid administration...