A5004367373- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Travel-related health issues
- Climate Change and Health Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Cardiac Arrest and Resuscitation
- Adventure Sports and Sensation Seeking
- Traumatic Brain Injury and Neurovascular Disturbances
- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Winter Sports Injuries and Performance
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Injury Epidemiology and Prevention
- Hemoglobin structure and function
- Birth, Development, and Health
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Sleep and related disorders
- Anesthesia and Pain Management
- Global Education and Multiculturalism
University of Colorado Anschutz Medical Campus
2018-2025
University of Colorado Denver
2011-2022
Tyrone County Hospital
2021
United Services Automobile Association
2020
Lawrence Livermore National Security
2019-2020
Institute for Altitude Medicine
2009-2019
University of Colorado Boulder
2017
Telluride Adaptive Sports Program
2009-2016
University of Geneva
2011
Woodend Hospital
2006
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Bärtsch, Andrew M. Luks, Martin J. MacInnis, Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. 2018 Acute Mountain Sickness Score. High Alt Med Biol 19:1-4, 2018.- (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, not closely related AMS. To...
Context.—Because of its onset in generally remote environments, high-altitude cerebral edema (HACE) has received little scientific attention. Understanding the pathophysiology might have implications for prevention and treatment both this disorder much more common acute mountain sickness.Objectives.—To identify a clinical imaging correlate HACE determine whether is primarily vasogenic or cytotoxic.Design.—Case-comparison study.Setting.—Community hospitals accessed by helicopter from...
Pulmonary gas exchange was studied on members of the American Medical Research Expedition to Everest at altitudes 8,050 m (barometric pressure 284 Torr), 8,400 (267 Torr) and 8,848 (summit Mt. Everest, 253 Torr). Thirty-four valid alveolar samples were taken using a special automatic sampler including 4 summit. Venous blood collected from two subjects an altitude morning after their successful summit climb. Alveolar CO2 partial (PCO2) fell approximately linearly with decreasing barometric...
Maximal exercise at extreme altitudes was studied during the course of American Medical Research Expedition to Everest. Measurements were carried out sea level [inspired O2 partial pressure (PO2) 147 Torr], 6,300 m air breathing (inspired PO2 64 Torr), 16% 49 and 14% 43 Torr). The last is equivalent that on summit Mt. All studies in a warm well-equipped laboratory well-acclimatized subjects. uptake fell dramatically as inspired reduced very low levels. However, two subjects able reach an 1...
High-altitude pulmonary edema (HAPE), a severe form of altitude illness that can occur in young healthy individuals, is noncardiogenic associated with high concentrations proteins and cells bronchoalveolar lavage (BAL) fluid (Schoene et al., J. Am. Med. Assoc. 256: 63–69, 1986). We hypothesized acute mountain sickness (AMS) which gas exchange impaired to milder degree precursor HAPE. therefore performed BAL 0.89% NaCl by fiberoptic bronchoscopy eight subjects at 4,400 m (barometric pressure...
HIGH-ALTITUDE pulmonary edema is an unusual and puzzling illness.1,2 We have seen four patients without a right artery, all of whom had high-altitude at moderate altitudes (2000 to 3000 m) in Colorado. Both these conditions are so uncommon that their association by chance highly unlikely. The implications this were recognized Dr. Houston when the first our cases was called his attention another member group. In each developed left lung, which received entire ventricular output. This occurrence .
▪ Objective: To determine the efficacy of acetazolamide in treatment patients with acute mountain sickness and effect drug on pulmonary gas exchange sickness. Design: A randomized, double-blind, placebocontrolled trial. Setting: The Denali Medical Research Project highaltitude research station (4200 m) Mt. McKinley, Alaska. Participants: Twelve climbers attempting an ascent McKinley (summit, 6150 who presented to medical Intervention: Climbers were randomly assigned receive acetazolamide,...
To evaluate the cellular and biochemical composition of bronchoalveolar fluid in high-altitude pulmonary edema (HAPE), we performed lavage three climbers with HAPE a research facility at 4400 m on Mount McKinley. Three healthy were used as controls. The fluids contained marked increases high-molecular-weight proteins, erythrocytes, leukocytes, most which alveolar macrophages. also detectable amounts leukotriene B4 other lipoxygenase products arachidonic acid metabolism, complement fragments...
At very high altitude, exercise performance in the human sojourner may depend on a sufficient hypoxic ventilatory response (HVR). To study relationship of HVR to at we studied sea level and 5,400 m ventilation level, m, 6,300 nine members American Medical Research Expedition Everest. The between individuals was maintained when repeated after acclimatization (P less than 0.05). There significant correlation all subjects equivalent during (r = 0.704, P Subjects were then grouped into (H) low...
The presence of pulmonary, cerebral, and/or peripheral edema in acute mountain sickness (AMS) implies a derangement the body's handling water. Previously, we demonstrated water retention and increased symptoms AMS when hypocapnia was prevented subjects exposed to simulated high altitude. This led us hypothesis that upon ascent altitude, those persons who fail increase their ventilation adequately hence do not become hypocapnic will retain reflected as weight gain develop AMS. To test this...