A5078513895- High Altitude and Hypoxia
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Neuroscience of respiration and sleep
- Travel-related health issues
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Climate Change and Health Impacts
- Retinopathy of Prematurity Studies
- Adipose Tissue and Metabolism
- EEG and Brain-Computer Interfaces
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Circadian rhythm and melatonin
- Astrophysics and Star Formation Studies
- Retinal and Macular Surgery
- Anesthesia and Neurotoxicity Research
- Petri Nets in System Modeling
- Atmospheric Ozone and Climate
- Advanced Queuing Theory Analysis
STZ eyetrial
2010-2020
University of Tübingen
2010-2019
Klinikum Stuttgart
2015-2019
Katharinenhospital
2014-2019
Centre for Sight
2011-2013
Universitäts-Augenklinik Bonn
2013
TH Bingen University of Applied Sciences
2013
Heidelberg University
2013
University of Pennsylvania
2009-2012
University of Cologne
2009-2012
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Bärtsch, Andrew M. Luks, Martin J. MacInnis, Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. 2018 Acute Mountain Sickness Score. High Alt Med Biol 19:1-4, 2018.- (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, not closely related AMS. To...
To assess the safety of transcorneal electrical stimulation (TES) and explore its efficacy in various subjective objective parameters visual function patients with retinitis pigmentosa (RP).Twenty-four this prospective, randomized, partially blinded, good-clinical-practice study underwent TES (5-ms biphasic pulses; 20 Hz; DTL electrodes) 30 minutes per week for 6 consecutive weeks. The were randomly assigned to one three groups: sham, 66%, or 150% individual phosphene threshold (EPT). Visual...
Purpose: After promising results of an exploratory study, this study was designed to assess the safety and efficacy transcorneal electrical stimulation (TES) over 1 year in patients with retinitis pigmentosa (RP). Methods: We included 52 RP prospective, randomized, partially-masked which done accordance rules good clinical practice. Transcorneal by Okustim applied monocularly for 30 minutes per week consecutive weeks. Patients were assigned randomly groups: sham, 150%, or 200% individual...
The layered performance modeling approach is refined and extended to cover the latest CCITT Blue Book specifications. Specific submodels for higher-level functional blocks, such as message transfer part (MTP) level 3, signaling connection control (SCCP), ISDN user (ISDN-UP), transaction capabilities application (TCAP), are given in a generic way, explicitly. With these submodels, models points constructed. major parts of protocol architecture SS7 modeled way by queuing network elements full...
Transcorneal electrical stimulation (TES) has been beneficial in several neurodegenerative ocular diseases, but the exact mechanisms remain to be elucidated. This study was conducted investigate effects of TES on retinas wild-type Brown Norway (BN) rats by gene expression profiling and assess its retinal function morphology.TES applied BN rat vivo for 1 hour (1-ms biphasic pulses at 20 Hz; 200 μA). RNA isolated processed microarray-based 4 hours after TES; differentially expressed genes from...
To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration light-exposed rats.Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes TES, whereas SHAM identical sham 2 hours before exposure to bright light with 16,000 lux; healthy animals 3) served as controls for histology. At baseline and weekly 3 consecutive weeks, dark- light-adapted electroretinography was used assess function. Analysis response versus...
To evaluate electrically evoked phosphene thresholds (EPTs) in healthy subjects and patients with retinal disease to assess repeatability possible correlations common ophthalmologic tests.In all, 117 individuals participated: (n = 20) retinitis pigmentosa (RP, n 30), Stargardt's (STG, 14), artery occlusion (RAO, 20), nonarteritic anterior ischemic optic neuropathy (NAION, 16), primary open-angle glaucoma (POAG, 17). EPTs were determined at 3, 6, 9, 20, 40, 60, 80 Hz 5 + 5-ms biphasic current...
The purpose of this study was to investigate the safety and efficacy transcorneal electrical stimulation (TES) in patients suffering from retinal artery occlusion (RAO). Twelve with central one patient branch RAO (age 25–84 years, median 74 years) were enrolled prospective, randomized, sham-controlled study. diagnosed 10 days 17 months prior participation. Patients treated TES (5 ms positive followed by 5 negative biphasic pulses at 20 Hz; applied DTL electrodes) for 30 min once a week 6...
Background The study aimed to quantify changes of the optic nerve head (ONH) during exposure high altitude and assess a correlation with acute mountain sickness (AMS). This work is related Tuebingen High Altitude Ophthalmology (THAO) study. Methodology/Principal Findings A confocal scanning laser ophthalmoscope (cSLO, Heidelberg Retina Tomograph, HRT3®) was used at ONH in 18 healthy participants before, after rapid ascent (4559 m). Slitlamp biomicroscopy for clinical disc evaluation; AMS...
<h3>Aim</h3> To investigate changes in colour discrimination as a result of chronic hypoxic exposure induced by extreme altitudes (above 8000 m) during an expedition to Mt Everest. <h3>Methods</h3> Colour thresholds for tritan, protan and deutan axes were measured extensively two male participants (four eyes) Everest, using quantitative, computer controlled psychophysical vision test (modified version the Cambridge Test). The tests carried out over period 54 days at 1300 m, 3450 4410 5060...
Background This study aimed to quantify structural and functional changes at the macula during acute exposure high altitude assess their structure/function relationship. work is related Tuebingen High Altitude Ophthalmology (THAO) study. Methodology/Principal Findings Spectral domain optical coherence tomography microperimetry were used of central retinal structure function in 14 healthy subjects (4559 m). High-resolution volume scans fundus-controlled posterior pole performed addition...
should be distinguished from rationing and that parsimony is a virtue to which all physicians strive in the practice of medicine. 2owever, we disagree with statement article "Both parsimonious medicine aim reduce resource use."The medical provide care necessary for patient's good, not use (although it may addition preserve resources 3 )-a difference intention helps form foundation ethical distinction between rationing.We suspect Tilburt Cassel might agree because they note role beneficence...
High altitude provides environmental conditions with dry air and cold temperatures that may facilitate the development of eye symptoms. This study investigated, for first time, quality tear film during high exposure in healthy subjects. is related to Tübingen Altitude Ophthalmology (THAO) study.Tear osmolarity (TFO), breakup time (TBUT), Schirmer I II were used assess properties under standardized 14 subjects on day 1, 2, 4 at Capanna Margherita (CM; 4559 m, Italy) compared baseline...
The most common altitude-related symptom, high-altitude headache (HAH), has recently been suggested to originate from restricted cerebral venous drainage in the presence of increased inflow caused by hypoxia. In support this novel hypothesis, retinal distension was shown correlate with degree HAH. We quantified for first time vessel diameter changes at 4559 m using infrared fundus images obtained a state art Spectralis™ HRA+OCT semiautomatic VesselMap 1® software. High-altitude exposure...
Although hypoxia plays a key role in the pathophysiology of many common and well studied retinal diseases, little is known about effects high-altitude on function. The aim present study was to assess function during exposure using electroretinography (ERG). This work related Tübingen High Altitude Ophthalmology (THAO) study. Electroretinography performed 14 subjects Tübingen, Germany (341 m) at high altitude La Capanna Regina Margherita, Italy (4,559 an extended protocol functional integrity...
Purpose.: This study aimed to quantify the impact of exposure high altitude on individual layers cornea in regard central corneal thickness (CCT) and geometry anterior chamber angle (ACA). work is related Tübingen High Altitude Ophthalmology study. Methods.: Anterior segment spectral domain optical coherence tomography was used changes ACA opening distance (AOD). Peripheral oxygen saturation, heart rate, scores acute mountain sickness (AMS) were assessed 14 healthy subjects at baseline (341...
Duchenne's muscular dystrophy (DMD) is a severe progressive myopathy caused by mutations in the DMD gene leading to deficiency of dystrophin protein. Due ongoing muscle necrosis respiratory muscles late-stage associated with insufficiency and chronic hypoxia (CH). To understand effects CH on dystrophin-deficient vivo, we exposed Drosophila model for (dmDys) during 16-day ascent summit Mount Denali/McKinley (6194 meters above sea level). Additionally, dmDys wild type (WT) flies were also...
Hypoxia induces a myriad of changes including an increase in hematocrit due to erythropoietin (EPO) mediated erythropoiesis. While hypoxia is importance physiologically and clinically, lacunae exist our knowledge the systemic temporal gene expression occurring blood during exposure recovery from hypoxia. To identify these profiling was conducted on obtained cohorts C57Bl-10 wild type mice that were maintained at normoxia (NX), exposed for two weeks normobaric chronic (CH) or CH followed by...
Willmann, Gabriel, Kai Schommer, Maximilian Schultheiss, M. Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, and Andreas Schatz. Effect of high altitude exposure on intraocular pressure using Goldmann applanation tonometry. High Alt Med Biol. 18:114-120, 2017.The aim the study was to quantify changes (IOP) during 4559 m state-of-the-art method tonometry for IOP measurement detect correlations between acute mountain sickness (AMS) in a prospective manner.IOP measured tonometer AT...
Purpose: This study aimed to quantify the impact of high altitude on choroidal thickness and relate changes altered blood flow clinical parameters acute mountain sickness (AMS). work is related Tübingen High Altitude Ophthalmology (THAO) study. Methods: Enhanced depth imaging spectral-domain optical coherence tomography was used macular layer thickness. Peripheral oxygen saturation, heart rate, AMS scores were assessed in eight healthy subjects at baseline (altitude, 341 m) (4559 for...
The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure healthy subjects due the effects hypobaric hypoxia. This is related Tübingen High Altitude Ophthalmology study.Visual Weber CS were tested monocularly using Freiburger Visual Acuity Contrast Test under standardised conditions 14 at Capanna Margherita (4559 m, Italy) compared with baseline measurements (341 Germany). Intraindividual differences between follow-up...