The efficacy of two novel artificial vitreous body substitutes (VBS) consisting highly biocompatible thiolated cross-linked hyaluronic acid (HA)-based hydrogels in comparison to silicone oil a model retinal detachment was investigated. Pars plana vitrectomy (23G) performed the right eye 24 pigmented rabbits. Retinal quadrants induced by creating small retinotomy near vascular arcade and injecting balanced salt solution (BSS) subretinally. retina reattached air, which followed increasing...

Background The study aimed to quantify changes of the optic nerve head (ONH) during exposure high altitude and assess a correlation with acute mountain sickness (AMS). This work is related Tuebingen High Altitude Ophthalmology (THAO) study. Methodology/Principal Findings A confocal scanning laser ophthalmoscope (cSLO, Heidelberg Retina Tomograph, HRT3®) was used at ONH in 18 healthy participants before, after rapid ascent (4559 m). Slitlamp biomicroscopy for clinical disc evaluation; AMS...

Background This study aimed to quantify structural and functional changes at the macula during acute exposure high altitude assess their structure/function relationship. work is related Tuebingen High Altitude Ophthalmology (THAO) study. Methodology/Principal Findings Spectral domain optical coherence tomography microperimetry were used of central retinal structure function in 14 healthy subjects (4559 m). High-resolution volume scans fundus-controlled posterior pole performed addition...

To evaluate the sulcus anatomy and possible correlations between diameter white-to-white (WTW) in pseudophakic eyes, data that may be important stability of add-on intraocular lenses (IOLs).University Eye Hospital, Tuebingen, Germany.Case series.In axial length (AL) horizontal WTW were measured by IOLMaster device. Cross-sectional images obtained with a 50 MHz ultrasound biomicroscope on 4 meridians: vertical, (180 degrees), temporal oblique, nasal oblique. Sulcus-to-sulcus (STS),...

should be distinguished from rationing and that parsimony is a virtue to which all physicians strive in the practice of medicine. 2owever, we disagree with statement article "Both parsimonious medicine aim reduce resource use."The medical provide care necessary for patient's good, not use (although it may addition preserve resources 3 )-a difference intention helps form foundation ethical distinction between rationing.We suspect Tilburt Cassel might agree because they note role beneficence...

High altitude provides environmental conditions with dry air and cold temperatures that may facilitate the development of eye symptoms. This study investigated, for first time, quality tear film during high exposure in healthy subjects. is related to Tübingen Altitude Ophthalmology (THAO) study.Tear osmolarity (TFO), breakup time (TBUT), Schirmer I II were used assess properties under standardized 14 subjects on day 1, 2, 4 at Capanna Margherita (CM; 4559 m, Italy) compared baseline...

The most common altitude-related symptom, high-altitude headache (HAH), has recently been suggested to originate from restricted cerebral venous drainage in the presence of increased inflow caused by hypoxia. In support this novel hypothesis, retinal distension was shown correlate with degree HAH. We quantified for first time vessel diameter changes at 4559 m using infrared fundus images obtained a state art Spectralis™ HRA+OCT semiautomatic VesselMap 1® software. High-altitude exposure...

Although hypoxia plays a key role in the pathophysiology of many common and well studied retinal diseases, little is known about effects high-altitude on function. The aim present study was to assess function during exposure using electroretinography (ERG). This work related Tübingen High Altitude Ophthalmology (THAO) study. Electroretinography performed 14 subjects Tübingen, Germany (341 m) at high altitude La Capanna Regina Margherita, Italy (4,559 an extended protocol functional integrity...

Purpose.: This study aimed to quantify the impact of exposure high altitude on individual layers cornea in regard central corneal thickness (CCT) and geometry anterior chamber angle (ACA). work is related Tübingen High Altitude Ophthalmology study. Methods.: Anterior segment spectral domain optical coherence tomography was used changes ACA opening distance (AOD). Peripheral oxygen saturation, heart rate, scores acute mountain sickness (AMS) were assessed 14 healthy subjects at baseline (341...

Purpose: In surgical ophthalmology, the treatment of complicated retinal and vitreous diseases is one central challenges. For this purpose, body removed as part standard therapy replaced by a temporary tamponade to stabilize position retina. Since tamponading properties previous materials such silicone oils, gases, or semi-fluorinated alkanes are combination their surface tension buoyancy vector, they cannot completely fill cavity. The aim work was test in vivo novel substitute (ViBos...

Willmann, Gabriel, Kai Schommer, Maximilian Schultheiss, M. Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, and Andreas Schatz. Effect of high altitude exposure on intraocular pressure using Goldmann applanation tonometry. High Alt Med Biol. 18:114-120, 2017.The aim the study was to quantify changes (IOP) during 4559 m state-of-the-art method tonometry for IOP measurement detect correlations between acute mountain sickness (AMS) in a prospective manner.IOP measured tonometer AT...

Purpose: This study aimed to quantify the impact of high altitude on choroidal thickness and relate changes altered blood flow clinical parameters acute mountain sickness (AMS). work is related Tübingen High Altitude Ophthalmology (THAO) study. Methods: Enhanced depth imaging spectral-domain optical coherence tomography was used macular layer thickness. Peripheral oxygen saturation, heart rate, AMS scores were assessed in eight healthy subjects at baseline (altitude, 341 m) (4559 for...

The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure healthy subjects due the effects hypobaric hypoxia. This is related Tübingen High Altitude Ophthalmology study.Visual Weber CS were tested monocularly using Freiburger Visual Acuity Contrast Test under standardised conditions 14 at Capanna Margherita (4559 m, Italy) compared with baseline measurements (341 Germany). Intraindividual differences between follow-up...

Objectives To explore the effect of ketamine-xylazine anesthesia on light-induced retinal degeneration in rats. Methods Rats were anesthetized with ketamine and xylazine (100 5 mg, respectively) for 1 h, followed by a recovery phase 2 h before exposure to 16,000 lux environmental illumination h. Functional assessment electroretinography (ERG) morphological vivo imaging (optical coherence tomography), histology (hematoxylin/eosin staining, TUNEL assay) immunohistochemistry (GFAP rhodopsin...

Background/aims The study aims to investigate changes in the optic nerve sheath diameter (ONSD) at high altitude and assess correlation disc oedema (ODE) acute mountain sickness (AMS). This investigation is part of Tübingen High Altitude Ophthalmology study. Methods Fourteen volunteers ascended 4559 m for 4 days before returning low altitude. Ultrasonography ONSD, quantification parameters using a scanning laser ophthalmoscope fluorescein angiography were performed 341 Pearson’s coefficient...

Abstract Purpose X‐linked juvenile retinoschisis (XLRS) is the most common maculopathy in men and caused by mutations gene encoding retinoschisin ( RS1 ). Evidence literature on therapeutic effect of carboanhydrase inhibitors (CAIs) to treat schisis formation retina has remained equivocal. Here, we evaluate CAI dorzolamide structural functional disease progression mouse model for XLRS Rs1h −/y Methods mice were treated unilaterally with eye drops (Trusopt ® 20 mg/mL) every 12 h 2 weeks...

Purpose This study aimed to quantify the pupillary light reaction during high altitude exposure using state of art Compact Integrated Pupillograph (CIP) and investigate a potential correlation altered pupil with severity acute mountain sickness (AMS). work is related Tübingen High Altitude Ophthalmology (THAO) study. Methods Parameters dynamics (initial diameter, amplitude, relative latency, constriction velocity) were quantified in 14 healthy volunteers at baseline (341 m) (4559 over...

In Brief Purpose: To investigate the biocompatibility of methyl blue and aniline as vital dyes for vitreoretinal surgery in an vivo rat model to evaluate effect these on retinal structure function. Methods: Adult Brown–Norway rats received intravitreal injections 0.1%, 0.2%, 2% or dissolved balanced salt solution with serving a control. Retinal toxicity was assessed 7 days thereafter by means ganglion cell counts, light microscopy, electroretinography. Results: No significant decrease counts...