A5066671907- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Vascular Malformations Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Visual perception and processing mechanisms
- Vasculitis and related conditions
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Traumatic Ocular and Foreign Body Injuries
- Retinopathy of Prematurity Studies
Knappschaftsklinikum Saar
2016-2025
University of Tübingen
2024-2025
STZ eyetrial
2020-2025
Ophthalmology Clinic
2022
Sulzer (Switzerland)
2021
University of Basel
2020-2021
Fraunhofer Institute for Biomedical Engineering
2019
University of Rostock
2011-2016
Purpose: To study alginate- and hyaluronic acid–based hydrogels in vitro as vitreous substitutes. Methods: Biopolymeric based on high-molecular alginate (0.5% 1.0%) acid (1.0% Healaflow) were compared with extracted human bodies silicone oil (SIL-5000) regarding their optical properties (refractive index, transmission) viscoelastic characteristics (storage modulus G′, loss G″). The cytotoxic (metabolic activity, apoptosis) antiproliferative profiles determined using cultured fibroblasts,...
To determine the viscoelasticity of human vitreous bodies and its changes with age in order to benefit understanding therapy vitreoretinal diseases.In a postmortem study, 190 were extracted from 33- 92-year-old donors, analyzed regard their viscoelastic properties via dynamic mechanical analyses, compared bovine porcine vitreous. Postmortem intervals donor-related parameters examined as potential influencing viscoelasticity. Dynamic moduli different hyaluronic acid (HA) solutions well...
Der zunehmende bürokratische Aufwand im klinischen Alltag beeinträchtigt die Arzt-Patienten-Kommunikation (APK). Eine effektive Nutzung von digitalen Technologien, wie z. B. eine automatisierte semantische Spracherkennung (ASR) mit automatisierter Informationsextraktion diagnostisch relevanter Informationen, kann Abhilfe schaffen. Ziel war es zu ermitteln, inwieweit sich in Verbindung einer semantischen zur automatisierten Dokumentation des Arzt-Patienten-Dialoges (ADAPI) am Beispiel der...
Purpose: To analyze the clinical outcome of organ-cultured endothelium-outward preloaded DMEK (pDMEK) using RAPID cartridge. Methods: This prospective study included 80 eyes patients who received a pDMEK. Best-corrected visual acuity (BCVA), endothelial cell count (ECC), and central corneal thickness were measured preoperatively 4 to 6 weeks, 3 months, 1 year postoperatively. The difficulty graft preparation implantation, rebubbling, re-DMEK frequency evaluated. Results: time was 5.3 ± 1.2...
Purpose To evaluate time to first additional treatment following intravitreal 0.19 mg fluocinolone acetonide (FAc) in non-infectious uveitis with posterior segment involvement (NIU-PS) a real-world setting.
The aim of this study was to evaluate the pupil size normal subjects at different illumination levels with a novel pupillometer. healthy participants measured an infrared-video PupilX pupillometer (MEye Tech GmbH, Alsdorf, Germany) five (0, 0.5, 4, 32, and 250 lux). Measurements were performed by same investigator. Ninety images executed during measurement period 3 seconds. absolute linear camera resolution approximately 20 pixels per mm. This cross-sectional analysed 490 eyes 245 (mean age:...
To characterize the biophysical properties of an artificial vitreous body substitute (VBS), which consists a biocompatible, cross-linked, hyaluronic acid (HA)-based hydrogel, by analysing VBS's influence on intraocular pressure (IOP) and retinal integrity in distinct ex vivo eye models order to evaluate its potential for biocompatibility testing.Pig eyes were obtained immediately postmortem, VBS was injected after core-vitrectomy. IOP followed 24 h (n = 5). investigated using isolated bovine...
Mitochondrial network functionality is vital for glucose-stimulated insulin secretion in pancreatic beta cells. Altered mitochondrial dynamics cells are thought to trigger the development of type 2 diabetes mellitus. Fission protein 1 (Fis1) might be a key player this process. Thus, aim study was investigate morphology dependence cell function, after knockdown and overexpression Fis1. We demonstrate that glucose-unresponsive with impaired (INS1-832/2) showed decreased compared...
Purpose: In surgical ophthalmology, the treatment of complicated retinal and vitreous diseases is one central challenges. For this purpose, body removed as part standard therapy replaced by a temporary tamponade to stabilize position retina. Since tamponading properties previous materials such silicone oils, gases, or semi-fluorinated alkanes are combination their surface tension buoyancy vector, they cannot completely fill cavity. The aim work was test in vivo novel substitute (ViBos...
A proof of principle study showed that the TheraMon® -microsensor can reliably measure wearing times glasses and occlusion patches while having no discomfort for bearer. The goal this was to identify specific temperature profiles in a larger patient group microsensor with an patch on eye, forehead or trouser pocket.Temperature measurements microsensors were performed at orbital rim trousers pocket 20 healthy adults. analysed comparing three locations using repeated-measures anova 0.050...
Purpose: To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF6) tamponade.Methods: Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber 54 eyes receiving SF6 and injection. A post-hoc matched revealed no statistically significant differences between groups. The main outcome measurements were complication rate, including intra- postoperative complications graft...
Purpose: Descemet membrane endothelial keratoplasty (DMEK) has been improved over the last decade. The aim of this study was to compare clinical outcome recently introduced liquid bubble method compared standard manual preparation.Methods: This retrospective evaluated 200 patients after DMEK surgery using two different graft preparation techniques. Ninety-six were prepared by dissection and 104 novel technique. mean follow-up time 13.7 months (SD ± 8, range 6–36 months).Results: Best...
Abstract Purpose Hydrogel‐based vitreous substitutes have the potential to overcome limitations of current clinically used endotamponades. With goal entering clinical trials, present study aimed (I) transfer material synthesis hyaluronic acid–based hydrogels into a routine, pharmaceutical‐appropriate production and (II) evaluate properties in terms regulations for medical devices (MDR/ISO standards). Methods The multistep manufacturing process substitutes, including modification acid with...