A5008582328- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Neuroscience and Neural Engineering
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- EEG and Brain-Computer Interfaces
- High Altitude and Hypoxia
- Vascular Malformations Diagnosis and Treatment
- Traumatic Ocular and Foreign Body Injuries
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Retinopathy of Prematurity Studies
- Advanced Memory and Neural Computing
- Advanced biosensing and bioanalysis techniques
- Ocular Disorders and Treatments
STZ eyetrial
2016-2025
University of Tübingen
2015-2024
Peninsula Library System
2024
Universitätsaugenklinik Magdeburg
2004-2024
Universitätsklinikum Tübingen
2002-2023
Ophthalmology Clinic
2012-2023
University Children's Hospital Tübingen
2002-2022
Universitäts-Augenklinik Bonn
1996-2021
Universitätsklinik für Augenheilkunde
2013-2020
TH Bingen University of Applied Sciences
2003-2018
A light-sensitive, externally powered microchip was surgically implanted subretinally near the macular region of volunteers blind from hereditary retinal dystrophy. The implant contains an array 1500 active microphotodiodes (‘chip’), each with its own amplifier and local stimulation electrode. At implant's tip, another 16 wire-connected electrodes allows light-independent direct testing neuron–electrode interface. Visual scenes are projected naturally through eye's lens onto chip under...
This study aims at substituting the essential functions of photoreceptors in patients who are blind owing to untreatable forms hereditary retinal degenerations. A microelectronic neuroprosthetic device, powered via transdermal inductive transmission, carrying 1500 independent microphotodiode-amplifier-electrode elements on a 9 mm(2) chip, was subretinally implanted nine patients. Light perception (8/9), light localization (7/9), motion detection (5/9, angular speed up 35 deg s(-1)), grating...
A subretinal visual implant (Alpha IMS, Retina Implant AG, Reutlingen, Germany) was implanted in 29 blind participants with outer retinal degeneration an international multicenter clinical trial. Primary efficacy endpoints of the study protocol were a significant improvement activities daily living and mobility to be assessed by tasks, recognition mobility, or combination thereof. Secondary acuity/light perception and/or object (clinicaltrials.gov, NCT01024803). During up 12 months...
Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration an interim analysis two ongoing prospective clinical trials. Methods: The visual prosthesis AMS (Retina Implant AG, Reutlingen, Germany) was implanted 15 blind patients with hereditary degenerations at four study sites follow-up period 12 months (www.clinicaltrials.gov NCT01024803 NCT02720640). Functional outcome measures included...
Achromatopsia linked to variations in the CNGA3 gene is associated with day blindness, poor visual acuity, photophobia, and involuntary eye movements owing lack of cone photoreceptor function. No treatment currently available.To assess safety vision outcomes supplemental therapy adeno-associated virus (AAV) encoding (AAV8.CNGA3) patients CNGA3-linked achromatopsia.This open-label, exploratory nonrandomized controlled trial tested vector AAV8.CNGA3 administered by subretinal injection at a...
purpose. The penetration of intravitreally injected bevacizumab in its commercial formulation (Avastin; Roche, Grenzach, Germany) through the retina was studied, to determine whether a full-length antibody would be able penetrate as easily an fragment. methods. Six cynomolgus monkeys (Macaca fascicularis) were used this study. Two compositions intravitreal injection into right eyes performed: one with Avastin (group 1, four animals) and other labeled 125I 2, animal). animals group 1 killed...
That vascular endothelial growth factor (VEGF) plays a major role in inflammatory angiogenesis has been well established. This pilot study was designed to evaluate experimental treatment with bevacizumab eyedrops corneal neovascularization induced by alkali burn. The feasibility of topical administration, cell viability and penetration were investigated an animal model.Eighteen chinchilla bastard rabbit corneas injured 1 m NaOH divided into three groups: untreated, early late groups....
To assess the safety of transcorneal electrical stimulation (TES) and explore its efficacy in various subjective objective parameters visual function patients with retinitis pigmentosa (RP).Twenty-four this prospective, randomized, partially blinded, good-clinical-practice study underwent TES (5-ms biphasic pulses; 20 Hz; DTL electrodes) 30 minutes per week for 6 consecutive weeks. The were randomly assigned to one three groups: sham, 66%, or 150% individual phosphene threshold (EPT). Visual...
Purpose: To investigate shedding and biodistribution characteristics of recombinant adeno-associated virus serotype 8 (rAAV8) after single-dose subretinal or intravitreal injection in nonhuman primates (NHP, Macaca fascicularis) as a surrogate for environmental hazard patient safety. Methods: In study regulatory submission, 22 NHP were divided into four cohorts receiving either single injections vehicle clinical grade rAAV8 (1 × 1011 1 1012 vector genomes [vg]) versus application vg. Viral...
Choroideremia (CHM) is a rare, degenerative, genetic retinal disorder resulting from mutation of the CHM gene, leading to an absence functional ras-associated binding escort protein 1 (REP1). There currently no approved treatment for CHM.To assess safety and efficacy gene therapy with adeno-associated virus vector (AAV2) designed deliver version (AAV2-REP1) patients choroideremia.Tübingen Gene Therapy (THOR) was single-center, phase 2, open-label randomized clinical trial. Data were...
To determine long-term safety and efficacy outcomes of a subretinal gene therapy for CNGA3-associated achromatopsia. We present data from an open-label, nonrandomised controlled trial (NCT02610582).Details the study design have been previously described. Briefly, nine patients were treated in three escalating dose groups with AAV8.CNGA3 between November 2015 October 2016. After first year, seen on yearly basis. Safety assessment constituted primary endpoint. On secondary level, multiple...
Voretigene neparvovec (VN) is the first and only subretinal gene therapy approved by Food Drug Administration European Medicines Agency. Real-world application has started in 2018 patients with vision impairment due to biallelic retinal pigment epithelium (RPE) 65 mutation-associated inherited degenerations. Herein, we evaluated development of atrophy within a single-centre patient cohort treated VN.13 eyes eight VN were retrospectively analysed for areas over period 6-24 months following...
Meta-analyses of case series non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question.
To report the histopathologic features of surgically removed submacular tissue from an elderly patient with a pattern polypoidal choroidal vasculopathy on indocyanine green angiography.Clinical examination including fluorescein and angiography light microscopy surgical specimen.A thick yellow proteinaceous subretinal fluid was seen in right macula 81-year-old white man. Fluorescein indicated progressive leakage undetermined source apart few focal hyperfluorescent points. Indocyanine showed...
<h3>Background:</h3> Due to low energy levels in microphotodiode-based subretinal visual prostheses, an external power supply is mandatory. We report on the surgical feasibility and functional outcome of extraocular part approach connect a prosthesis extracorporeal connector retro-auricular space via trans-scleral, transchoroidal cable. <h3>Methods:</h3> Seven volunteers with retinitis pigmentosa received active implant; was supplied by gold wires trans-sclerally, transchoroidally implanted...