A5020406384- Retinal and Optic Conditions
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Epilepsy research and treatment
- Glaucoma and retinal disorders
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Corneal Surgery and Treatments
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Retinal Diseases and Treatments
- Cleft Lip and Palate Research
- Pharmacological Effects and Toxicity Studies
- Cancer-related cognitive impairment studies
- Spinal Dysraphism and Malformations
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Genetic Syndromes and Imprinting
- Infant Development and Preterm Care
- Functional Brain Connectivity Studies
- Retinal and Macular Surgery
Michigan Medicine
2024
University of Tübingen
2024
STZ eyetrial
2020-2024
Rotterdam Eye Hospital
2024
University of Michigan
2023-2024
Peninsula Library System
2024
University Medical Center Hamburg-Eppendorf
2017-2022
Universität Hamburg
2017-2022
Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg
2022
Universitätsklinikum Tübingen
2021-2022
Journal Article THE COMPARISON OF SMALL-SIZE RECTANGLE AND CHECKERBOARD STIMULATION FOR EVALUATION DELAYED VISUAL EVOKED RESPONSES IN PATIENTS SUSPECTED MULTIPLE SCLEROSIS Get access M. HENNERICI, HENNERICI Department of Neurology, University FreiburgD-7800 Freiburg i. Br., West Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar D. WENZEL, WENZEL H.-J. FREUND Brain, Volume 100, Issue 1, 1977, Pages 119–136, https://doi.org/10.1093/brain/100.1.119...
To determine the dynamics of allelic-specific expression during mouse development, we analyzed RNA-seq data from 23 F1 tissues different developmental stages, including 19 female allowing X chromosome inactivation (XCI) escapers to also be detected. We demonstrate that allelic arising genetic or epigenetic differences is highly tissue-specific. find tissue-specific strain-biased gene may regulated by enhancers post-transcriptional in stability between alleles. escape X-inactivation...
Abstract Background ChatGPT is a free artificial intelligence (AI)-based natural language processing tool that generates complex responses to inputs from users. Objectives To determine whether able generate high-quality patient-submitted questions in the patient portal. Methods Patient-submitted and corresponding their dermatology physician were extracted electronic medical record for analysis. The input into (version 3.5) outputs analysis, with manual removal of verbiage pertaining...
Meta-analyses of case series non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question.
Preserflo MicroShunt is a novel microinvasive bleb forming device for the treatment of primary open-angle glaucoma. The intermediate- and long-term success impact this procedure on corneal endothelial cell density remain to be investigated.
<b><i>Objective: </i></b> Classic infantile spinal muscular atrophy (SMA) is believed to be a purely motor disorder, affecting neurons of the anterior horn and nuclei lower cranial nerves. Other organ malformations or peripheral nerve involvement have been regarded as exclusion criteria for SMA. Whether SMN protein deficiency can also lead loss sensory has not systematically addressed. <b><i>Methods: The authors evaluated sural biopsies 19 patients with SMA varying severity. diagnosis was...
iPSCs derived from fibroblasts with mutant type VII collagen were genetically corrected and used as cell therapy in mice recessive dystrophic epidermolysis bullosa.
PR homology domain-containing member 12 (PRDM12) belongs to a family of conserved transcription factors implicated in cell fate decisions. Here we show that PRDM12 is key regulator sensory neuronal specification Xenopus. Modeling human mutations cause hereditary and autonomic neuropathy (HSAN) revealed remarkable conservation the mutated residues evolution. Expression wild-type Xenopus induced expression markers, which was reduced using various mutants. In Drosophila, identified Hamlet as...
Acute central retinal artery occlusion (CRAO) induces ischaemic oedema. The purpose of this study was to define sensitivity and specificity optical coherence tomography (OCT) based thickness analysis in determining ischaemia onset CRAO.The relative increase (RRTI) comparison with the fellow eye analysed retrospectively OCT scans 66 patients diagnosed CRAO between January 2010 December 2019 within 48 hr onset. natural course RRTI OCT-based determination identifying 4.5 using were...
Abstract Purpose Time is the key criterion in management of non‐arteritic central retinal artery occlusion (NA‐CRAO). However, precise onset vision loss often difficult to determine. This study aimed evaluate temporal changes thickness acute NA‐CRAO and potential this parameter be used as a surrogate marker estimate ischaemia. Methods Optical coherence tomography was continuously assess oedema progression rate six porcine eyes. Additionally, retrospective analysis 12 patients with performed...
To investigate inner retinal hyperreflectivity on optical coherence tomography (OCT) as a potential biomarker indicating acute central artery occlusion (CRAO).A total of 56 patients at two university hospitals with CRAO (symptom onset ≤48 h) were included in this retrospective study. The intensity the layers was determined both eyes and relationship between symptom layer OCT scans compared to unaffected fellow eye analyzed. Several differential diagnoses [central vein occlusion, anterior...
Metallic plates are known for their passive intraosseous transmission in the growing skull. To avoid plate removal, resorbable material with strength comparable to that of metallic and predictable resorption would be desirable. This should accomplished without causing inflammatory complications foreign body reactions often seen highly crystalline poly-L-lactic acid or pure polyglycolic implants. In an animal experiment four young Göttingen minipigs, acid/polyglycolic copolymer LactoSorb was...
The aim of the study was to investigate effect carnitine supplementation in valproic acid (VPA) treated patients presenting with increased plasma ammonia concentrations. Plasma concentrations were recorded 69 children and young adults on VPA monotherapy (25.6 ± 9.2 mg VPA/kg per day; mean concentration 68.8 27.6 μg/1). Their 80.2 32.1 μg/dl (median 73.1/i,g/dl), A total 24 (35.3%) >80 considered hyperammonaemic. Of these, 15/24 (22.1 %) showed > 100 μg/dl, even up 194 μg/dl. In 48/69...
Our retrospective analysis of growth and pubertal development includes 109 children adults with meningomyelocele (MMC) (52 M, 57 F) aged 3.2‐21.0 years (median 8.9 years). Anthropometric data, growth‐retarding factors data on were analysed in comparison to the normal population using standards from Prader et al. (1). The results (mean ± SD) as follows. Fifty patients (46.8%) had short stature (height SDS for chronological age (SDS CA)< ‐2). supine length was influenced by level lesion CA:...
Acute central retinal artery occlusion (CRAO) induces a time-dependent increase in thickness. By manually measuring the relative thickness (RRTI) comparison to contralateral eye based on optical coherence tomography (OCT), ischemia onset within past 4.5 hours could be determined with 100% sensitivity and 94.3% specificity. To enable examiner-independent quicker diagnostics, we analyzed RRTI using automatic measurement. In this retrospective study, 28 eyes were evaluated an acute CRAO (<46...
This study was designed to detect vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-1) in follicular fluid specimens evaluate the importance of sVEGFR-1 with respect ovarian response gonadotrophin stimulation. A total 69 patients treated for IVF recombinant human follicle stimulating hormone (FSH). Concentrations VEGF were quantified fluids from oocyte retrievals. Patients designated three groups number harvested oocytes: group A, 1–5 oocytes; B, 6–10 C, >10 oocytes....
OBJECTIVE: The aim of the present study was to investigate role adrenomedullin (ADM) as a hypoxia-inducible marker clinically relevant tIssue hypoxia in acute birth asphyxia term newborn infants. METHODS: For this purpose, ADM mRNA determined human placental 20 pregnancies complicated by (pH and base deficit values, clinical score). In addition, measured leukocytes asphyxiated infants during first 12 h life (n=12). Controls were available from ten healthy pregnancies. vitro, expression...