A5028309097- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Ocular and Laser Science Research
- Connexins and lens biology
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Corneal Surgery and Treatments
- Health and Medical Studies
- Photoacoustic and Ultrasonic Imaging
- Photoreceptor and optogenetics research
- Botulinum Toxin and Related Neurological Disorders
- Drug-Induced Ocular Toxicity
- Retinopathy of Prematurity Studies
- Neonatal Respiratory Health Research
- Medical Practices and Rehabilitation
- Corneal surgery and disorders
- Healthcare Operations and Scheduling Optimization
- Systemic Lupus Erythematosus Research
Medizinische Hochschule Hannover
2020-2025
Ophthalmology Clinic
2025
Hochschule Hannover
2025
Hannover Re (Germany)
2024
University of Lübeck
2015-2022
University Hospital Schleswig-Holstein
2015-2022
Kiel University
2010-2021
Clinical Research Center Kiel
2019-2020
University Medical Center
2017
Universitäts Hautklinik Kiel
2017
Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration an interim analysis two ongoing prospective clinical trials. Methods: The visual prosthesis AMS (Retina Implant AG, Reutlingen, Germany) was implanted 15 blind patients with hereditary degenerations at four study sites follow-up period 12 months (www.clinicaltrials.gov NCT01024803 NCT02720640). Functional outcome measures included...
Lidocaine applied systemically or locally attenuates neuropathic pain in patients. Here we tested the hypothesis that ectopic activity injured afferent A- C-fibers is suppressed by lidocaine. In rats sural nerve (skin nerve) lateral gastrocnemius-soleus (muscle was crushed. Four to 11 days after crush lesion fibers were isolated from lesioned nerves bundles rostral injury site. Ongoing recorded 75 A-fibers N=43, skin N=32) and 69 N=30, N=39). Most functionally characterized their responses...
To investigate the effect of selective retina therapy (SRT) on release AMD-relevant cell mediators, such as matrix metalloproteinases (MMPs), VEGF, and pigment epithelium derived factor (PEDF) using different laser spot sizes densities.Porcine RPE-choroid explants were treated with a pulsed 532 nm Nd:YAG (1) large sizes, (2) small high-density (hd) treatment, (3) low-density (ld) treatment. Explants cultivated in modified Ussing chambers. RPE regeneration death investigated by calcein-AM...
To investigate the effect of thermal stimulation retina (TS-R) on Bruch's membrane (BrM) thickness in age-related macular degeneration (AMD) mouse models as a novel concept for prophylaxis and treatment dry AMD.Two knockout AMD models, B6.129P2-Apoetm1Unc/J (ApoE-/-) B6.129X1-Nfe2I2tm1Ywk/J (NRF2-/-), were chosen. One randomized eye each four different groups (two age, two genotype) five mice was treated by TS-R (532 nm, 10-ms duration, 50-μm spot size), fellow served control. Laser power...
Selective retina therapy (SRT) targets the retinal pigment epithelium (RPE) with pulsed laser irradiation by inducing microbubble formation (MBF) at intracellular melanin granula, which leads to selective cell disruption. The following wound healing process rejuvenates chorio-retinal junction. Pulse energy thresholds for RPE effects vary intra- and interindividually. We present evaluation of an algorithm that processes backscattered treatment light detect MBF as indicator damage since these...
<h3>Purpose</h3> Retinal arterial macroaneurysms (RAMAs) are acquired dilations of branches the central retinal artery. Treatment depends on vision-limiting complications. We compare long-term visual acuity (VA) in three groups according to treatment. <h3>Methods</h3> 49 charts patients with RAMA were reviewed. 16 remained untreated, 15 received photocoagulation and 18 vitrectomy. Patients underwent full ophthalmological examinations up-to-date imaging. evaluated chosen therapy,...
<b><i>Purpose:</i></b> To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes macula-off detachment after silicone oil (SiO) or gas endotamponade. <b><i>Procedures:</i></b> Cross-sectional study of 40 rhegmatogenous that underwent vitrectomy. 20 received SiO tamponade and matched gas. 33 healthy fellow served as controls. Macular spectral domain OCT was performed automated detection the 5 inner subfields Early...
Challenges in practice-oriented teaching at university clinics are increasing. A lack of resources contrasts a growing number students. Digital lectures, seminars, and blended-learning concepts enable resource-efficient effective ophthalmology. To implement evaluate digital concept combining bedside the Department Ophthalmology Hannover Medical School (MHH). Following National Competence-Based Learning Objectives Catalogue for Medicine (NKLM), theoretical units were combined with practical...
Rhegmatogenous retinal detachment (RRD) is an ophthalmological emergency with increasing incidence in Germany. Despite established methods, perioperative positioning important to improve outcomes and avoid complications but may be challenging, particularly immobile patients. An analysis of the current trends surgical treatment practices for RRD Germany compared historical data from 2018 essential. online survey five hypothetical cases acute was distributed vitreoretinal surgeons via...
Background Glaucoma, a leading cause of blindness, is often driven by elevated intraocular pressure (IOP), which damages the optic nerve. Transscleral filtration surgery reduces IOP but frequently complicated excessive wound healing from Tenon fibroblasts (TFs), impeding aqueous humor absorption. Mitomycin C (MMC), used for over 30 years in ophthalmic surgeries, inhibits TF proliferation carries significant side effects, including hypotony, blebitis, and endophthalmitis, due to its...
The treatment guidelines for many macular diseases rely on frequent monitoring with optical coherence tomography (OCT). However, the burden of disease control leads to low therapy adherence in real life. OCT home would address this issue but requires an inexpensive and self-operable device. With self-examination low-cost full-field (SELFF-OCT), our group has introduced a novel technology that may fulfill both requirements. In pilot study, we report initial experiences clinical...
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype patients with AMD and focusses on device operability diagnostic accuracy compared established spectral-domain (SD-OCT).Prospective single-arm study.Tertiary care centre (University Eye...
Injury of limb nerves leading to neuropathic pain mostly affects deep somatic including muscle nerves. Here, we investigated the functional properties injured afferent fibers innervating lateral gastrocnemius-soleus 4-13 h [time period (TP) I] and 4-7 days (TP II) after nerve crush in anesthetized rats using neurophysiological recordings from either sciatic (165 A-, 137 C-fibers) or dorsal root L(5) (43 28 C-fibers). Ongoing activity responses mechanical thermal stimulation injury site were...
To investigate the effect of selective retina therapy (SRT) on age-related macular degeneration (AMD)-like alterations retinal pigment epithelium (RPE) and Bruch's membrane (BrM) in AMD mouse models as therapeutic approach for treatment dry AMD.In B6.129P2-Apoetm1Unc /J (ApoE-/-) B6.129X1-Nfe2I2 tm1Ywk (NRF2-/-), one randomized eye each groups 15 mice was treated by SRT (532 nm, 300 ms, ∼1.4-μs pulse, 100 Hz, 50-μm spot), fellow healthy C57BL/6J served controls. Clinical examinations were...
Adeno-associated viral transduction allows the introduction of nucleic fragments into cells and is widely used to modulate gene expressions in vitro vivo . It enables study genetic functions disease mechanisms and, more recently, serves as a tool for repair. To achieve optimal performance given cell type, selecting an appropriate serotype number virus particles per cell, also known multiplicity infection, critical. Fluorescent proteins are one common reporter genes visualize successfully...
This study evaluates the long-term effects of selective retina therapy (SRT) on retinal pigment epithelium (RPE) and neuroretina in patients with central serous chorioretinopathy. SRT was performed 36 using a Nd:YLF-Laser at 527 nm (R:GEN®, Lutronic, Goyang-Si, Republic Korea). A total 994 titration spots were examined up to three years' multimodal imaging. Leakage fluorescein angiography (FA) observed after 523 lesions resolved one month. not visible clinically, but appeared as brightly...
Retinal microvasculature is known to be altered in patients with Fabry disease (FD). We aimed investigate the long-term changes macular and explore a reliable retinal biomarker for treatment monitoring FD. Prospective study of 26 eyes FD followed up 48 months (mean 24, range 8–48). OCT angiography (OCTA) images (2.9 × 2.9 mm) were obtained using Heidelberg Spectralis II at baseline follow-up. Macular vessel area density (VAD, %) was measured three layers: superficial vascular plexus (SVP),...
Background/aims Patients with rhegmatogenous retinal detachment (RRD) who develop postoperative proliferative vitreoretinopathy (PVR) have been found to higher preoperative laser flare values than patients RRD do not this complication.Measurement of has therefore proposed as an objective, rapid and non-invasive method for identifying high-risk patients.The purpose our study was validate the use a predictor PVR risk in two additional patient cohorts, confirm sensitivity specificity...