A5010052038- Cardiac, Anesthesia and Surgical Outcomes
- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Travel-related health issues
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin C and Antioxidants Research
- Long-Term Effects of COVID-19
- Sulfur Compounds in Biology
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- Trauma and Emergency Care Studies
- Cardiovascular and Diving-Related Complications
- Metabolomics and Mass Spectrometry Studies
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Enhanced Recovery After Surgery
- Redox biology and oxidative stress
- Spaceflight effects on biology
- Circadian rhythm and melatonin
University Hospital Southampton NHS Foundation Trust
2017-2024
University of Southampton
2015-2024
NIHR Southampton Biomedical Research Centre
2018-2024
South Western Ambulance Service NHS Foundation Trust
2024
Southampton General Hospital
2019
NIHR Southampton Respiratory Biomedical Research Unit
2017-2018
University of Washington
2018
NIHR Clinical Research Network
2015
University of Oxford
2011-2012
John Radcliffe Hospital
2012
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Bärtsch, Andrew M. Luks, Martin J. MacInnis, Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. 2018 Acute Mountain Sickness Score. High Alt Med Biol 19:1-4, 2018.- (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, not closely related AMS. To...
Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, numerous analytical methods exist for the measurement of sulfur-containing species affected. However, uncertainty remains about their concentrations speciation cells/biofluids, perhaps part due to differences sample processing detection principles. Using ultrahigh-performance liquid chromatography combination electrospray-ionization tandem mass spectrometry we here outline a...
Considerable controversy remains about how much oxygen patients should receive during surgery. The 2016 World Health Organization (WHO) guidelines recommend that intubated a fractional inspired concentration (FIO2) of 0.8 throughout abdominal surgery to reduce the risk surgical site infection. However, this recommendation has been widely criticised by anaesthetists and evidence from other clinical contexts suggested giving high might worsen patient outcomes. This retrospective multi-centre...
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim this study was describe the relationship between physiological variables and incidence AMS during ascent 5300 m. A total 332 lowland-dwelling volunteers followed an identical profile on staggered treks. Self-reported symptoms were recorded daily using Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO
The chemical and functional interactions between Reactive Oxygen (ROS), Nitrogen (RNS) Sulfur (RSS) species allow organisms to detect respond metabolic environmental stressors, such as exercise altitude exposure. Whether redox markers constituents of this 'Reactive Species Interactome' (RSI) differ in concentration arterial venous blood is unknown. We hypothesised that measurements may provide useful insight into metabolic/redox regulation at the whole-body level would be consistent...
Classic teaching suggests that diminished availability of oxygen leads to increased tissue extraction yet evidence support this notion in the context hypoxaemia, as opposed anaemia or cardiac failure, is limited.At 75 m above sea level, and after 7-8 days acclimatization 4559 m, systemic [C(a-v)O2] was calculated five participants at rest peak exercise. Absolute by subtracting central venous content (CcvO2) from arterial [Formula: see text] blood sampled peripheral catheters, respectively....
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (E
Background Despite oxygen being the commonest drug administered to critically ill patients we do not know which saturation (SpO 2 ) target results in optimal survival outcomes those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial United Kingdom (UK) assess whether it would be possible host larger national multi-centre evaluate oxygenation targets mechanically ventilated patients. Methods set out recruit 60 participants across two sites into...
Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about competing harms both hyperoxia and hypoxia. Notwithstanding a Cochrane review concluding that routinely administering fractional inspired concentration (FiO
Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce rates improve outcomes from surgery. Previous small trials cardiac-output guided haemodynamic therapy algorithms have suggested this intervention results reduced complications modest reduction mortality. However, existing evidence is based mainly elective (planned) surgery, with little...
Whilst the management of Coronavirus disease-2019 (COVID-19) has evolved in response to emerging data, treating such patients remains a challenge, and many treatments lack robust clinical evidence. We conducted survey evaluate Intensive Care Unit (ICU) COVID-19 with acute hypoxic respiratory failure compared results data from similar focusing on Acute Respiratory Distress Syndrome (ARDS) that was 2013.The questionnaire refined previous ARDS-related practice using an online electronic engine...
Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part the Xtreme Alps study (a randomised placebo-controlled trial dietary nitrate supplementation under field conditions hypobaric hypoxia), we investigated whether with could improve NO availability microvascular flow in lowlanders. Plasma measurements nitrate, nitrite nitroso species were performed...
At high altitude, reduced atmospheric pressure causes the partial of oxygen to decreasecreating an environment hypobaric hypoxia which presents a unique set challenges for respiratory system.Pulmonary physiological responses such as hypoxic ventilatory drive are essential successful acclimatisation, whilst others pulmonary vasoconstriction may be implicated in development altitude illnesses.Pulmonary conditions some most common (e.g.high cough) and also serious illnesses seen at (e.g oedema,...
Nitrate supplementation in the form of beetroot juice (BRJ) ingestion has been shown to improve exercise tolerance during acute hypoxia, but its effect on physiology remains unstudied sustained terrestrial high altitude exposure. We hypothesized that performing at would lower circulating nitrate and nitrite levels BRJ reverse this phenomenon while concomitantly improving key determinants aerobic performance.Twenty seven healthy volunteers (21 male) underwent a series tests sea level (SL,...