A5103235832- Organ Transplantation Techniques and Outcomes
- Infrared Thermography in Medicine
- High Altitude and Hypoxia
- Cardiac Ischemia and Reperfusion
- Thermoregulation and physiological responses
- Anesthesia and Neurotoxicity Research
- thermodynamics and calorimetric analyses
- Lymphoma Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Chronic Lymphocytic Leukemia Research
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Obesity and Health Practices
- Craniofacial Disorders and Treatments
- Neuroscience of respiration and sleep
- Head and Neck Surgical Oncology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Breast Lesions and Carcinomas
- Cardiovascular and Diving-Related Complications
- Occupational Health and Performance
- Health and Lifestyle Studies
- melanin and skin pigmentation
- Machine Learning in Healthcare
Brooke Army Medical Center
2023
Wilford Hall Ambulatory Surgical Center
2023
University of Cambridge
2017-2022
Cambridge University Hospitals NHS Foundation Trust
2021-2022
University Hospital Southampton NHS Foundation Trust
2021
University College London
2009-2021
University of Southampton
2021
Duke University
2021
Royal London Hospital
2021
Addenbrooke's Hospital
2017-2019
Caucasian subjects from a temperate climate immersed their right index fingers in stirred ice-water bath for 20 min four times daily 1 month. During subsequent test immersion, exposed this way showed an earlier initiation and more rapid rate of spontaneous rewarming higher labile final temperature level than did either the same finger before prolonged cold exposure or other digits not chronically exposed. The inference derived these data that blood flow is elevated cold-exposed was supported...
Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The conditions designed to be protective however the artificial environment can induce local inflammatory response. aim of this study was determine effect incorporating Cytosorb adsorber into an isolated kidney system. Porcine kidneys were subjected 22 h cold ischaemia then reperfused for 6 on ex vivo reperfusion circuit. Pairs randomised either control (n = 5) or with integrated Tissue, blood...
Ex vivo perfusion (EVP) is a novel method of preservation. However, optimal conditions remain undetermined. Reducing the temperature perfusate to subnormothermia may be beneficial during EVP and improve early graft function. The aim this study was investigate whether would influence conditioning effect when compared with normothermic perfusion, standard cold static storage (CS).Porcine kidneys underwent CS for 23 hours followed by 1 hour using leukocyte-depleted blood at mean 32°C or 37°C....
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim this study was describe the relationship between physiological variables and incidence AMS during ascent 5300 m. A total 332 lowland-dwelling volunteers followed an identical profile on staggered treks. Self-reported symptoms were recorded daily using Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO
Kidney normothermic machine perfusion (NMP) has historically used a 95% O2-5% CO2 gas mixture. Using porcine model of organ retrieval, NMP, and reperfusion, we tested the hypothesis that reducing perfusate oxygenation ( PpO2 ) would be detrimental to renal function cause injury. In minimal ischemic injury experiment, kidneys sustained 10 min warm ischemia 2 h static cold storage before 1 NMP with either 95%, 25%, or 12% O2 5% N2 balance. clinical 10-min 17-h underwent 1-h above combinations...
A method is described to quantify regional blood flow by thermal analysis. weak temperature field established in a tissue and for steady state, unidirectional heat flux the associated gradient are measured simultaneously across small fixed segment of tissue. This information evaluated with probe calibrations homogeneous isotropic fluids, data from ancillary measurements nonperfused values specific density express local transfer [effective conductivity (W. degrees C-1 . cm-1 x 10(-3) and/or...
Classic teaching suggests that diminished availability of oxygen leads to increased tissue extraction yet evidence support this notion in the context hypoxaemia, as opposed anaemia or cardiac failure, is limited.At 75 m above sea level, and after 7-8 days acclimatization 4559 m, systemic [C(a-v)O2] was calculated five participants at rest peak exercise. Absolute by subtracting central venous content (CcvO2) from arterial [Formula: see text] blood sampled peripheral catheters, respectively....
Oxygen availability falls with ascent to altitude and also as a consequence of critical illness. Because cellular sequelae adaptive processes may be shared in both circumstances, high exposure ('physiological hypoxia') assists the exploration response pathological hypoxia. We therefore studied healthy participants progressive hypobaric hypoxia at altitude. The primary objective study was identify differences between inhabitants (Sherpas) lowland comparators.We performed an observational...
Abstract In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term survival. Hydrogen has antioxidant anti‐inflammatory properties that the effects of ischemic injury. The aim this study was to examine hydrogen gas administered during in a preclinical model kidney Porcine kidneys underwent 15 min warm followed by 22 h cold ischemia. They were then reperfused for 6 with whole autologous blood on an ex vivo circuit. Paired randomized control (...
To quantify parietal bone motion in reference to the medial sagittal suture, a newly developed instrument was attached surgically exposed skull of anesthetized adult cats.The dif- ferentiated between lateral and rotational movements around fulcrum suture.Bone movement produced by external forces applied changes intracranial pressure associated with induced hypercapnia, intravenous injections norepinephrine, controlled artificial cerebrospinal fluid into cerebral ventricle.Responses varied...
In 2003, Arkansas became the first state to require body mass index (BMI) testing in public schools raise awareness of growing obesity epidemic among children and adolescents. Limited information exists regarding effectiveness school-based BMI screening programs. The purpose this study was determine if health report cards affected parents' knowledge or actions their child's accuracy perceptions child as underweight, normal weight, overweight according BMI. A questionnaire developed with help...