A5008278799- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- High Altitude and Hypoxia
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Organ Transplantation Techniques and Outcomes
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Drug-Induced Adverse Reactions
- Global Health and Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Travel-related health issues
- Cardiovascular Issues in Pregnancy
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Cardiac Structural Anomalies and Repair
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Anesthesia and Pain Management
King's College Hospital
2010-2024
King's College Hospital NHS Foundation Trust
2010-2024
Association of Anaesthetists of Great Britain and Ireland
2020
King's College London
2020
St Michael's Hospital
2018
University College London
2005-2017
University College London Hospitals NHS Foundation Trust
2017
National Institute for Health Research
2017
Centro de Investigación Biomédica en Red
2017
Hospital Universitario de Getafe
2017
Why was this consensus statement developed? Advances in clinical practice are sometimes inhibited by a multitude of different options that need to be selected. There has been significant variation the treatment spinal anaesthesia-induced hypotension. These guidelines designed provide clinicians with specific best-practice plans will cover wide range drug and equipment availability. Detailed recommendations provided for management hypotension resource-rich resource-poor environments. How does...
Significance A relative fall in tissue oxygen levels (hypoxia) is a common feature of many human diseases, including heart failure, lung anemia, and cancers, can compromise normal cellular function. Hypoxia also occurs healthy humans at high altitude due to low barometric pressures. Human populations resident the Himalayas have evolved mechanisms that allow them survive perform, adaptations preserve delivery tissues. Here, we studied one such population, Sherpas, found metabolic adaptations,...
Despite the acknowledged injustice and widespread existence of parachute research studies conducted in low- or middle-income countries by researchers from institutions high-income countries, there is currently no pragmatic guidance for how academic journals should evaluate manuscript submissions challenge this practice. We assembled a multidisciplinary group editors with expertise international health to develop consensus statement. reviewed relevant existing literature held three workshops...
Sevoflurane sample data in a standard single patient ICU room, VieCuri Medical Centre. Physical of the room: 52 m3, air refreshing rate minimum 6/hr
Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting lower arterial oxygen content than acclimatized lowlanders. This study tested the hypothesis Sherpas exposed hypobaric on ascent 5,300 m develop increased microcirculatory blood flow as a means of maintaining tissue delivery. Incident dark-field imaging was used obtain images sublingual microcirculation from 64 and 69 Serial measurements were obtained...
We hypothesized that ascent to altitude would result in reduced sublingual microcirculatory flow index (MFI) and increased vessel density. Twenty-four subjects were studied using sidestream dark-field imaging, as they ascended 5300 m; one cohort remained at this (n = 10), while another higher (maximum 8848 n 14). The MFI, density grid crossings (GX; an alternative measure) calculated. Total study length was 71 days; images recorded sea level (SL), Namche Bazaar (3500 m), Everest base camp...
Summary The impact of hypoxaemia on blood coagulation remains unclear despite use a variety measures to address the issue. We report first thromboelastography (TEG) at high altitude describe dynamics clot formation in whole samples. Seventeen healthy volunteers ascended 5,300 m following an identical ascent profile; TEG measurements 4,250 and were compared with those from sea level. Peripheral oxygen saturation (SpO2) haematocrit also measured. Ascent resulted decline SpO2 97.8 (± 1.2) %...
Summary Sickle cell disease is a multisystem characterised by chronic haemolytic anaemia, painful vaso‐occlusive crises and acute end‐organ damage. It one of the most common serious inherited single gene conditions worldwide has major impact on health affected individuals. Peri‐operative complications are higher in patients with sickle compared general population may be or non‐sickle‐related. Complications reduced meticulous peri‐operative care transfusion, but unnecessary transfusion should...
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim this study was describe the relationship between physiological variables and incidence AMS during ascent 5300 m. A total 332 lowland-dwelling volunteers followed an identical profile on staggered treks. Self-reported symptoms were recorded daily using Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO
( Anaesthesia . 2018;73:71–92) The objective of this comprehensive consensus statement was to provide practical and independent advice physicians for treating managing spinal anesthesia-induced maternal hypotension in both resource-rich resource-poor environments. This clinical best practices summary necessary as there has been much variation the methods used manage during cesarean section, increases risks fetal/neonatal health. While generalized recommendations have made management problem...
Extracorporeal membrane oxygenation (ECMO) is increasingly used for the treatment of refractory but potentially reversible respiratory and/or cardiac failure. Data on perioperative support with veno-arterial (V-A) and veno-venous (V-V) ECMO adult liver transplant recipients are scarce [1,2].We report our experience in patients acute failure (ALF) as a bridge to postoperative use following complications after surgery.