A5101582445- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Bone Tumor Diagnosis and Treatments
- Voice and Speech Disorders
- Oral and Maxillofacial Pathology
- Dysphagia Assessment and Management
- Adipose Tissue and Metabolism
- Vascular Anomalies and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Prostate Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Head and Neck Cancer Studies
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Screening and Detection
- Airway Management and Intubation Techniques
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- Lipid Membrane Structure and Behavior
- Sarcoma Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Esophageal and GI Pathology
- Meningioma and schwannoma management
- Head and Neck Anomalies
- High Altitude and Hypoxia
Swansea University
2016-2025
Amgen (United Kingdom)
2023
University College London
1991-2022
Royal London Hospital
2022
Royal National Throat Nose and Ear Hospital
1994-2020
Gray's Inn
1983-2018
Charing Cross Hospital
2006-2017
University College London Hospitals NHS Foundation Trust
2006-2017
National Institute for Health Research
2017
Eastern Virginia Medical School
2017
In the treatment of lung cancer, best outcome is achieved when lesion discovered in intraepithelial (preinvasive) stage. However, neoplastic lesions are difficult to localize by conventional white-light bronchoscopy (WLB).To determine if autofluorescence bronchoscopy, used as an adjunct WLB, could improve bronchoscopist's ability locate and remove biopsy specimens from areas suspicious neoplasia compared with WLB alone.A multicenter clinical trial was conducted seven institutions United...
Significance A relative fall in tissue oxygen levels (hypoxia) is a common feature of many human diseases, including heart failure, lung anemia, and cancers, can compromise normal cellular function. Hypoxia also occurs healthy humans at high altitude due to low barometric pressures. Human populations resident the Himalayas have evolved mechanisms that allow them survive perform, adaptations preserve delivery tissues. Here, we studied one such population, Sherpas, found metabolic adaptations,...
Seventy-two patients with juvenile angiofibroma have been investigated by computerized tomography (CT) and/or magnetic resonance imaging (MRI) over a period of 20 years. The evidence from these studies indicates that takes origin in the pterygo-palatine fossa at aperture pterygoid (vidian) canal. An important extension tumour is posteriorly along canal invasion cancellous bone base, and greater wing sphenoid (60 per cent patients). Distinctive features are high recurrence rate, rapidity...
To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection.A single-center prospective cohort study.All treated a 23-year period resection (with or without radiotherapy) were analyzed; multivariate analysis was included.Forty-two aged 12 to 70 years assessed, 83% of whom had received no preceding treatment. Craniofacial used all cases, combined radiotherapy 24 (57%). Duration follow-up ranged from 2 206 months (mean period, 57...
The rarity of sinonasal tumors has precluded long-term follow-up large series craniofacial resections until now.A 209 patients suffering from a wide range histologies who had undergone resection for neoplasia with up to 17 years' were analyzed.An overall actuarial survival 51% at 5 years and 41% 10 was found the cohort as whole. For malignant tumors, 5-year 44%, falling 32% years. benign pathology, 75% both Statistical analysis identified three factors which significantly affect outcome...
Craniofacial resection is the established "gold standard" for surgical treatment of tumors affecting anterior skull base.This study analyzed 308 patients (220 males, 88 females) who had undergone craniofacial sinonasal neoplasia with up to 25-year follow-up.An overall actuarial survival 65% at 5 years and 47% 10 was found cohort as a whole. For malignant tumors, 5-year 59%, falling 40% years. benign pathology, 92% 82% Statistical analysis again identified brain involvement, type malignancy,...
Objectives/Hypothesis To validate a follow‐up protocol based on the long‐term outcomes and recurrence rates in patients who have undergone surgical treatment for olfactory neuroblastoma. Methods A prospective review of all treated neuroblastoma at our institution over 35‐year period. Results Ninety‐five were from 1978 to 2013, with craniofacial (65 patients) or endoscopic resection (30 patients). Duration ranged 1 309 months (mean, 88.66 months). Fifty‐six alive well, 13 recurrent disease....
Abstract Objective Angiofibroma is a highly vascular lesion for which wide range of surgical approaches has been recommended. Irrespective the approach, significant and often rapid recurrence rate reported in all major series. Aim To consider impact lessons learned from imaging on angiofibroma. Material Methods From cohort 90 male patients with histologically proven angiofibroma, 40 individuals were studied. The 20 cases treated before March 1998 was compared that 19 thereafter. In latter...
Type 1 diabetes is known to be a state of insulin resistance; however, the tissues involved in whole-body resistance are less well known. It unclear whether due glucose toxicity post-Diabetes Control and Complications Trial era tighter control.We performed this study determine muscle liver sensitivity individuals with type after overnight infusion lower fasting concentration.Fifty subjects [25 controls without 25 (diabetes duration 22.9 ± 1.7 yr, end organ damage] were frequency matched on...
Abstract Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding its clinical presentation, course, optimal limited, few advancements in improving management have been made recent past. Methods We conducted international multicenter retrospective analysis 505 SNMM cases from 11...
Epithelial ovarian cancer (EOC) is an aggressive and lethal gynaecologic malignancy due to late diagnosis acquired resistance chemotherapeutic drugs, such as cisplatin. EOC metastasis commonly occurs through the extensive dissemination of multicellular aggregates, formed cells originally shed from primary tumour, within peritoneal cavity. However, little known about how cisplatin (CR) alters biophysical properties aggregates this impacts metastasis. In interdisciplinary study, light atomic...
From a cohort of 35 patients with hereditary haemorrhagic telangiectasia (HHT), 12 have undergone closure the one or both nasal cavities during last three years for refractory epistaxis. All had failed other forms treatment including hormone therapy, laser coagulation and septodermoplasty. were available follow-up at six months longer. In all where complete was achieved (11 out 12) bleeding ceased completely from operated side.
Fifty patients with a wide range of sinus disease have been examined by magnetic resonance. These included congenital conditions, inflammatory and allergic disease, fungus infection, both necrotising non-necrotising granulomas. A variety benign malignant tumours investigated, including eight examples juvenile angiofibroma 19 tumours. This experience resonance scanning has shown that it is superior to computed tomography in showing the extent and, provided correct pulse sequences are...
To assess the results of primary endoscopic treatment adult postintubation tracheal stenosis, to identify predictors a successful outcome, and better define scope limitations minimally-invasive surgery for this condition.Sixty-two consecutive patients treated between April 2003 2006 with initial were prospectively studied. Patient lesion characteristics, details, complications, decannulation, open rates recorded. Actuarial analysis Cox regression used decannulation freedom from external...
Histological classification of laryngeal epithelial lesions is highly subjective, and methods cytological detection are not well developed. Improved determination aberrant cell cycle entry may allow increased objectivity in histological assessment enable the development less invasive diagnostic cytology tests. Sections normal larynx (n=10), dysplasia (n=20) squamous carcinoma (SCC) (n=10) were classified according to Ljubljana stained for markers entry, minichromosome maintenance protein-2...
To report on the management of laryngoceles by CO2 laser-assisted endoscopic excision.A 15-year retrospective study 12 adult patients (7 men and 5 women) who presented with a laryngocele. Nine had an internal laryngocele, one patient external two combined internal-external components. Two were right-sided, six left-sided, four bilateral.An examination laryngocele was carried out for both diagnostic therapeutic purposes. Once identified air- or mucus-filled cyst (extending from laryngeal...
We examined the management options used for epistaxis of varying severity in patients with hereditary hemorrhagic telangiectasia (HHT) to develop a treatment algorithm. Fifty HHT were studied from 1991 1997 consider various and their relative efficacy. There 28 females 22 men; ages ranged 15 85. Follow-up 6 months years. A wide variety treatments had been (including forms cautery, septal surgery, topical systemic hormones, antifibrinolytic therapy, arterial ligation, laser closure nostrils)....
Type 1 diabetes is an insulin-resistant state, but it less clear which tissues are affected. Our previous report implicated skeletal muscle and liver insulin resistance in people with type diabetes, this occurred independently of generalized, visceral, or ectopic fat. The aim the study was to measure adipose tissue sensitivity plasma triglyceride composition individuals after overnight infusion lower fasting glucose. Fifty subjects (25 25 controls without) were studied. After 3 d dietary...
Background Epistaxis is the most common symptom in patients with hereditary hemorrhagic telangiectasia. Different treatment options have been described but little reference to their effect on quality of life or disease severity. Methods This study prospectively investigated nasal closure, argon laser, and a combination septodermoplasty laser treatments quality-of-life scores severity ratings group 29 moderate severe epistaxis referred tertiary referral center. Results The only who showed...
Computerized tomography (CT) has been shown to be 78% accurate with respect anatomic extent of tumor when correlated operative findings and histology in patients undergoing craniofacial resection. To determine whether preoperative evaluation could improved by the combination CT magnetic resonance imaging (MRI), 26 paranasal sinuses had undergone MRI before surgery addition CT. Ten also received Gadolinium-DTPA as a contrast-enhancement agent during MRI. The radical approach offered resection...