A5054500447- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Tracheal and airway disorders
- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Airway Management and Intubation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Tumors and Oncological Cases
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Nasal Surgery and Airway Studies
- Dysphagia Assessment and Management
- Allergic Rhinitis and Sensitization
- Ear and Head Tumors
- Cardiac Arrest and Resuscitation
Johns Hopkins University
2020-2025
Johns Hopkins Medicine
2021-2025
National Patient Safety Foundation
2023
Pioneer (United States)
2023
Stanford University
2017-2021
Center for Rheumatology
2021
University of Chicago
2019
Duke Medical Center
2013-2017
Duke University
2016-2017
Duke University Hospital
2013-2017
US hospitals report data on many health care quality metrics to government and independent rating organizations, but the annual cost acute of measuring reporting metric data, resources spent interventions, is not well known.To evaluate externally reported inpatient for adult patients estimate collection reporting, quality-improvement efforts.Retrospective time-driven activity-based costing study at Johns Hopkins Hospital (Baltimore, Maryland) with hospital personnel involved in processes...
Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV as tumor-specific immunotherapy targets. A recent trial recurrent patients demonstrated the potential clinical benefit of adoptive T-cell therapy (ATCT) phosphoprotein 65 (pp65)-specific T cells. However, ex vivo analyses from this study found no change capacity pp65-specific cells gain multiple...
Leydig cells are the steroidogenic lineage of mammalian testis that produces testosterone, a key hormone required throughout male fetal and adult life for virilization spermatogenesis. Both arise from progenitor population in interstitium but thought to be lineage-independent one another. Genetic evidence indicates Notch signaling is during maintain balance between differentiated their progenitors, elusive cell type ligands involved have not been identified. In this study, we show pathway...
Objectives Despite the epidemic of opioid overuse among American patients, there are limited data regarding prevalence such use patients with head and neck cancer (HNC). Here, we report on persistent postoperative (PPO) its risk factors older HNC undergoing surgery. Study Design Retrospective cohort study. Setting Surveillance, Epidemiology, End Results (SEER)–Medicare linked registry‐claims database. Subjects Methods We identified aged 66 years or who were diagnosed from 2008 to 2013,...
Abstract Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding its clinical presentation, course, optimal limited, few advancements in improving management have been made recent past. Methods We conducted international multicenter retrospective analysis 505 SNMM cases from 11...
Olfactory dysfunction is highly associated with chronic rhinosinusitis nasal polyps (CRSwNP), and the severity of loss has been linked biomarkers type 2 inflammation. The ability dupilumab to rapidly improve sense smell prior improvement in polyp size suggests a direct role IL-4/IL-13 receptor signaling olfactory epithelium (OE).
Abstract The use of genomic testing for patients with anterior skull base malignancies has grown dramatically. There are no clear guidelines on indications testing. As the literature subject is still in early stages, there a need expert consensus. We conducted modified Delphi consensus process high-volume North American cranial surgical programs. A approach was used, following method laid out by Academy Otolaryngology-Head and Neck Surgery, included 13 care centers. An otolaryngologist...
Kanu Okike, MD, MPH; Priscilla H. Chan, MS; Ronald A. Navarro, MD; Monti X. Khatod, Elizabeth W. Paxton, PhD; Heather Prentice, PhD
This Viewpoint addresses the lack of reimbursement for olfactory testing, which is especially important in a time when populations older adults and patients with COVID-19–associated dysfunction have grown.
To evaluate the impact of insurance status on survival among patients with major salivary gland cancer.Retrospective cohort study.SEER program.We included aged <65 years diagnosed cancers from 2007 to 2013. Those ≥65 were excluded due issues ascertaining status. The independent variable was (insured, uninsured, or Medicaid); primary outcome measure overall (OS); and secondary disease-specific (DSS).Compared insured patients, uninsured Medicaid more likely present stage III-IV disease...
There is an increasing array of treatment options for addressing clinically significant thyroid nodules, including radiofrequency ablation (RFA). While effective, the cost compared to alternative approaches has not been well elucidated.This study involved a retrospective chart review, focusing on variable direct (VDC) each procedure, from April 2016 January 2020. We analyzed costs 53 open lobectomies and 16 RFA procedures.Cost effectiveness depended simulated probe. In comparison lobectomy,...
Background: Acute mountain sickness (AMS) is a common disease that may have pulmonary component, as suggested by interstitial edema quantified the B-line score (BLS) on ultrasound (US). This subclinical has been shown to increase with ascent high altitude and AMS severity, but not prospectively associated incidence in large prospective study. Materials Methods: observational study was part of randomized controlled trial enrolling healthy adults over four weekends ascending White Mountain,...
<b><i>Background:</i></b> Greater than 100,000 tracheotomies are performed annually in the USA, yet little is known regarding patients who present to emergency department (ED) with tracheostomy complications. <b><i>Objectives:</i></b> To characterize patient and hospital characteristics, outcomes, charges associated complications identify predictors of admission mortality. <b><i>Methods:</i></b> The 2009–2011 Nationwide...
Objective Most patients with nasopharyngeal carcinoma (NPC) in the United States are diagnosed stage III‐IV disease. Screening for NPC endemic areas results earlier detection and improved outcomes. We examined cost‐effectiveness of screening plasma Epstein‐Barr virus DNA among Asian American men States. Study Design used a Markov cohort model to estimate discounted life‐years, quality‐adjusted life‐years (QALYs), costs, incremental ratios as compared usual care without screening. Setting The...
Abstract Objective Fistula remains a common complication of upper aerodigestive tract reconstruction. Optimal timing oral feeding is unknown and the impact early on swallow function fistula rates controversial. The purpose this study to better understand effects “early feeding” rate in patients with free flap reconstruction defects. Methods Retrospective cohort study. One hundred four undergoing mucosalized head neck Two groups, (oral intake or before postoperative day 5) late‐feeding after...
The ongoing COVID-19 pandemic has profoundly impacted the provision of surgical care.1, 2 We have previously reported that outpatient and inpatient otolaryngology volume dropped over 80% 40%, respectively, at onset pandemic.3 sought to describe pandemic's impact on subspecialty case in comparison other specialties. queried specialty from Vizient Clinical Data Base™ (CDB) (Vizient, Inc. Irving, TX) January 1, 2019, March 31, 2021 (Supplementary Methods online version this article). A...
Objective Difficult intubations are not uncommon in tertiary care children's hospitals, and effective documentation of the difficult airway is a fundamental element safe management. The primary goal our quality improvement initiative was to improve access information via an alert system within electronic medical record (EMR). Methods We created EMR, linking common evaluation templates used by specialists involved assessed time required for different answer questionnaire using charts patients...
Clinicians frequently use radiotherapy with cetuximab over only or cisplatin because of a perceived survival and tolerability advantage, but scant data are available to support this perception.To measure the 3 aspects value (quality, outcomes, cost) in older patients receiving only, cisplatin, for locoregionally advanced head neck cancer.For cohort study, patient records were obtained from Surveillance, Epidemiology, End Results Program (SEER)-Medicare outcomes claims database January 1,...