A5023733982- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Microtubule and mitosis dynamics
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Viral-associated cancers and disorders
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
Stanford Medicine
2024
Stanford University
2015-2023
University of Michigan
2011-2023
Pfizer (United States)
2023
Stanford Cancer Institute
2015-2018
VA Palo Alto Health Care System
2017-2018
Swedish American Hospital
2017
Stanford Health Care
2017
The University of Texas MD Anderson Cancer Center
2017
Cancer Institute (WIA)
2017
This article highlights trends and changes in lung heart–lung transplantation the United States from 1999 to 2008. While adult grew significantly over past decade, rates of pediatric have remained low. Since implementation allocation score (LAS) donor system 2005, decreases number active waiting list patients, times for death on occurred. However, characteristics recipients transplanted LAS era differed those earlier. The proportion candidates undergoing chronic obstructive pulmonary disease...
Purpose The Clinical Evaluation of Pertuzumab and Trastuzumab (CLEOPATRA) study showed a 15.7-month survival benefit with the addition pertuzumab to docetaxel trastuzumab (THP) as first-line treatment for patients human epidermal growth factor receptor 2 (HER2) –overexpressing metastatic breast cancer. We performed cost-effectiveness analysis assess value adding pertuzumab. Patient Methods developed decision-analytic Markov model evaluate cost effectiveness plus (TH) or without in US...
Abstract Purpose: The combination of radiation with chemotherapy is the most effective therapy for unresectable pancreatic cancer. To improve upon this regimen, we combined selective Checkpoint kinase 1 (Chk1) inhibitor MK8776 gemcitabine-based chemoradiation in preclinical cancer models. Experimental Design: We tested ability to sensitize gemcitabine-radiation homologous recombination repair (HRR)–proficient and –deficient cells assessed Rad51 focus formation. In vivo, investigated...
Chk1 inhibitors, such as AZD7762, are in clinical development combination with cytotoxic agents for the treatment of solid tumors, including pancreatic cancers. To maximize likelihood their success, it is essential to optimize drug scheduling well pharmacodynamic biomarkers preclinical models.We tested multiple schedules administration gemcitabine and AZD7762 on survival cancer cells. Potential pChk1, pChk2, pHistone H3, caspase-3 were evaluated vitro, followed by assessment promising...
The goal of this study was to develop and assess the effectiveness an affordable smartphone-based virtual reality (VR) patient education platform with 360-degree videos produced depicting a first-person perspective during radiation therapy (RT) care path reduce anxiety.Three disease site-specific (breast, pelvis, head neck) VR were filmed using camera portray patient's standard RT appointments, including computed tomography simulation first treatment session. Instruction is given for...
Neoadjuvant chemotherapy (NAC) is used to allow more limited breast surgery without compromising local control. We sought evaluate nationwide surgical trends in patients with operable cancer treated NAC and factors associated type. the National Cancer Database identify 235,339 women unilateral T1-3 N0-3 M0 diagnosed between 2010 2014 chemotherapy. Of these, 59,568 (25.3%) were NAC. Rates of pathological complete response (pCR) increased from 33.3% at start study period 46.3% end (p = 0.02)....
1024 Background: Treatment with bisphosphonates in pts metastatic breast cancer prevents osteoclast-mediated skeletal related events (SREs) and reduces pain. Denosumab, an investigative fully human monoclonal antibody against RANKL, was superior to ZA delaying preventing SREs a recently completed randomized trial of bone metastases. Here, we describe pain outcomes from this study. Methods: Eligible received either subcutaneous denosumab 120 mg or intravenous 4 every weeks double-bind,...
The addition of procarbazine, lomustine, vincristine (PCV) chemotherapy to radiotherapy (RT) for patients with high-risk (≥40 y old or subtotally resected) low-grade glioma (LGG) results in an absolute median survival benefit over 5 years. We evaluated the cost-effectiveness this treatment strategy.A decision tree integrated 3-state Markov model was created follow LGG after surgery treated RT versus RT+PCV. Patients existed one 3 health states: stable, progressive, dead. Survival and freedom...
Objective Most patients with nasopharyngeal carcinoma (NPC) in the United States are diagnosed stage III‐IV disease. Screening for NPC endemic areas results earlier detection and improved outcomes. We examined cost‐effectiveness of screening plasma Epstein‐Barr virus DNA among Asian American men States. Study Design used a Markov cohort model to estimate discounted life‐years, quality‐adjusted life‐years (QALYs), costs, incremental ratios as compared usual care without screening. Setting The...
Purpose The integration of 3D-printing technology into radiation therapy (RT) has allowed for a novel method to develop personalized electron field-shaping blocks with improved accuracy. By obviating the need handling highly toxic Cerrobend molds, clinical workflow is significantly streamlined. This study aims expound upon 3D-printed cutouts in RT and furnish one year in-vivo dosimetry data. Methods materials 6x6 cm, 10x10 15x15 cm applicators were designed implemented after dosimetric...
577 Background: Trimodality bladder preservation is an acceptable alternative to radical cystectomy (RC) for muscle invasive cancer (MIBC). Multiple retrospective studies have reported similar disease control rates and overall survival with chemoradiation (CRT), but the benefit of neoadjuvant chemotherapy (NAC) prior CRT not established. This study investigates outcomes or without NAC management MIBC. Methods: Retrospective analysis 135 adult patients evaluated in Department Radiation...
Drivers of variation in the cost care after chemoradiotherapy for management anal squamous cell carcinoma (SCC) have not been fully elucidated. We sought to characterize direct and indirect impact radiotherapy modality on health costs among patients with SCC.
We present the case of a 42-year-old woman with metastatic synovial sarcoma parotid origin, treated definitively chemoradiation, who subsequently developed oligometastatic disease limited to lungs. She underwent multiple left and right lung wedge resections lower lobectomy, followed by lobe stereotactic ablative radiotherapy (SABR), 54 Gy in three fractions lesion abutting chest wall. Two years later, she was cryoablation for separate upper nodule months presented acute shortness breath,...
201 Background: Various schedules of palliative radiotherapy (pRT) are prescribed for metastatic breast cancer (MBC) patients. Length treatment can vary from a single day to three weeks. Single fraction pRT provides similar pain relief vs. multi-fraction bone metastases, but retreatment rates higher. In the era targeted and hormonal therapy, patients with MBC survive many years after their initial diagnosis. We investigated whether who were had poorer prognoses experienced shorter survival...