The median survival for patients with locally advanced pancreatic cancer treated gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, ionizing preclinical tumor models. We found that vitro AZD7762 alone or combination significantly sensitized MiaPaCa-2 cells to radiation. inhibited Chk1 autophosphorylation (S296 Chk1), stabilized Cdc25A, increased ATR/ATM-mediated...

Chk1 inhibitors, such as AZD7762, are in clinical development combination with cytotoxic agents for the treatment of solid tumors, including pancreatic cancers. To maximize likelihood their success, it is essential to optimize drug scheduling well pharmacodynamic biomarkers preclinical models.We tested multiple schedules administration gemcitabine and AZD7762 on survival cancer cells. Potential pChk1, pChk2, pHistone H3, caspase-3 were evaluated vitro, followed by assessment promising...

Guidelines from the National Cancer Institute Thyroid Fine Needle Aspiration State of Science Conference recommend a repeat fine-needle aspiration biopsy (FNAB) after 3 months for thyroid nodules with nondiagnostic (ND) result. Our aims were to assess which factors influenced their clinical management and determine if timing FNAB affects diagnostic yield.A retrospective institutional review 298 patients 1/2006 12/2007 an ND was performed. The influencing next step in management, including...

We aimed to study the role of ultrasound in diagnosis chronic kidney disease (CKD) and its correlation with serum creatinine level.This was a retrospective cross sectional conducted department Dr. Ziauddin Hospital Clifton campus, Karachi from April 6, 2017 October for period six months. A total 200 patients CKD glomerular filtration rate (GFR) determined be < 60 ml/min were included this study. Blood tests gathered chosen patients, estimation done those they underwent ultrasonography on...

The current research investigated the conversion of banana stem waste into cellulose nitrate, a potential bioplastic precursor. is prime importance in terms environmental pollution and sustainable development goals. study aimed to isolate from stems, synthesize nitrocellulose, assess its stability. Two different methods, that is, Method A, comprising HNO3 H2SO4, B, P2O5, were applied each using acidic mixtures. A resulted high nitrocellulose yield higher nitrogen content but lower content....

Clinical evidence suggests that gemcitabine (Gem) plus oxaliplatin (Ox) is superior to alone in advanced pancreatic carcinoma. The addition of radiation improves response and a standard treatment for locally disease. We investigated the effect on gemcitabine-based chemoradiation by determining whether produced synergistic cytotoxicity using median analysis radiosensitization clonogenic survival assays. analyzed effects cell cycle distribution DNA content radiation-induced damage repair...

Objective To determine the diagnostic accuracy of multidetector computed tomography (MDCT) in detection esophageal varices by taking endoscopy as reference standard. Materials and methods This was a cross-sectional prospective study conducted at Department Radiology, Aga Khan University Hospital, (AKUH) Karachi, for duration 12 months from August 1, 2014 to July 31, 2015. One hundred ninety-six patients with suspicion chronic liver disease/cirrhosis undergoing 64 slice MDCT were enrolled our...

Integrating game elements into gaming-related applications has long been recognized as a powerful tool for enhancing user engagement and overall effectiveness. Despite the numerous studies examining impact of gamification on engagement, specific factors that drive this phenomenon remain unclear. To address knowledge gap, present study employs gameful experience questionnaire (GAMEFULQUEST) perspective in context fitness apps, exploring effects seven key gamified consumer engagement. The...

Objective To determine the role of multidetector computed tomography (MDCT) with multiplanar (MPR) and curved reformations (CMPR) in detection cause intestinal obstruction. Materials methods A retrospective analysis 200 patients a clinical suspicion obstruction referred to department radiology, Dr. Ziauddin University Hospital, Clifton campus, from September 2016 October 2019, was done. All who underwent an MDCT scan oral intravenous (I/V) contrast were included study. Patients deranged...

Objective To determine the diagnostic accuracy of echo-planar diffusion-weighted imaging (DWI) in diagnosis intra-cerebral abscesses by taking histopathological findings as gold standard. Subject and methods A retrospective cross-sectional study was performed from July 2014 to June 2015 at a tertiary care hospital Karachi. total 462 patients, who were referred for magnetic resonance (MRI) brain, presenting with clinical suspicion an abscess on basis signs symptoms, included this study. MR...

This research intended to measure the overall emotional intelligence level based on Bar model in terms of intrapersonal, interpersonal, stress management, general mood and adaptability compare results for males females. It also examined relationship between two cognitive abilities –decision making management. For this very purpose, students NUST, College Electrical Mechanical Engineering, Rawalpindi, age limit 17 25 years were asked fill out a questionnaire quotient (EQ). The validated from...

Iron chelation treatments as adjuvant therapy can reduce iron stores to minimize the related morbidity and mortality in patients with thalassemia major. Objective: To compare Deferasirox (DFX) Desferrioxamine (DFO) terms of mean serum ferritin levels β-thalassemia major having overload. Methods: This randomized controlled trial was conducted at Thalassemia Center Hematology Department, “The Children's Hospital The Institute Child Health”, Multan, Pakistan from January 2023 September 2023....

Drawing on social exchange theory, this article examines how consumers’ engagement with gamified branded mobile apps impacts different aspects of their gameful experience, which comprises accomplishment, competition, challenge, immersion, guidance, playful and experience. We test the proposed conceptual model by drawing data collected from 319 adult app users emerging market Pakistan, was analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The findings reveal that in...

Vasitis nodosa involves benign, reactive spindle-shaped nodular thickening of the ductal epithelium vas deferens. We report case a 21-year-old male with history bilateral undescended testes and left orchidopexy. The patient presented complaint non-tender inguinal swelling. definitive diagnosis vasitis was made based on clinical evaluation imaging findings. suggest that this rare entity should be considered as differential swelling during assessment urogenital system.

&lt;p&gt;Background and objective: Birth asphyxia is a common pathological condition seen in newborns with increased morbidity mortality. Grave consequences following birth require earlier recognition of the precipitating factors prompt treatment intensive care units. Multiple electrolyte imbalance has been related to this condition. This study aimed at determining mean serum total calcium levels neonates asphyxia.&lt;/p&gt;&#x0D; &lt;p&gt;Methods: cross sectional was performed neonatal unit...

Objective We conducted this study to determine the added value of curved multiplanar reformations (CMPR) and (MPR) multidetector computed tomography (MDCT) scan in visualization localization zone transition patients with intestinal obstruction. Materials methods A total 100 suspected bowel obstruction were evaluated a retrospective cross-sectional from September 2016 2018 at Dr. Ziauddin University Hospital, Clifton Campus. All underwent (CT) scans oral intravenous contrast before surgical...

Chest wall hematoma commonly occurs as a result of blunt thoracic trauma. We report an intriguing case spontaneous lateral chest that presented with right scapular swelling and tenderness on palpation having hemodynamic instability without any prior history recent trauma or surgery. x-ray ultrasound were carried out at the time admission to evaluate swelling, followed by contrast-enhanced CT (CECT) identify localize bleeder. Transcatheter arterial embolization (TAE) intercostal artery was...

Supplementary Figures 1-3, Tables 1-3 from Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation G&lt;sub&gt;2&lt;/sub&gt; Checkpoint and Inhibition Homologous Recombinational DNA Repair

Supplementary Figures 1-3, Tables 1-3 from Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation G&lt;sub&gt;2&lt;/sub&gt; Checkpoint and Inhibition Homologous Recombinational DNA Repair

&lt;div&gt;Abstract&lt;p&gt;The median survival for patients with locally advanced pancreatic cancer treated gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, ionizing preclinical tumor models. We found that &lt;i&gt;in vitro&lt;/i&gt; AZD7762 alone or combination significantly sensitized MiaPaCa-2 cells to radiation. inhibited Chk1 autophosphorylation (S296 Chk1),...

&lt;div&gt;Abstract&lt;p&gt;The median survival for patients with locally advanced pancreatic cancer treated gemcitabine and radiation is approximately 1 year. To develop improved treatment, we have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, ionizing preclinical tumor models. We found that &lt;i&gt;in vitro&lt;/i&gt; AZD7762 alone or combination significantly sensitized MiaPaCa-2 cells to radiation. inhibited Chk1 autophosphorylation (S296 Chk1),...