A5073413446- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Sinusitis and nasal conditions
- Bone Tumor Diagnosis and Treatments
- Meningioma and schwannoma management
- Tracheal and airway disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Infectious Diseases and Mycology
- Voice and Speech Disorders
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Pituitary Gland Disorders and Treatments
- Facial Nerve Paralysis Treatment and Research
- Tumors and Oncological Cases
- Vestibular and auditory disorders
- Neurofibromatosis and Schwannoma Cases
- Otolaryngology and Infectious Diseases
- Hearing Loss and Rehabilitation
- Sarcoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Phonetics and Phonology Research
Centro de Investigación Biomédica en Red de Cáncer
2017-2024
Universidad de Oviedo
2013-2024
Central University Hospital of Asturias
2015-2024
Kennedy Clinic Hospital
2024
Instituto de Salud Carlos III
2021-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2014-2023
Centro de Investigación Biomédica en Red
2020
Complejo Hospitalario Torrecárdenas
2004-2019
Roche (Spain)
2019
Radboud University Medical Center
2018
The aim of this prospective observational study was to determine those factors influencing bacterial colonization in patients with stable chronic obstructive pulmonary disease (COPD). Eighty-eight outpatients COPD and 20 normal spirometry chest radiography (controls) had a fibreoptic bronchoscopy performed topical aerosol anaesthesia. Bacterial determined using the protected specimen brush (PSB) cut-off > or = 10(3) colony-forming units (CFU x mL(-1)). influence age, degree airflow...
Sensorineural hearing loss (SNHL) is the most common sensory impairment. Comprehensive next-generation sequencing (NGS) has become standard for etiological diagnosis of early-onset SNHL. However, accurate selection target genomic regions (gene panel/exome/genome), analytical performance and variant interpretation remain relevant difficulties its clinical implementation. We developed a novel NGS panel with 199 genes associated non-syndromic and/or syndromic evaluated sensitivity specificity...
Anterior craniofacial resection is a standardized procedure for the treatment of ethmoid and frontal orbital tumors with intracranial invasion.A retrospective review 100 patients sinonasal involving anterior skull base who underwent combined surgery at Hospital Central de Asturias.The most frequent pathologic entity was adenocarcinoma (53 cases) other epithelial (29 cases). Five-year actuarial survival according to Kaplan-Meier method 40%. Factors such as involvement surgical margins,...
Malignant ethmoid and maxillary sinus tumors frequently involve the orbit. Orbital involvement is an important prognostic predictor of recurrence-free, disease-specific, overall survival. Most authors agree that orbital preservation as opposed to exenteration or clearance does not result in significant differences local recurrence actuarial The eye can be safely preserved most patients with cancer invading wall, including malignancies invade soft tissues penetration through periorbita...
To evaluate the oncologic effectiveness of transoral laser surgery supraglottic cancer, we compared a group patients treated with surgery, stage-matched transcervical approach.Twenty-six who underwent were retrospectively 26 approach. In both groups, classified as follows: 8% stage I, 23% II, 46% III, and IV.The 5-year disease-specific survival rates 80% for 72% (p = .5). The ultimate laryngeal preservation rate was 86% in .6). arms, all T1 T2 survived 5 years after surgical treatment tumors...
This study aims to analyze the treatments, prognostic variables, and outcomes of patients with squamous cell carcinomas (SCC) external auditory canal (EAC) middle ear treated in our department over a 15-year period.A retrospective analysis 19 between 1990 2006. The were staged according Pittsburgh classification. Patients either lateral (LTBR) or an extended temporal bone resection (total subtotal). Parotidectomy was performed suspected clinical radiological invasion postoperative...
We analyzed the functional outcome and self-evaluation of voice patients with T1 glottic carcinoma treated endoscopic laser surgery radiotherapy. performed an objective evaluation, as well a physical, emotional being assessment 19 18 Voice quality is affected both by parameters only show differences in maximum phonation time between treatments. Results Handicap Index that radiotherapy has less effect on patient perception. There reduced impact patient's perception after radiotherapy, despite...
A large number of tumor types arise from the mucosa sinonasal cavities. Although presenting clinically distinct behavior, due to poorly differentiated histologic features, they can be difficult classify correctly. Our aim was investigate whether IDH2 and IDH1 mutations may specific a subset undifferentiated carcinomas. total 125 samples 7 different subtypes were analyzed for IDH by sequencing mutant-specific immunohistochemistry, results correlated clinical follow-up data. The highest...
Abstract Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding its clinical presentation, course, optimal limited, few advancements in improving management have been made recent past. Methods We conducted international multicenter retrospective analysis 505 SNMM cases from 11...
Several functional advantages have been described for the transoral laser supraglottic laryngectomy as compared with open techniques. However, comparative studies rarely performed.Functional results in 26 patients treated a approach were retrospectively those of comparable series who underwent transcervical approach.The only significant differences found between two groups lesser number temporary tracheotomies and shorter time removal nasogastric tube group. No incidence postoperative...
Abstract Background Sinonasal cancer carries a poor prognosis, especially in recurrent stages, and it is disease with very limited treatment options. Methods The expression of programmed death ligand‐1 (PD‐L1) as marker for immunotherapy was evaluated 53 sinonasal squamous cell carcinoma (SCC) 126 intestinal‐type adenocarcinoma (ITAC) samples. Results were correlated to clinicopathological characteristics follow‐up data. Membranous PD‐L1 staining tumor cells observed 34% (18/53) the SCC...
Abstract Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor carrying poor prognosis and needing new treatment options. The aim of this study was to identify actionable gene mutations that can guide personalized target-specific therapies in ITAC patients. A series 48 27 corresponding germline DNA samples were analyzed by next generation sequencing using panel 120 genes. In total, 223 sequence variants found 70 Matched tumor/germline comparison cases revealed 57% fact variants. 20...