A5074494578- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Cardiovascular and exercise physiology
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Health and Lifestyle Studies
- Ovarian function and disorders
- Physical Activity and Health
- Cardiovascular Health and Disease Prevention
- Pancreatic function and diabetes
- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Heart Rate Variability and Autonomic Control
- Cancer, Lipids, and Metabolism
- Cardiac Health and Mental Health
- Apelin-related biomedical research
- Birth, Development, and Health
University of Colorado Anschutz Medical Campus
2014-2024
Geriatric Research Education and Clinical Center
2018-2024
University of Colorado Denver
2005-2023
Veterans Health Administration
2014-2023
The Medical Center of Aurora
2018-2023
Rocky Mountain MS Center
2021-2022
United States Department of Veterans Affairs
2019
VA Eastern Colorado Health Care System
2018
Denver VA Medical Center
2005-2017
University of Washington
2010
To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes nondiabetic controls.Insulin was measured by three-stage hyperinsulinemic-euglycemic clamp (4, 8, 40 mU/m²/min) 87 subjects from the Coronary Artery Calcification Type Diabetes cohort (40 diabetic, 47 nondiabetic; mean age 45 ± 8 years; 55% female).Peripheral lower compared controls: infusion rate...
Type 1 diabetes is known to be a state of insulin resistance; however, the tissues involved in whole-body resistance are less well known. It unclear whether due glucose toxicity post-Diabetes Control and Complications Trial era tighter control.We performed this study determine muscle liver sensitivity individuals with type after overnight infusion lower fasting concentration.Fifty subjects [25 controls without 25 (diabetes duration 22.9 ± 1.7 yr, end organ damage] were frequency matched on...
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact endurance exercise training on molecular signaling within across tissues remains to be delineated. The Molecular Transducers Physical Activity Consortium (MoTrPAC) was established characterize networks underlying adaptive response exercise. Here, we describe studies undertaken by Preclinical Animal Sites Studies component MoTrPAC, in which sought develop implement standardized protocol large cohort...
To examine the impact of low-density lipoprotein (LDL), an established mediator atherosclerosis, on transcription factor cAMP-response element-binding protein (CREB), which is a regulator vascular smooth muscle cell (VSMC) quiescence.VSMC CREB content diminished in rodent models diabetes and pulmonary hypertension. We examined aortic aging, hypertension, insulin resistance, we determined nuclear medial VSMC high-fat-fed LDL receptor-null mice. There was significant loss all models. In vitro,...
Type 1 diabetes (T1D) is associated with insulin resistance despite elevated levels of the insulin-sensitizing protein adiponectin. Whether expected positive correlation between adiponectin and sensitivity preserved in a T1D population unknown.
Diabet. Med. 27, 1436–1442 (2010) Abstract Aims We investigated coronary artery calcium in association with glucose levels and variability measured using continuous monitoring adults Type 1 diabetes the Coronary Artery Calcification Diabetes study. Methods was by electron beam tomography. The presence of any analysed respect to [mean T (mean glucose), % values < 3.9 mmol/l, > 10 mmol/l either or mmol/l] glycaemic [ sd ( all values); dm daily mean levels) hh:mm (glucose for a specified...
People with type 1 diabetes (T1D) have markedly reduced insulin sensitivity (IS) compared to their nondiabetic counterparts, and IS is linked higher cardiovascular risk.This study aimed develop validate an improved method for estimating in people T1D.Prospective cohort.Adults (36 T1D, 41 nondiabetic) were recruited from the Coronary Artery Calcification Type Diabetes (CACTI) measurement of by hyperinsulinemic-euglycemic clamp a clinically useful prediction equation (eIS) T1D individuals....
OBJECTIVE Individuals with type 1 diabetes have a less atherogenic fasting lipid profile than those without but paradoxically increased rates of cardiovascular disease (CVD). We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects to better understand the etiology CVD risk. RESEARCH DESIGN AND METHODS Fast protein liquid chromatography was used fractionate substudy Coronary Artery Calcification Type Diabetes (CACTI) study (n =...
Diabet. Med. 28, 148–155 (2011) Abstract Aims Insulin resistance and dyslipidaemia both increase cardiovascular risk in Type 1 diabetes. However, little data exist on the associations of insulin to lipids Our objective was explore between (assessed by glucose infusion rate) people with diabetes determine whether adiposity and/or average glycaemia influence these associations. Methods Hyperinsulinaemic–euglycaemic clamp studies were performed 60 subjects aged 12–19 years (age 15 ± 2 years,...
Type 1 diabetes is an insulin-resistant state, but it less clear which tissues are affected. Our previous report implicated skeletal muscle and liver insulin resistance in people with type diabetes, this occurred independently of generalized, visceral, or ectopic fat. The aim the study was to measure adipose tissue sensitivity plasma triglyceride composition individuals after overnight infusion lower fasting glucose. Fifty subjects (25 25 controls without) were studied. After 3 d dietary...
Objective To determine the effect of lipid/heparin versus saline infusion, with or without concurrent euglycemic hyperinsulinemia, on serum follicle‐stimulating hormone (FSH) and luteinizing (LH). Obesity is associated hyperlipidemia, insulin resistance, relative hypogonadotropic hypogonadism. It was hypothesized that acutely elevated fatty acids would impair gonadotropin secretion. Methods Regularly cycling women men obesity underwent a crossover 6‐hour infusion study over four visits....
In rodents, loss of estradiol (E
Type 2 diabetes is associated with impaired exercise capacity. Alterations in both muscle perfusion and mitochondrial function can contribute to impairment. We hypothesized that type mediated, part, by decreased tissue oxygen delivery would improve supplementation. Ex vivo content respiration assessed from biopsy samples demonstrated expected differences obese individuals (n = 18) without 17) diabetes. Similarly, oxidative phosphorylation capacity measured the gastrocnemius via 31P-MRS...
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there evidence of various molecular pathways that affect these responses, a comprehensive map responses to exercise has not been developed. The Molecular Transducers Activity Consortium (MoTrPAC) multicenter study designed isolate the effects training on mechanisms underlying health benefits and physical activity. MoTrPAC contains both preclinical human component....
Introduction Obesity is characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism, reducing fertility increasing risk of pregnancy complications birth defects. We termed this phenotype ‘Reprometabolic Syndrome’ showed that it can be recapitulated acute infusions lipid/insulin into healthy, normal weight, eumenorrheic women. Herein, we examined the broader impact hyperlipidemia euglycemic hyperinsulinemia on anterior pituitary trophic hormones their...
Objective To examine the association between pericardial adipose tissue (PAT) and ratio of PAT to subcutaneous (SAT) with insulin resistance in adults without type 1 diabetes (T1D). Methods Data for this report came from a substudy Coronary Artery Calcification Type Diabetes cohort ( n = 83; 38 T1D, 45 T1D). Insulin was measured by hyperinsulinemic‐euglycemic clamp. Abdominal computed tomography (CT) used measure visceral (VAT) SAT. CT scans heart. Results SAT higher males compared females....
Abstract Aim Type 1 diabetes (T1D) increases the risk of morbidity and mortality from cardiovascular disease, insufficient sleep is prevalent. Emerging evidence suggests a link between cardiometabolic health, but this has not been examined across lifespan in individuals with T1D. We aimed to examine associations health adolescents adults T1D secondary analysis data 4‐week double‐blind, random‐order, placebo‐controlled crossover trial bromocriptine quick release (BCQR) therapy washout...