A5036018520- HIV-related health complications and treatments
- Nutrition and Health in Aging
- Physical Activity and Health
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Body Composition Measurement Techniques
- HIV/AIDS Research and Interventions
- Bone health and osteoporosis research
- Hormonal and reproductive studies
- Frailty in Older Adults
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Obesity, Physical Activity, Diet
- Sports injuries and prevention
- Health and Wellbeing Research
- Menopause: Health Impacts and Treatments
- Sports Performance and Training
- Occupational Health and Performance
- Balance, Gait, and Falls Prevention
- HIV Research and Treatment
- Thermoregulation and physiological responses
- Pediatric Pain Management Techniques
- Lower Extremity Biomechanics and Pathologies
University of Colorado Anschutz Medical Campus
2016-2025
Saint Louis University
2025
University of Wisconsin–Madison
2025
University of Colorado Denver
2014-2024
Colorado College
2013-2024
University of Washington
2023
Ronkowski (Poland)
2023
The Medical Center of Aurora
2023
Alexandra Hospital
2023
Oakland University
2022
Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer treatment that not proportional recent activity and interferes with usual functioning. It one the most common side effects in patients cancer. Fatigue has been shown be consequence active treatment, but it may also persist into posttreatment periods. Furthermore, difficulties end-of-life care can compounded by fatigue. The NCCN...
Background: The incidence of and risk factors for falls in HIV-1–infected persons are unknown. Methods: Fall history during the prior 12 months, medical diagnoses, functional assessments were collected on HIV-infected 45–65 years age receiving effective antiretroviral therapy. was evaluated using univariate multivariate regression analyses. Results: Of 359 subjects, 250 (70%) reported no falls, 109 (30%) had ≥1 fall; 66 (18%) recurrent fallers. Females, whites, smokers more likely to be...
Background. The relationships of inflammation, immune activation, and immunosenescence markers with functional impairment in aging human immunodeficiency virus type 1 (HIV-1)–infected persons are unknown.
Disability and frailty are associated with osteoporosis, obesity, sarcopenia. HIV-infected persons have early functional impairment, but the association between body composition impairment is unknown.HIV-1-infected participants on combination antiretroviral therapy virologic suppression, aged 45-65 years, had standardized physical function measures. In a nested analysis, 30 low- 48 high-functioning cases controls were matched by age, gender, time since HIV diagnosis. Bone mineral density,...
Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, RNA-seq datasets from eight control endurance exercise-trained (EET) rats. Integration of baseline mapped gene location dependence epigenetic features identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks EET showed little overlap...
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact endurance exercise training on molecular signaling within across tissues remains to be delineated. The Molecular Transducers Physical Activity Consortium (MoTrPAC) was established characterize networks underlying adaptive response exercise. Here, we describe studies undertaken by Preclinical Animal Sites Studies component MoTrPAC, in which sought develop implement standardized protocol large cohort...
The purpose was to compare the effects of three physical education settings (structured contact, nonstructured and no contact) on attitudes children toward peers with severe mental retardation who used wheelchairs. Contact theory (Allport, 1954) guided study. Participants were 131 Grade 4 students (62 females, 69 males) in intact classes that randomly assigned treatments. During experimental period (4 weeks, 20 sessions, each 25 min), two wheelchairs integrated into contact class, a special...
Context: It has been suggested that the propensity to store fat in gluteal-femoral region may be cardioprotective. Objective: The primary aim of this study was test whether favorable associations leg with risk factors for cardiovascular disease persist after controlling highly unfavorable effects abdominal (visceral or sc) adiposity postmenopausal women. Study Participants: included 95 women [age, 60 ± 8 yr (mean sd)]. Main Outcomes: Whole-body and regional distribution measured using...
Context: Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) decrease with aging are important androgen estrogen precursors in older adults. Declines DHEAS may contribute to physiological changes that sex hormone dependent. Objective: The aim was determine whether DHEA replacement increases bone mineral density (BMD) fat-free mass. Design, Setting, Participants: A randomized, double-blinded, controlled trial conducted at an academic research institution. Participants were 70 women men,...
The best method for assessment of functional status in human immunodeficiency virus type 1 (HIV-1) infected persons is unknown.We hypothesized that 3 instruments to assess frailty or disability elderly populations would perform similarly HIV-1-infected persons.HIV-infected subjects 45 65 years old with plasma HIV-1 RNA <48 copies/mL were classified prospectively as low, moderate, high function by Fried's phenotype (FFP), the Short Physical Performance Battery (SPPB), and 400-m walk test....
Objective: Whether older people living with HIV (PLWH) can achieve similar functional benefits exercise as their uninfected peers and the ideal intensity of needed for these are not known. Design: Sedentary adults (50–75 years) or without were recruited 24 weeks supervised endurance/resistance exercise. After 12 moderate-intensity exercise, participants randomized to continue advance high-intensity an additional weeks. Methods: Outcomes by serostatus (moderate, high) compared using linear...
Introduction With the advent of effective antiretroviral therapy (ART), care persons living with HIV (PLWH) is shifting focus to management age-related chronic health conditions (e.g. metabolic syndrome and cardiovascular disease), syndromes ageing dementia frailty) side effects related ART. Non-ART polypharmacy common among PLWH associated an increasing risk hospitalization mortality [1]; thus, nonpharmacologic comorbidities critical for who may experience earlier onset a greater burden...
Previously, we reported significant bone mineral density (BMD) loss in postmenopausal women after modest weight loss. It remains unclear whether the magnitude of BMD change response to is appropriate (i.e., proportional loss) and recovered with regain. We now report changes a 1-year follow-up. Subjects (n = 23) this secondary analysis were randomized placebo as part larger trial. They completed 6-month exercise-based program returned for follow-up at 18 months. Dual-energy X-ray...
Objective: Physical function impairments are seen among aging, HIV-infected persons on effective antiretroviral therapy (ART). The impact of physical health-related quality life (QoL) during ART is unknown. Design: This was a cross-sectional study including 359 patients, aged 45–65 years, for more than 6 months. Methods: Patients completed the SF-36 QoL questionnaire, 400-m walk, 5-time chair rise, and grip strength. HIV-associated mortality risk calculated using Veterans Aging Cohort Study...
Objective: To determine the relative contributions of adiposity and muscularity to multi‐dimensional performance‐based perceived physical function in older adults living independently. Methods Procedures: Data from 109 women men, aged 60 or older, with low serum dehydroepiandrosterone (DHEA) sulfate levels were included this cross‐sectional analysis baseline measures a single‐site, randomized, controlled trial DHEA replacement therapy. Physical was determined by means performance on...
Introduction: The aim of this study was to characterize perceptions wearable and smart home technologies older women using semi-structured interviews.Methods Procedures: Participants (n = 10) were shown two sensors a sensor. All participants 60 years age or with the exception one participant (ages: 57-70,average age: 64.6 years). Sensor function placement explained. asked questions about technology, sensors, thoughts use these types sensors. Interview transcripts analyzed identify themes...
Physiologic aging has been associated with gut dysbiosis. Although short exercise interventions have linked to beneficial changes in microbiota younger adults, limited data are available from older populations. We hypothesized that would produce shifts and short-chain fatty acid (SCFA) levels persons.Stool samples were collected before at completion of a supervised 24-week cardiovascular resistance intervention among 50-75-year-old participants. SCFA analyzed by gas chromatography microbiome...
Background: Significant heterogeneity in individual responses to exercise interventions provides an opportunity identify individuals for whom modifications or adjunct therapies may be necessary. Here, we explore of response among people with HIV (PWH) versus without (control). Methods: The Exercise Healthy Aging Study enrolled sedentary older PWH and controls (50-75 years old) a 24-week aerobic resistance program. Responder groups were categorized based on minimally clinically important...
Context: The mechanisms by which dehydroepiandrosterone (DHEA) replacement increases bone mineral density (BMD) in older adults are not known. Objective: aims were to determine the effects of DHEA therapy on changes sex hormones and IGF-I their associations with BMD. Design, Setting, Participants: A randomized, double-blinded, placebo-controlled trial was conducted at an academic research institution. Participants 58 women 61 men, aged 60–88 yr, low serum sulfate (DHEAS) levels....