Chia-Jui Hung
A5052920867- Gut microbiota and health
- Adipose Tissue and Metabolism
- Reproductive tract infections research
- Exercise and Physiological Responses
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Circadian rhythm and melatonin
- Urinary Tract Infections Management
- Microbial Metabolites in Food Biotechnology
- Food composition and properties
- Genetics and Physical Performance
- Birth, Development, and Health
Stanford University
2022-2024
Stanford Medicine
2022
Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders cancer. To understand benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (AX) long-chain inulin (LCI), a mixture five fibers. We present multiomic signatures metabolomics, lipidomics, proteomics, metagenomics, cytokine panel, clinical measurements on healthy insulin-resistant participants. Each is associated with fiber-dependent...
The vaginal microbiome's composition varies among ethnicities. However, the evolutionary landscape of microbiome in multi-ethnic context remains understudied. We perform a systematic analysis 351 samples from 35 pregnant women, addition to two validation cohorts, totaling 462 90 women. Microbiome alpha diversity and community state dynamics show strong ethnic signatures. Lactobacillaceae have higher ratio non-synonymous synonymous polymorphism lower nucleotide than non-Lactobacillaceae all...
Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, RNA-seq datasets from eight control endurance exercise-trained (EET) rats. Integration of baseline mapped gene location dependence epigenetic features identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks EET showed little overlap...
Abstract Regular exercise promotes whole-body health and prevents disease, yet the underlying molecular mechanisms throughout a whole organism are incompletely understood. Here, Molecular Transducers of Physical Activity Consortium (MoTrPAC) profiled temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome, immunome in blood, plasma, 18 solid tissues Rattus norvegicus over 8 weeks endurance training. The resulting data compendium...
Abstract The vaginal microbiome is important for reproductive health and should constantly evolve in response to dynamic host-microbe interactions. composition of the associated with ethnicity; however, evolutionary landscape microbiome, especially multi-ethnic context, remains under-studied. In this study, we performed a longitudinal analysis 351 samples from 35 pregnant women diverse ethnic backgrounds validated main findings two cohorts totaling 462 90 women. Microbiome alpha diversity...