Cynthia L. Stowe
A5078976201- Adipose Tissue and Metabolism
- Physical Activity and Health
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Genetics and Physical Performance
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Cerebral Palsy and Movement Disorders
- Peripheral Artery Disease Management
- Body Composition Measurement Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Health, Environment, Cognitive Aging
- Eating Disorders and Behaviors
- Biomedical Ethics and Regulation
- Obesity, Physical Activity, Diet
- Circadian rhythm and melatonin
- Fault Detection and Control Systems
- Ethics in Clinical Research
- Lymphatic System and Diseases
- Balance, Gait, and Falls Prevention
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
Wake Forest University
2013-2025
Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood
Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, RNA-seq datasets from eight control endurance exercise-trained (EET) rats. Integration of baseline mapped gene location dependence epigenetic features identified differing regulatory landscapes in each tissue. The transcriptional responses to 8 weeks EET showed little overlap...
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact endurance exercise training on molecular signaling within across tissues remains to be delineated. The Molecular Transducers Physical Activity Consortium (MoTrPAC) was established characterize networks underlying adaptive response exercise. Here, we describe studies undertaken by Preclinical Animal Sites Studies component MoTrPAC, in which sought develop implement standardized protocol large cohort...
https://youtu.be/KAfCLUuf1XY INTRODUCTION The Molecular Transducers of Physical Activity Consortium (MoTrPAC) protocol includes collection cardiopulmonary exercise testing (CPET) data as a key clinical outcome. Due to the large volume and institutions involved in MoTrPAC, CPET Core Lab was created manage repository, evaluate quality, analyze metabolic events continuous like ventilatory thresholds (VT). METHODS All centers MoTrPAC conducted CPETs on cycle ergometers following individualized...
Abstract Regular exercise promotes whole-body health and prevents disease, yet the underlying molecular mechanisms throughout a whole organism are incompletely understood. Here, Molecular Transducers of Physical Activity Consortium (MoTrPAC) profiled temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome, immunome in blood, plasma, 18 solid tissues Rattus norvegicus over 8 weeks endurance training. The resulting data compendium...
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there evidence of various molecular pathways that affect these responses, a comprehensive map responses to exercise has not been developed. The Molecular Transducers Activity Consortium (MoTrPAC) multicenter study designed isolate the effects training on mechanisms underlying health benefits and physical activity. MoTrPAC contains both preclinical human component....
To investigate whether baseline social participation modifies the effect of a long-term structured physical activity (PA) program on major mobility disability (MMD). 1,635 sedentary adults (70–89 years) with limitations were randomized to either PA or health education (HE) intervention. Social was defined categorically at baseline. High as attending organized group functions least once per week and visiting noncohabitating friends family ≥7 hr week. Anything less considered limited...
Background Overweight and obesity are associated with adverse functional outcomes in people peripheral artery disease (PAD). The effects of weight loss overweight/obesity PAD unknown. Methods PROVE (Promote Weight Loss Obese Patients to Prevent Mobility Loss) Trial is a multicentered randomized clinical trial the primary aim testing whether behavioral intervention designed help participants lose walk for exercise improves 6-minute distance at 12-month follow-up, compared walking alone. A...