A5083192238- Treatment of Major Depression
- Obsessive-Compulsive Spectrum Disorders
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Laser Applications in Dentistry and Medicine
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Medical and Biological Ozone Research
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Advanced Radiotherapy Techniques
- Optical Imaging and Spectroscopy Techniques
- Extracellular vesicles in disease
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Eating Disorders and Behaviors
- MicroRNA in disease regulation
- Pain Management and Placebo Effect
- Pediatric Pain Management Techniques
- Genetic Neurodegenerative Diseases
Nathan Kline Institute for Psychiatric Research
2019-2025
Duke University
2022-2024
Australian Radiation Protection and Nuclear Safety Agency
2023-2024
Boston Children's Hospital
2018-2023
Icahn School of Medicine at Mount Sinai
2012-2021
Center for Discovery
2019-2021
Paradigm Pharmaceuticals (United States)
2020
Roswell Park Comprehensive Cancer Center
2018-2019
Boston Children's Museum
2018
Pennsylvania State University
2018
The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play abetting growth are unclear.We analyzed clinical data on 619 patients with epithelial to test associations between platelet counts disease outcome. Human samples mouse models were used explore underlying thrombocytosis. effects tumor angiogenesis ascertained.Thrombocytosis was significantly associated advanced shortened survival. Plasma levels thrombopoietin interleukin-6 elevated who had as...
The N-methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine may have rapid, albeit transient, antidepressant properties. This study in patients with treatment-resistant major depression (TRD) aimed to (1) replicate the acute efficacy of single-dose intravenous (i.v.) ketamine; (2) test glutamate-modulating agent riluzole preventing post-ketamine relapse; and (3) examine whether pretreatment lamotrigine would attenuate ketamine's psychotomimetic effects enhance its activity....
Background. Suicide is a devastating public health problem and very few biological treatments have been found to be effective for quickly reducing the intensity of suicidal ideation (SI). We previously shown that single dose ketamine, glutamate N -methyl- d -aspartate (NMDA) receptor antagonist, associated with rapid reduction in depressive symptom severity SI patients treatment-resistant depression. Method. conducted randomized, controlled trial ketamine mood anxiety spectrum disorders who...
Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors' previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine infusion in individuals with PTSD showed significant rapid symptom reduction 24 hours postinfusion. present study the first to test efficacy safety repeated infusions treatment PTSD.Individuals (N=30) were randomly assigned (1:1) receive six (0.5 mg/kg) or...
Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are both currently used for treatment-resistant major depression, but the comparative effectiveness of two treatments remains uncertain.We conducted an open-label, randomized, noninferiority trial involving patients referred to ECT clinics depression. Patients with depression without psychosis were recruited assigned in a 1:1 ratio receive or ECT. During initial 3-week treatment phase, received either three times per week...
Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism initiation unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal fibroblasts (HADF) and cause extracellular acidification. HMEX were isolated from supernatants six melanoma cell lines (3 BRAF V600E mutant 3 wild-type lines) using ultracentrifugation or Size Exclusion Chromatography (SEC). Rapid uptake by HADF was demonstrated following 18...
Abstract Background Major depressive disorder is a disabling neuropsychiatric condition that associated with disrupted functional connectivity across brain networks. The precise nature of altered connectivity, however, remains incompletely understood. current study was designed to examine the coherence large‐scale in depression using recently developed technique termed global connectivity. Methods: A total 82 subjects, including medication‐free patients major ( n = 57) and healthy volunteers...
The glutamate N-methyl-D-aspartate receptor antagonist ketamine has demonstrated antidepressant effects in individuals with treatment-resistant major depressive disorder (TRD) within 24 h of a single dose. current study utilized functional magnetic resonance imaging (fMRI) and two separate emotion perception tasks to examine the neural patients TRD. One task used happy neutral facial expressions; other sad expressions. Twenty TRD free concomitant medication underwent fMRI at baseline...
Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature immune dysfunction remains unclear, evidence from animal studies points towards a dysregulated response leukocytes as risk factor for stress susceptibility. This study examined dynamic release inflammatory blood factors mononuclear cells (PBMC) depressed patients associations neural behavioral measures reward processing. Thirty...
Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for treatment of depression and anhedonia, reduced ability experience pleasure. The authors conducted first randomized placebo-controlled trial testing effect positive modulator ezogabine on reward circuit activity clinical outcomes in patients with depression.Depressed individuals (N=45) elevated levels anhedonia were assigned 5-week period (900 mg/day; N=21) or placebo (N=24). Participants underwent functional MRI...
Although hyperkinesis is expressed in several neurological disorders, the biological basis of this phenotype unknown. The mouse mutant coloboma ( Cm /+) exhibits profound spontaneous locomotor hyperactivity resulting from a deletion mutation. This encompasses genes including Snap , which encodes SNAP-25, nerve terminal protein involved neurotransmitter release. Administration amphetamine, drug that acts presynaptically, markedly reduced activity mice but increased control implicating...
Background There is an urgent need for more effective treatments major depressive disorder (MDD). As understanding of the cognitive and affective neuroscience underlying psychiatric disorders expands, so do opportunities to develop interventions that capitalize on capacity brain plasticity. Cognitive training one such strategy. In this article, we report a proof-of-concept study novel cognitive-emotional exercise designed enhance control emotional information processing targeting components...
Heart failure (HF) is a debilitating and life-threatening condition, with 5-year survival rate lower than breast or prostate cancer. It the leading cause of hospital admission in over 65s, these admissions are projected to rise by more 50% next 25 years. Transthoracic echocardiography (TTE) first-line step diagnosis acute chronic HF provides immediate information on chamber volumes, ventricular systolic diastolic function, wall thickness, valve function presence pericardial effusion, while...
Anxiety and trauma-related disorders are among the most prevalent disabling medical conditions in United States, posttraumatic stress disorder particular exacts a tremendous public health toll. We examined tolerability anxiolytic efficacy of neuropeptide Y administered via an intranasal route patients with disorder.Twenty-six individuals were randomized cross-over, single ascending dose study into 1 5 cohorts: 1.4 mg (n=3), 2.8 (n=6), 4.6 (n=5), 6.8 9.6 (n=6). Each individual was dosed or...
Chronic fatigue syndrome (CFS), a complex illness characterized by fatigue, impaired concentration, and musculoskeletal pain, is often misdiagnosed as psychiatric due to the overlap of its symptoms with mood anxiety disorders. Using proton magnetic resonance spectroscopic imaging ((1)H MRSI), we previously measured levels major brain metabolites in CFS, generalized disorder (GAD), healthy control subjects, found significantly higher ventricular cerebrospinal fluid (CSF) lactate CFS compared...
The ability to take action in the face of threat is highly diverse across individuals. What are neural processes that determine individual differences cope with danger? We hypothesized extent synchronization between amygdala, striatum, and medial prefrontal cortex (mPFC) would predict successful active coping performance. To test this, we developed a novel computer task based on principals Sidman avoidance. Healthy human participants learned through trial error move marker virtual game board...