A5052704510- Treatment of Major Depression
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Anesthesia and Neurotoxicity Research
- Mental Health Research Topics
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Pediatric Pain Management Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroendocrine regulation and behavior
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Bipolar Disorder and Treatment
- Social Media in Health Education
- Digital Media and Visual Art
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurology and Historical Studies
- Immune Cell Function and Interaction
- Conferences and Exhibitions Management
- Neurotransmitter Receptor Influence on Behavior
- GDF15 and Related Biomarkers
- Diet and metabolism studies
University of Oxford
2022-2025
Icahn School of Medicine at Mount Sinai
2016-2025
Oxford Health NHS Foundation Trust
2021-2025
Warneford Hospital
2022-2025
Center for Discovery
2019-2025
Center for Anxiety and Depression
2022
National Health Service
2022
Nathan Kline Institute for Psychiatric Research
2021
Wellcome Trust
2021
Luigi Sacco Hospital
2020
Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors' previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine infusion in individuals with PTSD showed significant rapid symptom reduction 24 hours postinfusion. present study the first to test efficacy safety repeated infusions treatment PTSD.Individuals (N=30) were randomly assigned (1:1) receive six (0.5 mg/kg) or...
Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are both currently used for treatment-resistant major depression, but the comparative effectiveness of two treatments remains uncertain.We conducted an open-label, randomized, noninferiority trial involving patients referred to ECT clinics depression. Patients with depression without psychosis were recruited assigned in a 1:1 ratio receive or ECT. During initial 3-week treatment phase, received either three times per week...
Abstract Psychosocial stress has profound effects on the body, including immune system and brain 1,2 . Although a large number of pre-clinical clinical studies have linked peripheral alterations to stress-related disorders such as major depressive disorder (MDD) 3 , underlying mechanisms are not well understood. Here we show that expression circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in serum humans with MDD stress-susceptible mice following...
Abstract A subset of patients with depression have elevated levels inflammatory cytokines, and some studies demonstrate interaction between factors treatment outcome. However, most focus on only a narrow in patient sample. In the current study, we analyzed broad immune profiles blood from treatment-resistant (TRD) at baseline following glutamate modulator ketamine. Serum was 26 healthy control 33 actively depressed TRD free antidepressant medication, matched for age, sex body mass index. All...
Abstract Increased levels of peripheral cytokines have been previously associated with depression in preclinical and clinical research. Although the precise nature immune dysfunction remains unclear, evidence from animal studies points towards a dysregulated response leukocytes as risk factor for stress susceptibility. This study examined dynamic release inflammatory blood factors mononuclear cells (PBMC) depressed patients associations neural behavioral measures reward processing. Thirty...
Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for treatment of depression and anhedonia, reduced ability experience pleasure. The authors conducted first randomized placebo-controlled trial testing effect positive modulator ezogabine on reward circuit activity clinical outcomes in patients with depression.Depressed individuals (N=45) elevated levels anhedonia were assigned 5-week period (900 mg/day; N=21) or placebo (N=24). Participants underwent functional MRI...
Anxiety and trauma-related disorders are among the most prevalent disabling medical conditions in United States, posttraumatic stress disorder particular exacts a tremendous public health toll. We examined tolerability anxiolytic efficacy of neuropeptide Y administered via an intranasal route patients with disorder.Twenty-six individuals were randomized cross-over, single ascending dose study into 1 5 cohorts: 1.4 mg (n=3), 2.8 (n=6), 4.6 (n=5), 6.8 9.6 (n=6). Each individual was dosed or...
Abstract Ultra-high field 7-Tesla (7 T) MRI has the potential to advance our understanding of neuropsychiatric disorders, including major depressive disorder (MDD). To date, few studies have quantified advantage resting state functional (fMRI) at 7 T compared 3-Tesla (3 T). We conducted a series experiments that demonstrate improvement in temporal signal-to-noise ratio (TSNR) multi-echo multi-band fMRI protocol with ultra-high MRI, similar using 3 healthy controls (HC). also directly tested...
Abstract Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD associated a pro-inflammatory state ketamine may inhibit inflammatory processes. We thus investigated whole blood transcriptional profiles related to gene expression changes treatment response ketamine. Whole was collected at baseline (21 healthy controls [HC], 26...
The renin angiotensin system (RAS) is implicated in various cognitive processes relevant to anxiety. However, the role of RAS pattern separation, a hippocampal memory mechanism that enables discrete encoding similar stimuli, unclear. Given proposed this overgeneralization and maintenance anxiety, we explored influence on mnemonic discrimination i.e., behavioral ability arising from separation. In double-blind experimental medicine trial, examined effect losartan, an receptor blocker, N = 60...
Clinical studies have revealed a high comorbidity between autoimmune diseases and psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms connecting autoimmunity depression remain unclear. Here, we aim to identify processes by which stress impacts adaptive immune system implications of such responses depression. To examine this relationship, analyzed antibody in chronic social defeat (CSDS) model mice, clinical samples from patients with MDD. We show that...
The aim of this review was to summarize current knowledge on the correlation between depressive symptoms with a syndrome called partial androgen deficiency aging male (PADAM) and potential benefits testosterone (T) treatment mood. Despite, causative nature relationship low T levels depression is uncertain, many hypogonadal men suffer from vice versa several depressed patients are affected by hypogonadism. Supplementation failed show sound evidence effectiveness in depression. Nevertheless,...
Importance The ELEKT-D: Electroconvulsive Therapy (ECT) vs Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D) trial demonstrated noninferiority of intravenous ketamine ECT for nonpsychotic TRD. Clinical features that can guide selection may inform shared decision-making patients with Objective To evaluate whether selected clinical were associated differential improvement ECT. Design, Setting, and Participants This secondary analysis an open-label randomized was a...
Objective: Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors’ previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine infusion in individuals with PTSD showed significant rapid symptom reduction 24 hours postinfusion. present study the first to test efficacy safety repeated infusions treatment PTSD. Methods: Individuals (N=30) were randomly assigned (1:1) receive...