A5026510420- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Educational Innovations and Technology
- Social Skills and Education
- Online Learning and Analytics
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Educational Technology in Learning
- Educational Outcomes and Influences
- Chronic Obstructive Pulmonary Disease (COPD) Research
- E-Learning and Knowledge Management
- Education and Teacher Training
- Stress and Burnout Research
- Online and Blended Learning
- Exercise and Physiological Responses
- Sulfur Compounds in Biology
- Respiratory and Cough-Related Research
- Adolescent Health and Behaviors
- Foreign Language Teaching Methods
- Medicinal Plants and Bioactive Compounds
- Forensic Toxicology and Drug Analysis
Universitat de València
1989-2024
Icahn School of Medicine at Mount Sinai
1998-2024
Allen Institute for Brain Science
2022-2023
Universidad de Zaragoza
2021-2022
Hospital Universitario Doctor Peset
1999-2010
Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly...
Abstract Psychosocial stress has profound effects on the body, including immune system and brain 1,2 . Although a large number of pre-clinical clinical studies have linked peripheral alterations to stress-related disorders such as major depressive disorder (MDD) 3 , underlying mechanisms are not well understood. Here we show that expression circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in serum humans with MDD stress-susceptible mice following...
Clinical studies have revealed a high comorbidity between autoimmune diseases and psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms connecting autoimmunity depression remain unclear. Here, we aim to identify processes by which stress impacts adaptive immune system implications of such responses depression. To examine this relationship, analyzed antibody in chronic social defeat (CSDS) model mice, clinical samples from patients with MDD. We show that...
Administration of oral glutathione (GSH) increases hepatic GSH levels in fasted rats, mice treated with depletors such as diethyl maleate and high doses paracetamol. An increase after administration does not occur animals buthionine sulphoximine, an inhibitor synthesis. leads to the concentration l-cysteine, a precursor GSH, portal blood plasma. Oral l-methionine produced significant decrease ATP but fed rats. N −acetylcysteine or did affect levels. The results show that intake is safe...
The experience of social stress during adolescence is associated with higher vulnerability to drug use. Increases in the acquisition cocaine self-administration, escalation cocaine-seeking behavior, and conditioned rewarding effects have been observed rodents exposed repeated defeat (RSD). In addition, prolonged or severe induces a proinflammatory state microglial activation increased cytokine production. aim present work was describe long-term induced by RSD on neuroinflammatory response...
Social defeat is considered the most representative animal model for studying consequences of social stress. Intermittent (ISD) has proved to enhance response cocaine hedonic properties. In present research, we evaluated if different housing conditions, as with a familiar conspecific or female, exert protective effect modulating negative ISD increased sensitivity and induction anxiety-like behavior. To achieve this objective, non-stressed OF1 male mice were divided into five experimental...
It is well established that repeated social defeat stress can induce negative long-term consequences such as increased anxiety-like behavior and enhances the reinforcing effect of psychostimulants in rodents. In current study, we evaluated how immune system may play a role these effects stress. A total 148 OF1 mice were divided into different experimental groups according to condition (exploration or defeat) pre-treatment (saline, 5 10 mg/kg anti-inflammatory indomethacin) before each...
The kynurenine (KYN) pathway of tryptophan (TRP) degradation is activated by stress and inflammatory factors. It now well established that social induces the activation immune system, with central inflammation KYN metabolism being two main factors linking depression. aim present study was to evaluate long-lasting changes in induced defeat (SD) associated resilience or susceptibility an increase conditioned rewarding effects cocaine. Mice were exposed repeated SD 3 weeks later, a place...
Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability drug abuse, increasing the consumption of ethanol. However, not all subjects are equally affected by changes induced stress. Previous reports have evidenced resilient phenotype depressive-like behaviors after SD is associated with resistant cocaine-increased rewarding effects and smaller neuroinflammatory response. The aim present study was further clarify whether profile behavior also predicts a...
Abstract Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased ethanol seeking and consumption, accompanied by activation of the neuroinflammatory response. However, resilient response can be potentiated through physical exercise in form voluntary wheel running (VWR) during or after exposure stress. Therefore, aim this study was test whether adolescence prior being exposed SD enhance resilience increase intake. Methods Male mice had access VWR effects (4 sessions...
The present paper evaluates the effect of physical activity on increase conditioned rewarding effects cocaine induced by intermittent social stress and neuroinflammatory response that contributes to enhancement drug response. For purpose, three studies were designed in which was different samples mice through a social-defeat protocol; underwent an modalities voluntary wheel running (continuous access). results showed continuous access wheels prior enhanced establishment place preference,...