A5024294784- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Prenatal Substance Exposure Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Forensic Toxicology and Drug Analysis
- Biochemical effects in animals
- Birth, Development, and Health
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Child and Adolescent Psychosocial and Emotional Development
Universidad Complutense de Madrid
2011-2021
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2011-2016
Consejo Superior de Investigaciones Científicas
2015
Instituto Cajal
2015
Universidade de São Paulo
2015
Fundação Oswaldo Cruz
2015
Hospital Clínico San Carlos
2012
Ministerio de Educación y Cultura
2005
Ministerio de Ciencia y Tecnología
2005
Austral University of Chile
2002
Cannabinoids, endocannabinoids and marijuana activate two well-characterized cannabinoid receptors (CB-Rs), CB1-Rs CB2-Rs. The expression of in the brain periphery has been well studied, but neuronal CB2-Rs have received much less attention than CB1-Rs. Many studies now identified characterized functional glial central nervous system. However, many features CB2-R gene structure, regulation variation remain poorly comparison with CB1-R. In this study, we report on discovery a novel human CB2...
Abstract Early maternal deprivation (MD) in rats (24 h, postnatal day 9–10) is a model for neurodevelopmental stress. There are some data proving that MD affects the endocannabinoid system (ECS) gender‐dependent manner, and these changes may account proposed schizophrenia‐like phenotype of rats. The impact on cannabinoid receptor distribution hippocampus unknown. aim this study to evaluate expression CB 1 2 receptors diverse relevant subregions (DG, CA1, CA3) 13‐day‐old by...
We have studied the possible interaction between cannabinoid receptor agonist CP 55,940 (1 and 50 μg/kg) 5-HT1A antagonist WAY 100635 mg/kg) in modulation of plus-maze holeboard activity Wistar adult male rats. In plus-maze, higher dose induced an anxiogenic-like effect, whereas lower anxiolytic-like responses. The antagonist, which was silent this test, attenuated anxiogenic, but not anxiolytic, effect 55,940. holeboard, significantly decreased head-dipping duration, 100635, did affect...
Adult animals submitted to a single prolonged episode of maternal deprivation [24h, postnatal day 9-10] show behavioral alterations that resemble specific symptoms schizophrenia. According the neurodevelopmental theory, these deficits might be mediated by detrimental processes associated, at least partially, with stress-induced corticosterone responses. In order address this hypothesis, we have focused on hippocampus and cerebellar cortex, two brain regions high density glucocorticoid...
We have analysed the long-term effects of adolescent (postnatal day 28–43) exposure male and female rats to nicotine (NIC, 1.4 mg/kg/day) and/or cannabinoid agonist CP 55,940 (CP, 0.4 on following parameters measured in adulthood: (1) memory ability evaluated object location task (OL) novel test (NOT); (2) anxiety-like behaviour elevated plus maze; (3) nicotinic CB 1 receptors cingulated cortex hippocampus. In OL, all pharmacological treatments induced significant decreases DI females,...
We have analysed the long-term psychoneuroendocrine effects of maternal deprivation (MD) [24 h at postnatal day (PND) 9] and/or exposure to chronic unpredictable stress (CUS) during periadolescent period (PND 28 PND 43) in male and female Wistar rats. Animals were tested elevated plus maze (EPM, anxiety) 44 two memory tests, spontaneous alternation novel object recognition (NOT) adulthood. The expression hippocampal glucocorticoid (GR) mineralocorticoid (MR) receptors, as well synaptophysin,...
The endocannabinoid system is involved in several physiological and pathological states including anxiety, depression, addiction other neuropsychiatric disorders. Evidence from human rodent studies suggests that exposure to early life stress may increase the risk of psychopathology later life. Indeed, maternal deprivation (MD) (24 h at postnatal day 9) rats induces behavioural alterations associated with depressive-like psychotic-like symptoms, as well important changes system. As most...
ABSTRACT Early life experiences such as maternal deprivation (MD) exert long‐lasting changes in adult behaviour and reactivity to stressors. Adolescent exposure cannabinoids is a predisposing factor developing certain psychiatric disorders. Therefore, the combination of two factors could exacerbate negative consequences each when evaluated at adulthood. The objective this study was investigate long‐term effects early MD [24 hours postnatal day (PND) 9] and/or an adolescent chronic treatment...
Traumatic brain injury (TBI) and its consequences represent one of the leading causes death in young adults. This lesion mediates glial activation release harmful molecules edema, axonal injury, functional impairment. Since plays a key role development this damage, it seems that controlling could be beneficial lead to neuroprotective effects. Recent studies show minocycline suppresses microglial activation, reduces volume, decreases TBI-induced locomotor hyperactivity up 3 months. The...
Preclinical and clinical data suggest that cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa, induces antipsychotic-like effects. However, the antipsychotic properties of repeated CBD treatment have been poorly investigated. Behavioral changes induced by with glutamate N-methyl-D-aspartate receptor (NMDAR) antagonists proposed as an animal model schizophrenia-like signs. In present study, we evaluated if would attenuate behavioral molecular modifications chronic...
Traumatic brain injury (TBI) incidence rises during adolescence because this critical neurodevelopmental period some risky behaviors increase. The purpose of study was to assess the contribution cannabinoid receptors (CB1 and CB2), blood barrier proteins (AQP4) astrogliosis markers (vimentin) neurological deficit edema formation in a TBI weight drop model adolescent male mice. These molecules were selected since they are known change shortly after lesion. Here we extended their three...