A5026877622- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Pharmacology and Obesity Treatment
- Cancer-related cognitive impairment studies
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Natural Compound Pharmacology Studies
- Prenatal Substance Exposure Effects
- Musculoskeletal pain and rehabilitation
- Pancreatic function and diabetes
- Forensic Toxicology and Drug Analysis
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Placebo Effect
- Biochemical Analysis and Sensing Techniques
Ollscoil na Gaillimhe – University of Galway
2020-2025
University Hospital Galway
2024-2025
Universidad Rey Juan Carlos
2024
Universidad Autónoma de Madrid
2024
National University of Ireland
2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2011-2016
Universidad Complutense de Madrid
2008-2015
Hospital Clínico San Carlos
2012
Cannabinoids, endocannabinoids and marijuana activate two well-characterized cannabinoid receptors (CB-Rs), CB1-Rs CB2-Rs. The expression of in the brain periphery has been well studied, but neuronal CB2-Rs have received much less attention than CB1-Rs. Many studies now identified characterized functional glial central nervous system. However, many features CB2-R gene structure, regulation variation remain poorly comparison with CB1-R. In this study, we report on discovery a novel human CB2...
Adult animals submitted to a single prolonged episode of maternal deprivation [24h, postnatal day 9-10] show behavioral alterations that resemble specific symptoms schizophrenia. According the neurodevelopmental theory, these deficits might be mediated by detrimental processes associated, at least partially, with stress-induced corticosterone responses. In order address this hypothesis, we have focused on hippocampus and cerebellar cortex, two brain regions high density glucocorticoid...
ABSTRACT Early life experiences such as maternal deprivation (MD) exert long‐lasting changes in adult behaviour and reactivity to stressors. Adolescent exposure cannabinoids is a predisposing factor developing certain psychiatric disorders. Therefore, the combination of two factors could exacerbate negative consequences each when evaluated at adulthood. The objective this study was investigate long‐term effects early MD [24 hours postnatal day (PND) 9] and/or an adolescent chronic treatment...
Abstract Adult animals submitted to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal days (PND) 9–10] show behavioral alterations that resemble specific symptoms schizophrenia. These impairments may be related neuronal loss in the hippocampus triggered by elevated glucocorticoids. Furthermore, our previous data suggested functional relationships between MD stress and endocannabinoid system. In this study, we addressed effects on hippocampal glial cells possible...
Paclitaxel (PTX) is a commonly used chemotherapeutic drug, however, one of its major adverse effects chronic neuropathic pain, with the incidence being higher in women than men. The neurobiological mechanisms behind this sex difference are still largely unclear, and endocannabinoid system, which exhibits sexual dimorphism plays key role pain regulation, promising area for further studies. present study aimed to characterise pain-, cognition-, anxiety-, depression-related behaviours male...
Many young people consume ecstasy as a recreational drug and often in combination with cannabis. In this study, we aimed to mimic human consumption patterns investigated, male female animals, the long-term effects of Δ(9) -tetrahydrocannabinol (THC) 3,4-methylenedioxymethamphetamine (MDMA) on diverse neuroinflammation neurotoxic markers.
Maternal deprivation (MD) during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours the period reduces body weight throughout when animals are maintained on a normal diet. However, little information is available regarding how this early stress affects response to increased metabolic challenges postnatal life. We hypothesized that modifies high fat diet (HFD) and differs between males females. To address question, both male female Wistar...
Ecstasy is a drug that usually consumed by young people at the weekends and frequently, in combination with cannabis. In present study we have investigated long-term effects of administering increasing doses delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or conjunction 3,4-methylenedioxymethamphetamine [MDMA; two daily mg/kg every 5 days; s.c.] pnd 30 both male female Wistar rats. When tested one after end pharmacological treatment...
Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental characterized by impairment in social, communication skills and stereotype behaviors. While autism may be uniquely human, there behavioral characteristics ASDs that can mimicked using animal models. We used the BTBR T+tf/J mice have been shown to exhibit autism-like phenotypes 1). Evaluate cannabinoid-induced changes forced swim test (FST) spontaneous wheel running (SWR) activity 2). Determine neurochemical after...
Chronic neuropathic pain is a major unmet clinical need affecting 10% of the world population, majority whom suffer from co-morbid mood disorders. Sex differences have been reported in prevalence, perception and response to analgesics. However, sexual dimorphism chronic associated neurobiology, are still poorly understood. The lack efficacy adverse effects with current pharmacological treatments, further underline for new therapeutic targets. endocannabinoid system (ECS) lipid signalling...
Although new drugs are being developed for cancer treatment, classical chemotherapeutic agents still front-line therapies, despite their frequent association with severe side effects that can hamper use. Cannabinoids may prevent or palliate some of these effects. The aim the present study is to review basic research which has been conducted evaluating cannabinoid in treatment three important induced by agents: nausea and vomiting, neuropathic pain cognitive impairment. Several published...
Abstract Adult animals submitted to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day 9–10] show behavioral alterations that resemble specific symptoms schizophrenia. Accordingly, this experimental procedure has been proposed as an animal model schizophrenia based on the neurodevelopmental hypothesis. We have recently reported MD‐induced sex‐dependent in hippocampus neonatal rats. In view recent evidence for important implications cerebellum psychiatric diseases,...
Ecstasy is a drug that usually consumed by young people at the weekends and frequently, in combination with cannabis.In present study we have investigated long-term effects of administering increasing doses delta-9tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or conjunction 3,4-methylenedioxymethamphetamine [MDMA; two daily mg/kg every 5 days; s.c.] pnd 30 both male female Wistar rats.When tested one after end pharmacological treatment (pnd...
Peroxisome proliferator-activated receptors (PPARs) are nuclear with three isoforms (PPARα, PPARβ/δ, PPARγ) and can regulate pain, anxiety, cognition. However, their role in conditioned fear pain-fear interactions has not yet been investigated. Here, we investigated the effects of systemically administered PPAR antagonists on formalin-evoked nociceptive behaviour, fear-conditioned analgesia (FCA), presence tone rats. Twenty-three a half hours following conditioning to context, male...