A5002048250- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Health Policy Implementation Science
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Meta-analysis and systematic reviews
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Pain Management Techniques
- Neuroscience and Neuropharmacology Research
- Ethics in Clinical Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Delphi Technique in Research
- Pharmacological Effects of Natural Compounds
- Pharmacological Receptor Mechanisms and Effects
- Mental Health and Patient Involvement
- Veterinary Pharmacology and Anesthesia
- Phosphodiesterase function and regulation
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Neonatal and fetal brain pathology
- Clinical practice guidelines implementation
- Participatory Visual Research Methods
- Heart Rate Variability and Autonomic Control
- Cancer, Stress, Anesthesia, and Immune Response
Ostschweizer Kinderspital
2024
Ollscoil na Gaillimhe – University of Galway
2014-2023
Trials Methodology Research Network
2022
University of Staffordshire
2022
University of Calgary
2016-2021
National University of Ireland
2019
Therapeutics Clinical Research
2015
<ns3:p>Background The Rapid Evidence Support System Assessment (RESSA) was developed by the Global Commission to evaluate evidence support systems that inform policy decisions. These are designed contextualize existing evidence, guide decision-making, and generate new insights action. As evidence-informed policymaking gains traction globally, it is essential these systems’ effectiveness. In Ireland, Health Research Board, Department of Health, Synthesis Cochrane collaborating conduct a RESSA...
Public and patient involvement aims to improve research quality, relevance, appropriateness. Despite an increasing evidence base on the influence of public in health research, role methodology (i.e. that enhance quality rigour research) is less clear. Using a qualitative case study, we explored priority-setting partnership rapid review (Priority III) give practical insights inform for future methodological research.Participant observation, documentary analysis, interviews focus groups were...
The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability poor treatment response. This study examined nociceptive responding mechanical thermal stimuli prior following L5‐L6 spinal nerve ligation ( SNL ), model neuropathic pain, in olfactory bulbectomized OB ) rat depression. Associated changes expression genes encoding for markers glial activation cytokines were subsequently amygdala, key brain...
Abstract All children experience pain, and although many recover quickly, some go on to develop chronic pain. Adolescent pain is a growing epidemic. It unknown why adolescents without incident others persistent Although unexplored, early life adversity may contribute the development maintenance of This study investigated effects underlying neurobiological mechanisms an stressor nociceptive (pain) sensitivity emotional function in male female Sprague‐Dawley rats. Using maternal separation...
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside lack effective treatments, there a great deficit availability objective diagnostic methods to reliably facilitate an accurate diagnosis. We therefore aimed determine feasibility simple test by analysing differentially expressed genes blood patients diagnosed with CNP lower back and compared healthy human controls. Refinement microarray expression data was performed using...
Abstract Opioids are potent analgesics, but their pain‐relieving effects diminish with repeated use. The reduction in analgesic potency is a hallmark of opioid tolerance, which hampers pain therapy. In the central nervous system, analgesia critically modulated by adenosine, purine nucleoside implicated beneficial and detrimental actions medications. Here, we focus on A 3 adenosine receptor (A AR) tolerance. Intrathecal administration AR agonist MRS5698 daily systemic morphine male rats...
On the 11
Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and functional kappa-opioid antagonist, with samidorphan, is being developed as an adjunct therapy for major depressive disorder, in order to harness the mood-enhancing effects opioids without unwanted side-effects such risk addiction. Acute subacute administration buprenorphine samidorphan effective reducing forced swim immobility Wistar-Kyoto rat, but chronic have not been examined. Aims methods: purpose...