A5046420703- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Nerve injury and regeneration
- Cannabis and Cannabinoid Research
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Neuropeptides and Animal Physiology
- Molecular Sensors and Ion Detection
- Pharmacological Receptor Mechanisms and Effects
- Mindfulness and Compassion Interventions
Ollscoil na Gaillimhe – University of Galway
2018-2023
University Hospital Galway
2023
University of Alberta
2014-2016
Introduction Chronic pain is often associated with comorbid anxiety and cognitive dysfunction, negatively affecting therapeutic outcomes. The influence of genetic background on such interactions poorly understood. stress-hyperresponsive Wistar–Kyoto (WKY) rat strain, which models aspects depression, displays enhanced sensitivity to noxious stimuli impaired function, compared Sprague–Dawley (SD) counterparts. However, pain- anxiety-related behaviors impairment following induction a persistent...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPARα, PPARβ/δ and PPARγ. Studies suggest the PPAR signalling system may modulate pain, anxiety cognition. The aim of present study was to investigate whether endogenous via PPARs differentially modulates innate responses mnemonic function presence absence inflammatory pain. We examined effects intraperitoneal administration GW6471 (PPARα antagonist), GSK0660 (PPARβ/δ...
Chronic pain is often comorbid with anxiety and depression, altering the level of perceived pain, which negatively affects therapeutic outcomes. The role endogenous mu-opioid receptor (MOP) system in pain-negative affect interactions influence genetic background thereon are poorly understood. inbred Wistar-Kyoto (WKY) rat, mimics aspects displays increased sensitivity (hyperalgesia) to noxious stimuli, compared Sprague-Dawley (SD) rats. Here, we report that WKY rats hyporesponsive...