A5013551361- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Gut microbiota and health
- Optimism, Hope, and Well-being
- Amino Acid Enzymes and Metabolism
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Metabolism and Genetic Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Lanthanide and Transition Metal Complexes
- Neuroscience and Neuropharmacology Research
- Medicinal Plants and Bioactive Compounds
- Apelin-related biomedical research
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Advanced Fluorescence Microscopy Techniques
- Resilience and Mental Health
- Childhood Cancer Survivors' Quality of Life
- Adipose Tissue and Metabolism
- Cell Image Analysis Techniques
- Memory and Neural Mechanisms
- Neurological and metabolic disorders
Université Laval
2019-2025
Zero to Three
2023
Icahn School of Medicine at Mount Sinai
2022
Hôpital Louis-H Lafontaine
2022
Douglas Mental Health University Institute
2022
Allen Institute for Brain Science
2022
Trinity College Dublin
2022
McGill University
2022
Sorbonne Université
2022
Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly...
Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with symptoms in male mice; however, this association unclear females. Here, we report chronic social subchronic variable stress promotes blood-brain barrier (BBB) alterations mood-related brain regions female mice. Targeted disruption the BBB prefrontal cortex (PFC) induces anxiety- depression-like behaviours. By...
Abstract Proper cerebrovascular development and neurogliovascular unit assembly are essential for brain growth function throughout life, ensuring the continuous supply of nutrients oxygen. This involves crucial events during pre- postnatal stages through key pathways, including vascular endothelial factor (VEGF) Wnt signaling. These pathways pivotal growth, expansion, blood–brain barrier (BBB) maturation. Interestingly, fetal neonatal formation coincides with early peak activity...
<title>Abstract</title> Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure preventive strategies them remain poorly understood. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety-...
Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic...
Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity; still, little known about intestinal function these conditions, particularly for small intestine, where absorption most foods and drugs takes place.
<title>Abstract</title> Major depressive disorder (MDD) is a leading cause of disease burden worldwide with low therapeutic efficacy. The blood-brain barrier (BBB) essential to maintain brain homeostasis and regulate drug delivery. Chronic social stress, MDD’s main environmental risk factor, associated neurovascular pathology in mice including loss BBB integrity mood-regulating regions sex-specific manner, which also observed individuals MDD. Pericytes ensheathe endothelial cells modulate...
Experiences are linked to emotions impacting memory consolidation and associated brain neuronal circuits. Posttraumatic stress disorder is an example of strong negative affecting processes by flashbacks past traumas. Stress-related deficits also observed in major depressive (MDD). We recently highlighted that sex-specific blood-brain barrier (BBB) alterations underlie responses mice human depression. However, little known about the relationship between emotional valence, encoding BBB gene...
Abstract Background Chronic social defeat stress is a widely used depression model in male mice. Several proposed adaptations extend this to females with variable, often marginal effects. We examine the if male-defined metrics of are suboptimal and reveal sex-specific adaptations. Methods Using data-driven method we comprehensively classified interaction behavior 761 female mice after chronic witness/defeat stress, examining modulation behavioral frequencies associations conventional (i.e.,...
Abstract Blood-brain barrier (BBB) alterations contribute to stress vulnerability and development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unexplored. Here, we report that high expression astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly endfeet ensheathing blood vessels, is associated with despite chronic social exposure. Viral-mediated overexpression Cnr1 astrocytes NAc shell has baseline...
Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure remain undetermined. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety- depression-like behaviors mice via an increase fibroblast growth...
FIGURE S1: Macroscopic examination of the posterior brain. S2: Specific histochemical and immunohistochemical stainings performed on mid-sagittal sections from patient's cerebellum at level middle cerebellar peduncle. S3: White matter vacuolar changes. S4: Representative staining post-mortem white parietal lobe. S5: Additional nuclei in CNS tissues ADLD patient. Table Clinical information autopsy cases Please note: The publisher is not responsible for content or functionality any supporting...
Abstract Major depressive disorder (MDD) is the leading cause of disability worldwide. However, 30-50% patients are unresponsive to commonly prescribed antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis, bidirectional communications between central nervous system and gastrointestinal tract that modulated by gut microorganisms, has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity, still,...
Prevalence, symptoms, and treatment of depression all point toward major sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice however it remains unknown if contributes to this sexual dimorphism. Here, we report that chronic social subchronic variable stress promoted sex-specific blood-brain barrier (BBB) molecular morphological alterations mood-related brain regions. Viral-mediated functional manipulation leading a targeted...