A5065231626- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
- Schizophrenia research and treatment
- Dermatology and Skin Diseases
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Glycosylation and Glycoproteins Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Calcium signaling and nucleotide metabolism
- Single-cell and spatial transcriptomics
- Chemical synthesis and alkaloids
- Chronic Lymphocytic Leukemia Research
- Toxin Mechanisms and Immunotoxins
- Immunotoxicology and immune responses
- Forensic Toxicology and Drug Analysis
Institut Universitaire en Santé Mentale de Québec
2013-2025
Université de Montréal
2005-2023
Hôpital Louis-H Lafontaine
2011-2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2017
Douglas Mental Health University Institute
2017
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2017
Hôpital Maisonneuve-Rosemont
1995-2012
Faculty (United Kingdom)
2011
Institut National de la Recherche Scientifique
2001-2004
McGill University
2004
Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with symptoms in male mice; however, this association unclear females. Here, we report chronic social subchronic variable stress promotes blood-brain barrier (BBB) alterations mood-related brain regions female mice. Targeted disruption the BBB prefrontal cortex (PFC) induces anxiety- depression-like behaviours. By...
ABSTRACT Objectives Beyond male/female binaries, gender roles represent masculine and feminine traits that we assimilate enact throughout life span development. Bem proposed “androgynous” individuals adeptly adapt to different contexts by alternating from a strong repertoire of both roles. By contrast, “undifferentiated” may not as well social norms because weak self-endorsed masculinity femininity. Methods Among 204 adults (mean [standard error] age = 40.4 [0.9] years; 70% women) working in...
Abstract A new gas chromatographic method was developed for the quantification of levamisole in human plasma and urine, using a nitrogen–phosphorus flame ionization detector. The adsorption drug onto glass prevented by treating glassware with siliconizing agent. sensitivity assay 10 ng ml −1 as low 2 can be detected plasma. urinary metabolite p ‐hydroxylevamisole analysed high performance liquid chromatography ultraviolet detection. this 0·50 μg . Plasma concentrations were determined...
Mirtazapine promotes sleep by blocking serotonin and histaminergic receptors is often used off-label to treat chronic insomnia. However, its efficacy remains be demonstrated in a clinical trial. The MIRAGE study aims determine the safety of mirtazapine older patients with This was double-blind, randomised, placebo-controlled trial geriatric outpatient clinic teaching hospital. Adults aged 65 years insomnia were included. Sixty participants randomised 1:1 ratio receive 7.5 mg or matching...
The pre‐ and postsynaptic effects of zimelidine norzimelidine were studied in adult male Sprague‐Dawley rats. potency the presynaptic effect was estimated from their ability to depress rate firing serotonin (5‐HT)‐containing raphe neurons. Chronic administration tricyclic antidepressant drugs has been shown sensitize forebrain 5‐HT receptors. on these receptors compared that saline chlorimipramine by assessing responsiveness hippocampal pyramidal cells microiontophoretic applications 5‐HT,...
In 2008, the National Institute of Mental Health (NIMH) announced that in next few decades, it will be essential to study various biological, psychological and social "signatures" mental disorders. Along with this new "signature" approach health disorders, modifications DSM were introduced. One major modification consisted incorporating a dimensional which involved analyzing, using transnosological approach, factors are commonly observed across different types Although methodology led...
Serotonin (5-HT) up-regulates B and T lymphocyte proliferation by activating mitogen-induced cell surface 5-HT1A receptors. The mechanism of 5-HT1Areceptor induction mitogens at the mRNA protein levels in mouse splenocytes was addressed. Quantitation RNase protection assay showed maximal increases 3.4-, 3.0-, 3.8-, 4.9-fold relative after 48 h stimulation with lipopolysaccharide, phytohemagglutinin, concanavalin A, or phorbol 12-myristate 13-acetate plus ionomycin, respectively, as compared...
Cardiotoxicity has become a major concern during treatment with antimalarial drugs. Lengthening of the QTc and severe cardiac arrhythmia have been observed, particularly after halofantrine for chloroquine-resistant Plasmodium falciparum malaria. The purpose this prospective study was to evaluate whether agents alter dispersion ventricular repolarization dynamicity. Sixty patients uncomplicated malaria were randomly allocated in four groups 15 treated quinine, mefloquine, artemether, or at...
Disturbances in the endogenous cannabinoid (ECB) system schizophrenia may contribute to their enhanced sensitivity psychoactive substances, and beneficial effects of second-generation antipsychotics for substance abuse involve modulatory on ECB. To verify these two assumptions, 29 patients (24 completers) with use disorders (SUD) were treated quetiapine 12 weeks, peripheral ECB levels measured, using high-performance liquid chromatography/mass spectrometry, (weeks 0, 6 12) 17 healthy...
Objective Fibromyalgia and major depressive disorder (MDD) frequently co‐occur. Quetiapine fumarate extended‐release (quetiapine XR) has demonstrated efficacy in the treatment of MDD been shown to have analgesic properties patients with depression. The primary objectives this study were evaluate effects quetiapine XR on pain symptoms comorbid fibromyalgia, assess its safety tolerability. Methods This was an 8‐week, single‐center, double‐blind, randomized, controlled trial. A total 120...
Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity; still, little known about intestinal function these conditions, particularly for small intestine, where absorption most foods and drugs takes place.
Fas (CD95), a member of the tumor necrosis factor-receptor superfamily, has been studied extensively as death-inducing receptor in immune system. However, is also widely expressed number other tissues, including neurons. Here, we report that defects Fas/Fas ligand system unexpectedly render mice highly susceptible to neural degeneration model Parkinson's disease. We found Fas-deficient lymphoproliferative develop dramatic phenotype resembling clinical disease, characterized by extensive...
Schizophrenia is a complex psychiatric disorder strongly associated with substance use disorders. Theoretically, schizophrenia and SUD may share endocannabinoid alterations in the brain reward system. The main endocannabinoids, anandamide, 2-arachidonoylglycerol, are lipids which bind cannabinoid receptors. Oleoylethanolamide (OEA), fatty-acid ethanolamide, binds peroxisome proliferator-activated system has been shown to be impaired schizophrenia, recently, our group that patients have...
AbstractThe effects of some dopaminergic antagonists were investigated on mouse lymphocyte proliferative responses in vitro. The mixed D1/D2 chlorpromazine, haloperidol and fIupentixol inhibited 3H-Thymidine incorporation into adult BALB/c spleen cells stimulated by concanavalin A, lipopolysaccharide from Escherichia coli, allogenic a reaction. inhibition was achieved at concentrations greater than 10−6M. It not accounted for decreased cell viability it no longer demonstrable when the...
Objective: To assess the relationship between Screen for Cognitive Impairment in Psychiatry (SCIP) score and illness severity, subjective cognition functioning a cohort of major depressive disorder (MDD) patients.Methods: Patients (n = 40) diagnosed with MDD (DSM-IV-TR) completed SCIP, brief neuropsychological test, battery self-administered questionnaires evaluating (GAF, SDS, WHODAS 2.0, EDEC, PDQ-D5). Disease severity was evaluated Hamilton Depression Rating Scale (HDRS) Clinical Global...