A5087528342- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Gut microbiota and health
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Neurological and metabolic disorders
- Herpesvirus Infections and Treatments
- Medicinal Plants and Bioactive Compounds
- interferon and immune responses
- Immune Response and Inflammation
- Cancer, Stress, Anesthesia, and Immune Response
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Optimism, Hope, and Well-being
- Neurological disorders and treatments
- Nerve injury and regeneration
- Obstructive Sleep Apnea Research
- Transcranial Magnetic Stimulation Studies
- Phagocytosis and Immune Regulation
Université Laval
2016-2025
Lou Ruvo Brain Institute
2020-2024
Icahn School of Medicine at Mount Sinai
2022
Trinity College Dublin
2022
Douglas Mental Health University Institute
2022
Hôpital Louis-H Lafontaine
2022
McGill University
2022
Allen Institute for Brain Science
2022
Sorbonne Université
2022
Wilfrid Laurier University
2017
Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly...
Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with symptoms in male mice; however, this association unclear females. Here, we report chronic social subchronic variable stress promotes blood-brain barrier (BBB) alterations mood-related brain regions female mice. Targeted disruption the BBB prefrontal cortex (PFC) induces anxiety- depression-like behaviours. By...
The signals that regulate the fate of circulating monocytes remain unknown. In present study, we demonstrate triggering NOD2 receptor by muramyl dipeptide (MDP) converts inflammatory Ly6Chigh into patrolling Ly6Clow monocytes. Administration MDP to Nr4a1-/- mice, which lack monocytes, or Ly6Clow-depleted mice led emergence blood-patrolling with a profile similar including high expression CX3CR1 and LFA1. Using intravital microscopy in animal models diseases, also found converted patrol...
<title>Abstract</title> Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure preventive strategies them remain poorly understood. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety-...
Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic...
Monocytes are central to the physiopathology of arthritis, but their roles in progression and resolution disease remain be clarified. Using NR4A1 −/− mice, which lack patrolling lymphocyte antigen 6C (Ly6C low ) monocytes, we found that inflammatory Ly6C high monocytes contribute rapid development arthritis a serum transfer‐induced (STIA) model. Our experiments suggest do not promote initiation as severity symptoms was amplified mice. Moreover, show treatment arthritic wild type (WT) mice...
Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity; still, little known about intestinal function these conditions, particularly for small intestine, where absorption most foods and drugs takes place.
Toll-like receptors (TLRs) and RNA helicases (RLHs) are important cell sensors involved in the immunological control of viral infections through production type I interferon (IFN). The impact a deficiency TRIF IPS-1 adaptor proteins, respectively, implicated TLR3 RLH signaling pathways, was investigated during herpes simplex virus 1 (HSV-1) encephalitis. TRIF(-/-), IPS-1(-/-), C57BL/6 wild-type (WT) mice were infected intranasally with 7.5 × 10(5) PFU HSV-1. Mice monitored for neurological...
<title>Abstract</title> Major depressive disorder (MDD) is a leading cause of disease burden worldwide with low therapeutic efficacy. The blood-brain barrier (BBB) essential to maintain brain homeostasis and regulate drug delivery. Chronic social stress, MDD’s main environmental risk factor, associated neurovascular pathology in mice including loss BBB integrity mood-regulating regions sex-specific manner, which also observed individuals MDD. Pericytes ensheathe endothelial cells modulate...
Experiences are linked to emotions impacting memory consolidation and associated brain neuronal circuits. Posttraumatic stress disorder is an example of strong negative affecting processes by flashbacks past traumas. Stress-related deficits also observed in major depressive (MDD). We recently highlighted that sex-specific blood-brain barrier (BBB) alterations underlie responses mice human depression. However, little known about the relationship between emotional valence, encoding BBB gene...
Moral injuries can occur when perpetrating, failing to prevent, or bearing witness acts that transgress deeply held moral beliefs and expectations. The COVID-19 crisis highlighted the fact psychosocial stressors at work, such as high emotional demands, are placing Canadian healthcare workers risk of injuries. Evidence linking work needed better predict, prevent manage injuries, these frequent modifiable occupational factors. This protocol presents a study aiming to: 1) understand workplace...