A5054985515- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Osteoarthritis Treatment and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Global Health Care Issues
- Extracellular vesicles in disease
- Optimism, Hope, and Well-being
- Pharmacological Receptor Mechanisms and Effects
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neurological and metabolic disorders
- Intracranial Aneurysms: Treatment and Complications
- Resilience and Mental Health
- Waste Management and Environmental Impact
Université Laval
2019-2025
Zero to Three
2023
Sorbonne Université
2022
Allen Institute for Brain Science
2022
Hôpital Louis-H Lafontaine
2022
Trinity College Dublin
2022
Douglas Mental Health University Institute
2022
McGill University
2022
Icahn School of Medicine at Mount Sinai
2022
University of Agriculture in Krakow
2014-2020
MicroRNA (miRNA) biomarkers are attracting considerable interest. Effects of medication, however, have not been investigated thus far.
Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly...
Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with symptoms in male mice; however, this association unclear females. Here, we report chronic social subchronic variable stress promotes blood-brain barrier (BBB) alterations mood-related brain regions female mice. Targeted disruption the BBB prefrontal cortex (PFC) induces anxiety- depression-like behaviours. By...
Articular cartilage enables weight bearing and near friction-free movement in the joints. Critical to its function is production of a specialized, mechanocompetent extracellular matrix controlled by master regulator transcription factor SOX9. Mutations SOX9 cause campomelic dysplasia, haploinsufficiency disorder resulting severe skeletal defects dwarfism. Although much understood about how regulates synthesis hence joint function, this itself regulated remains largely unknown. Here we...
Rationale: Platelets shed microRNAs (miRNAs). Plasma miRNAs change on platelet inhibition. It is unclear whether plasma miRNA levels correlate with function. Objective: To link small RNAs to reactivity. Methods and Results: Next-generation sequencing of in revealed 2 peaks at 22 23 32 33 nucleotides corresponding YRNAs, respectively. Among predominantly, fragments RNY4 RNY5 were detected. YRNAs measured 125 patients a history acute coronary syndrome who had undergone detailed assessment...
miRNAs have been shown to be essential for normal cartilage development in the mouse. However, role of specific function is unknown. Using rarely available healthy human chondrocytes (obtained from 8 50 year old patients), we detected a most highly abundant primary miRNA H19, whose expression was heavily dependent on master regulator SOX9. Across range murine tissues, both H19- and H19-derived miR-675 mirrored that cartilage-specific up-regulate matrix component COL2A1, overexpression...
To determine the effects of hypoxia on both anabolic and catabolic pathways metabolism in human articular cartilage to elucidate roles played by hypoxia-inducible factors (HIFs) these responses.Normal from a range donors was obtained at time above-the-knee amputations due sarcomas not involving joint space. Fresh tissue explants isolated cells were subjected treatment with interleukin-1α. Cell transfections performed chondrocytes.Using chromatin immunoprecipitation, we found that induced...
<title>Abstract</title> Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure preventive strategies them remain poorly understood. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety-...
Blood–brain barrier (BBB) alterations contribute to stress vulnerability and the development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unclear. Here we report that high expression astrocytic cannabinoid receptor 1 (CB1) in nucleus accumbens (NAc) shell, particularly end-feet ensheathing blood vessels, is associated with during chronic social adult male mice. Viral-mediated overexpression Cnr1 astrocytes NAc shell results baseline anxiolytic...
Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity; still, little known about intestinal function these conditions, particularly for small intestine, where absorption most foods and drugs takes place.
Abstract Cultivation of seedlings in trays requires the use specifically developed substrates. This study presents results analyses selected physical and mechanical parameters a peat–perlite substrate, which Scots pine ( Pinus sylvestris L.), Norway spruce Picea abies (L.) H. Karst), European beech Fagus sylvatica pedunculate oak Quercus robur L.) were grown during production season. For each species, substrate changed throughout season, dry weight decreased, whereas its compactness...
Abstract Blood-brain barrier (BBB) alterations contribute to stress vulnerability and development of depressive behaviors. In contrast, neurovascular adaptations underlying resilience remain unexplored. Here, we report that high expression astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly endfeet ensheathing blood vessels, is associated with despite chronic social exposure. Viral-mediated overexpression Cnr1 astrocytes NAc shell has baseline...
Abstract Opioids are effective analgesics in the management of severe pain. However, tolerance, leading to dose escalation and adverse effects significant limiting factors their use. The role peripheral opioid receptors analgesia has been discussed especially under inflammatory conditions. results from pharmacological conditional knockout studies together do not provide a clear picture contribution on antinociceptive tolerance this needs be evaluated. Therefore, we studied whether...
Abstract Dieback of Norway spruce (Picea abies (L.) H. Karst) which has been observed in the Western Carpathians is interest to scientists from many disciplines.. The aim this study was determine impact deforestation on water chemical composition mountainous streams and springs. research carried out 2004 2013 two catchments Skrzyczne massif Silesian Beskid Mountains. Field studies included measurements pH conductivity. Under laboratory conditions, there were determined concentrations: Na + ,...
Chronic stress can promote loss of blood-brain barrier (BBB) integrity leading to passage circulating inflammatory mediators in mood-regulating brain areas and establishment depressive behaviors. Conversely, neurovascular adaptations favoring resilience exposure remain undetermined. Here, we report that environmental enrichment dampens stress-induced endothelial tight junction protein Claudin-5 (Cldn5) along with anxiety- depression-like behaviors mice via an increase fibroblast growth...
Abstract Major depressive disorder (MDD) is the leading cause of disability worldwide. However, 30-50% patients are unresponsive to commonly prescribed antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in microbiota-gut-brain axis, bidirectional communications between central nervous system and gastrointestinal tract that modulated by gut microorganisms, has been implicated MDD pathogenesis. Exposure chronic stress disrupts blood-brain barrier integrity, still,...