A5059891713- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Dietary Effects on Health
- Meat and Animal Product Quality
- Engine and Fuel Emissions
- Reproductive System and Pregnancy
- Hypothalamic control of reproductive hormones
- Animal Nutrition and Physiology
- Estrogen and related hormone effects
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Cytokine Signaling Pathways and Interactions
- Fatty Acid Research and Health
- Animal Behavior and Welfare Studies
- Cancer-related molecular mechanisms research
- Mechanical and Thermal Properties Analysis
- Medicinal Plant Pharmacodynamics Research
- Neurobiology and Insect Physiology Research
- Birth, Development, and Health
University of Agriculture in Krakow
2015-2024
University of Agriculture Faisalabad
2010
The adaptation of the physiology an animal to changing conditions light and food availability is evident at behavioral hormonal levels. Melatonin, leptin, ghrelin, orexin, which exhibit rhythmic secretion profiles under ad libitum feeding conditions, are sensitive changes in daylength, forming a tight web interrelationships regulation energy balance. aim this study was determine effects central injections orexin on reciprocal interactions among these hormones influence photoperiod responses....
Decreased growth hormone (GH) function in obese patients might contribute to associated metabolic abnormalities. This study aimed investigate the effect of leptin, GH and periods leptin sensitivity or/and insensitivity on expression SOCS-3 gene ovine pituitary examine influence centrally administered release sheep. Our first experiment investigated resistance sensitivity, which are known as long day (LD) short (SD) periods, respectively, using ewes that were surgically fitted with third...
We hypothesized that resistin is engaged in the development of leptin central insensitivity/resistance sheep, which a unique animal model to explore reversible resistance. Thirty Polish Longwool ewes, were ovariectomized with estrogen replacement, used. Treatments consisted intravenous injection control (saline) or recombinant bovine (rbresistin): (Control; n = 10), low dose rbresistin (R1; 1.0 μg/kg body weight (BW); and high (R2; 10.0 BW; 10). The studies performed during short-day (SD)...
Both long-term undernutrition and overnutrition disturb metabolic balance, which is mediated partially by the action of two adipokines, leptin resistin (RSTN). In this study, we manipulated diet ewes to produce either a thin (lean) or fat (fat) body condition investigated how RSTN affects endocrine status under different concentrations. Twenty were distributed into four groups (n = 5): lean administered with saline (Lean Fat), while Lean-R (Lean-Resistin treated) Fat-R (Fat-Resistin received...
The short form of the leptin receptor (LeptRa) plays a key role in transport to central nervous system (CNS). Here, MTS-leptin and recombinant ovine (ro) leptin-mediated expression LeptRa VEGFA VEGFR2 concentration selected hypothalamic nuclei, choroid plexus (ChP), anterior pituitary (AP) were analyzed considering photoperiod acute-fasting (experiment 1), nutritional status 2) ewes. In experiment 1, 60 sheep fed normally or fasted for 72 h received one injection saline, MTS-leptin, roleptin...
Abstract The aim of this study was to analyse changes in the abundance prolactin (PRL) receptor (PRLR) and suppressor cytokine signalling‐3 (SOCS‐3) mRNA ventro‐/dorsomedial nucleus (VMH/DMH) arcuate (ARC) hypothalamus as well median eminence (ME) adenohypophysis (AP) sheep at 30, 60, 90 120 d pregnancy compared non‐pregnant animals. In VMH/DMH, PRLR transcripts were detected only ewes. ARC, abundances higher pregnant on days 30 ( p < .01), .01) .05) than sheep. contrast, expression ME...
Abstract The influence of leptin on orexin A and the interaction with ghrelin in regulating gonadotropic somatotropic axes seasonally polyestrous animals are not well understood. This study examined effects these factors as mediating roles specific ovine antagonist (SOLA; mutant D23L/L39A/D40A/F41A) photoperiod luteinizing hormone (LH) growth (GH) secretion. Twenty-four ovariectomized, estradiol-implanted ewes were used a replicated switchback design. assigned randomly to 1 6 treatments...
The effects of hyperleptinemia and leptin resistance during gestation are unclear. Leptin, an important neuroendocrine regulator, has anorexic effects, but its interactions with other metabolic hormones pregnancy We examined potential roles in regulating prolactin (PRL), GH, melatonin plasma concentrations Polish Longwool ewes. Twelve estrus-synchronized ewes carrying twins after mating were randomly assigned to receive i.v. injections saline or recombinant ovine (2.5 5.0 µg/kg BW). Blood...
Recent studies confirmed that pineal melatonin (MEL) secretion is regulated by ghrelin (GHRL) in seasonally reproductive sheep. The first vivo experiment investigated whether the effect of GHRL on nocturnal MEL sheep mediated type 2 serotonin receptors. Sheep ( = 16) were intravenously injected with (2.5 μg/kg BW) and meta-Chlorophenylpiperazine (mCPP; a mixed agonist 5-HT2B/5-HT2C receptors; 1 mg/kg BW), either combined or individually, during short-day (SDS) long-day (LDS) seasons. Blood...
This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, day length on suppressor cytokine signaling-3 (SOCS-3) mRNA levels in adenohypophyses sheep. The consisted two experiments. first experiment was conducted during long (LD) short (SD) days. Within-season replicate sheep were centrally infused with Ringer-Locke buffer or three times at 60-min intervals beginning second involved collected from that euthanized May November. Pituitary...
The short form of the leptin receptor (LRa) plays a key role in transport to central nervous system (CNS). Here, resistin (RSTN)-mediated expression LRa preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus (ARC) anterior pituitary gland (AP)was analyzed considering photoperiodic (experiment 1) nutritional status 2) ewes. In experiment 1, 30 sheep were fed normally received one injection saline or two doses RSTN hour prior euthanasia. increased mainly ARC AP...
Several studies suggests that ghrelin (GHRL) has neurobiological effects extend beyond control of food intake. Our previous results confirmed GHRL modulates the secretory activity pineal gland (PG) through nocturnal melatonin (MEL) secretion in sheep, seasonally reproductive animals. Here we investigated (10 ng/ml) on expression enzymes limiting synthesis MEL, including tryptophan 5-hydroxylase 1 (TPH1), serotonin N-acetyltransferase (AA-NAT) and its phosphorylated form p31T-AA-NAT sheep PG...
Recent studies confirmed that pineal melatonin (MEL) secretion is regulated by ghrelin (GHRL) in seasonally reproductive sheep. The first vivo experiment investigated whether the effect of GHRL on nocturnal MEL sheep mediated type 2 serotonin receptors. Sheep (n = 16) were intravenously injected with (2.5 μg/kg BW) and meta-Chlorophenylpiperazine (mCPP; a mixed agonist 5-HT2B/5-HT2C receptors; 1 mg/kg BW), either combined or individually, during short-day (SDS) long-day (LDS) seasons. Blood...