A5039545070- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Infective Endocarditis Diagnosis and Management
- Social Media in Health Education
- Pleural and Pulmonary Diseases
- Circular RNAs in diseases
- Artificial Intelligence in Healthcare and Education
- Trauma Management and Diagnosis
- Adrenal Hormones and Disorders
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Simulation-Based Education in Healthcare
- IL-33, ST2, and ILC Pathways
- Cardiac Imaging and Diagnostics
NIHR Bristol Cardiovascular Biomedical Research Unit
2021-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2022-2023
University of Bristol
2022-2023
University Hospitals Bristol NHS Foundation Trust
2022-2023
University of Auckland
2022
King's College Hospital
2014-2020
King's College Hospital NHS Foundation Trust
2016-2019
King's College London
2015-2019
NIHR Imperial Biomedical Research Centre
2019
Imperial College London
2019
Rationale: Platelets shed microRNAs (miRNAs). Plasma miRNAs change on platelet inhibition. It is unclear whether plasma miRNA levels correlate with function. Objective: To link small RNAs to reactivity. Methods and Results: Next-generation sequencing of in revealed 2 peaks at 22 23 32 33 nucleotides corresponding YRNAs, respectively. Among predominantly, fragments RNY4 RNY5 were detected. YRNAs measured 125 patients a history acute coronary syndrome who had undergone detailed assessment...
YouTube is a highly utilized Web site that contains large amount of medical educational material. Although some studies have assessed the education material contained on site, little analysis cardiology content has been made. This study aimed to assess quality videos relating heart sounds and murmurs YouTube.We hypothesized video files purporting provide auscultation would be variable.Videos were searched for using terms "heart sounds," murmur," auscultation." A built-in filter was employed,...
Background: Although electronic health records (EHR) provide useful insights into disease patterns and patient treatment optimisation, their reliance on unstructured data presents a difficulty. Echocardiography reports, which extensive pathology information for cardiovascular patients, are particularly challenging to extract analyse, because of narrative structure. natural language processing (NLP) has been utilised successfully in variety medical fields, it is not commonly used...
Hypertension is associated with heightened cardiac sympathetic drive whilst statins reduce angiotensin II (ATII) signalling, superoxide anion production and increase nitric oxide bioavailability, events that can potentially peripheral neurotransmission. We therefore investigated whether pravastatin alters control in the spontaneously hypertensive rat (SHR). SHRs (16-18 weeks) had significantly (p<0.05) enhanced atrial (3)H-norepinephrine ((3)H-NE) release to field stimulation compared...
Large-scale implantable cardioverter defibrillator (ICD) trials have unequivocally shown a reduction in mortality appropriately selected patients with heart failure and depressed left ventricular function. However, there is strong association between shocks increased ICD recipients. It unclear if are merely marker of more severe cardiovascular disease or directly contribute to the increase mortality. The aim this review examine relationship mortality, explore possible mechanisms. Data...
YouTube contains a large volume of medical educational material. This study assessed the quality respiratory auscultation videos contained in YouTube. Videos were searched for using terms 'breath sounds', 'respiratory auscultation' and/or 'lung sounds'. In total, 6,022 located, 36 which considered suitable scoring video accuracy, comprehensiveness and quality. The average score was 3.32/6 (55.3% ± 1.30). Video correlated with time-adjusted metadata: hits per day (0.496, p=0.002) likes...
ST2 is a circulating biomarker that well established for predicting outcome in heart failure (HF). This the first study to look at concentrations optimally treated patients with stable but significant left ventricular systolic dysfunction (LVSD) compared severe aortic stenosis (AS).Two cohorts were retrospectively studied: 94 undergoing transcatheter valve implantation AS (63 normal ejection fraction [EF] and 31 reduced EF), 50 LVSD from non-valvular causes. pre-procedural samples taken,...
Abstract Background The Gerbode defect is a rare abnormal communication between the left ventricle (LV) and right atrium (RA). lesion either congenital or acquired. Acquired defects are largely iatrogenic infective in origin. We present two cases of acquired with similar clinical presentations but very different outcomes. Case summaries Patient 1 A 64-year-old male presented features decompensated cardiac failure low-grade temperature. Dehiscence recently implanted bioprosthetic aortic valve...
We aimed to develop a machine learning algorithm predict the presence of culprit lesion in patients with out-of-hospital cardiac arrest (OHCA).We used King's Out-of-Hospital Cardiac Arrest Registry, retrospective cohort 398 admitted College Hospital between May 2012 and December 2017. The primary outcome was coronary artery lesion, for which gradient boosting model optimized predict. then validated two independent European cohorts comprising 568 patients.A observed 209/309 (67.4%) receiving...
Background: Out-of-hospital cardiac arrest (OHCA) is associated with very poor clinical outcomes. An optimal pathway of care yet to be defined, but prognostication likely assist in the challenging decision-making required for treatment this high-risk patient cohort. The MIRACLE2 score provides a simple method neuro-prognostication as it has not been externally validated. aim study was therefore retrospectively apply cohort OHCA patients assess predictive ability and accuracy identification...
Background: 
 Although electronic health records (EHR) provide useful insights into disease patterns and patient treatment optimisation, their reliance on unstructured data presents a difficulty. Because of narrative structure, echocardiography reports, which extensive pathology information for cardiovascular patients, are particularly challenging to extract analyse. natural language processing (NLP) has been utilised successfully in variety medical fields, it is not commonly used...
Introduction: Atrial fibrillation (AF) is the most prevalent cardiac dysrhythmia and percutaneous catheter ablation widely used to treat it. Panoramic mapping with multi-electrode catheters can identify targets in persistent AF, but limited by poor contact inadequate coverage. Objective: To investigate accuracy of inverse endocardial surface potentials from electrograms sampled noncontact basket catheters. Methods: Our group has developed a computationally efficient 3D technique using...