A5064080495- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Breast Implant and Reconstruction
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Thyroid and Parathyroid Surgery
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Genital Health and Disease
- Urinary and Genital Oncology Studies
- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Adrenal Hormones and Disorders
Yale University
2015-2025
University of Louisville
2024
Yale New Haven Hospital
2018-2023
Memorial Sloan Kettering Cancer Center
2013-2022
Geisinger Medical Center
2022
Baylor College of Medicine
2022
University of California San Diego Medical Center
2022
University of California, San Diego
2022
Calgary Laboratory Services
2016-2020
University of Calgary
2016-2020
It has been hypothesized that tumors with high interstitial fluid pressure (IFP) and/or hypoxia respond poorly to chemotherapy (CT) because of poor drug delivery. Preclinical studies have shown paclitaxel reduces the IFP and improves oxygenation (pO(2)) tumors. Our aim is evaluate pO(2) before after neoadjuvant CT using sequential doxorubicin in patients breast cancer >/= 3 cm.Patients were randomly assigned, according an institutional review board-approved phase II protocol, receive...
Context.—Breast cancer is increasingly treated with neoadjuvant chemotherapy to improve surgical resectability and evaluate tumor response, which assessed histopathologically. Several histopathologic classification systems have been previously described for assessment of treatment response. Objectives.—To test performance in a side-by-side comparison several after clinical outcome. Design.—Sixty-two patients were enrolled randomized trial receiving sequential doxorubicin paclitaxel....
Activating point mutations of the RAS gene (NRAS, HRAS, and KRAS) can be seen in benign malignant thyroid tumors; among these, NRAS are more commonly seen. This study was conducted to evaluate risk malignancy (ROM) associated with fine-needle aspiration (FNA) at authors' institution.The authors searched their electronic database system between January 2015 May 2021 for FNA cases any type mutation. Molecular alterations were identified ThyroSeq Genomic Classifier, ThyGeNEXT (thyroid oncogene...
This study aimed to determine whether Ki-67 index evaluated on cytologic material could reliably grade pancreatic neuroendocrine tumors (PanNETs).Cases with adequate cell block and available surgical specimens were included. was calculated using "eyeballing," "hot spot," "complete" counting methods.The overall concordance rates between cytology 71%, 73%, 59%, respectively, by eyeballing, hot spot, complete approaches. All 1 correctly graded cytology, but in 2 only 36%, 41%, 9%, respectively....
Microglandular hyperplasia (MGH) is a benign proliferation of endocervical glands with relatively uniform columnar or cuboidal nuclei, and rare to absent mitoses. Endometrial adenocarcinomas mucinous differentiation microglandular pattern can closely mimic MGH, often resulting in diagnostic dilemma small biopsy specimens. Rare unusual morphologic features-mild moderate nuclear atypia, solid reticular growth pattern, hobnail signet ring cells-have been previously reported MGH. We present 9...
BACKGROUND The fine‐needle aspiration (FNA) diagnosis of thyroid Hürthle cell neoplasms (HCNs) remains challenging. This study explored a possible association copy number variations (CNVs) with lesions the thyroid. METHODS Thyroid FNA cases that were diagnosed as follicular lesion undetermined significance (FLUS) or neoplasm (FN)/HCN for which ThyroSeq version 3 genomic classifier test was performed retrieved. RESULTS A total 324 (228 FLUS cases, 46 HCN and 50 FN cases) included in study....
Background This study investigated p16 by immunohistochemistry (IHC) on cellblocks (CBs) and human papillomavirus (HPV) polymerase chain reaction (PCR) in fine‐needle aspiration (FNA) of head neck squamous cell carcinoma (HNSCC). Methods Receiver operating characteristic (ROC) curve analysis was used to assess test performance CBs compared with IHC 42 surgical specimens from patients HNSCC correlation HPV PCR cytology specimens. The assessed FNA as a substitute for Results Of cases, 38...
Uterine teratomas are a rare entity with debated origin. Given its rarity and limitations of diagnostic imaging, diagnosis is typically determined pathologically following surgical resection based on the presence tissue derived from all germ cell layers. Unlike ovarian counterpart, developmental origins poorly understood; however, recently introduced molecular testing has revolutionized our understanding these tumors.
Context.— Direct visualization of Pneumocystis jiroveci organisms, using Gomori methenamine silver (GMS) staining in bronchoalveolar lavage fluid (BAL), is a historical gold standard that has been widely used for the diagnosis P pneumonia (PJP). However, stain may be less sensitive human immunodeficiency virus (HIV)–negative immunocompromised patients owing to lower burden organisms. Objectives.— To assess sensitivity GMS on BAL PJP HIV-negative as compared HIV-positive patients. Design.— We...
Background Neurotrophic tyrosine kinase receptor ( NTRK ) rearrangement has been reported in a subset of papillary thyroid carcinoma (PTC) cases. Little is known about the cytomorphologic features ‐rearranged PTC. Methods We report an institutional series 13 fine‐needle aspiration (FNA) specimens PTC with predominantly indeterminate cytology diagnosis. NTRK3 or NTRK1 rearrangements were detected on FNA surgical by next‐generation sequencing. Results The patients had median age 18 years; 10...
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy, and early diagnosis, often aided by fine-needle aspiration (FNA), key to improving patient prognosis. While the current literature describes some of cytologic features (CFs) this entity, a comprehensive examination CFs has not yet been performed.