A5077408770- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Electrical and Bioimpedance Tomography
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Ultrasonics and Acoustic Wave Propagation
- Electrochemical Analysis and Applications
- Cardiovascular Function and Risk Factors
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Muscle activation and electromyography studies
- Atrial Fibrillation Management and Outcomes
- Numerical methods in inverse problems
- Non-Invasive Vital Sign Monitoring
- Advanced Electrical Measurement Techniques
- Image and Signal Denoising Methods
- Statistical and numerical algorithms
- Control Systems and Identification
- Magnetic Properties and Applications
- Non-Destructive Testing Techniques
- Probabilistic and Robust Engineering Design
- Model Reduction and Neural Networks
Inserm
2016-2025
Centre de Recherche Cardio-Thoracique de Bordeaux
2016-2025
Electrophysiology and Heart Modeling Institute
2015-2024
Université de Bordeaux
2015-2024
Hôpital Cardiologique du Haut-Lévêque
2015-2020
Centre Hospitalier Universitaire de Bordeaux
2015-2020
Bordeaux Population Health
2016-2020
University of Auckland
2015-2018
Institut National de Recherche en Santé Publique
2017-2018
Bioengineering Center
2012-2018
Mapping data of human ventricular fibrillation (VF) are limited. We performed detailed mapping the activities underlying onset VF and targeted ablation in patients with structural cardiac abnormalities.
Background— The relationship between epicardial and body surface potentials defines the forward problem of electrocardiography. A robust formulation is instrumental to solving inverse problem, in which are computed from known potentials. Here, accuracy different models has been evaluated experimentally. Methods Results— Body were recorded simultaneously anesthetized closed-chest pigs (n=5) during sinus rhythm, endocardial ventricular pacing (65 records total). simulated recordings using...
Poor identification of electrical dyssynchrony is postulated to be a major factor contributing the low success rate for cardiac resynchronization therapy.The purpose this study was evaluate sensitivity body surface mapping and electrocardiographic imaging (ECGi) detect noninvasively.Langendorff-perfused pig hearts (n = 11) were suspended in human torso-shaped tank, with left bundle branch block (LBBB) induced through ablation. Recordings taken simultaneously from 108-electrode epicardial...
Background: Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there little systematic evaluation of its reliability. Methods: Torso and ventricular epicardial potentials were simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, endocardial pacing (70 records total). Body electrode positions...
Premature beats originating in clinically concealed areas of local early repolarization promote ventricular arrhythmias and sudden cardiac arrest.
Body surface potential maps (BSPMs) derived from multi-channel ECG recordings enable the detection and diagnosis of electrophysiological phenomena beyond standard 12-lead ECG. In this work, we developed two AI-based methods for automatic location electrodes used BSPM: a rapid method using specialized 3D Depth Sensing (DS) camera slower that can use any 2D camera. Both were validated on phantom model in 7 healthy volunteers. With model, both DS achieved an average localization error less than...
With increasing clinical use of Electrocardiographic Imaging (ECGI), it is imperative to understand the limits this technique. The objective study evaluate a potential-based ECGI approach for activation and repolarization mapping in sinus rhythm.Langendorff-perfused pig hearts were suspended human-shaped torso tank. Electrograms recorded with 108-electrode sock ECGs 256 electrodes embedded tank surface. Left bundle branch block (LBBB) was developed 4 through ablation, abnormalities another...
The electrocardiographic imaging inverse problem is ill-posed. Regularization has to be applied stabilize the and solve for a realistic solution. Here, we assess different regularization methods solving problem. In this study, i) zero order Tikhonov (ZOT) in conjunction with Method of Fundamental Solutions (MFS), ii) ZOT using Finite Element (FEM) iii) L1-Norm current density on heart surface combined FEM. Moreover, apply approaches computing optimal parameter, all based Generalized Singular...
Background Dispersion and gradients in repolarization have been associated with life‐threatening arrhythmias, but are difficult to quantify precisely from surface electrocardiography. The objective of this study was evaluate electrocardiographic imaging (ECGI) noninvasively detect repolarization‐based abnormalities. Methods Results Ex vivo data were obtained Langendorff‐perfused pig hearts (n=8) a human donor heart. Unipolar electrograms recorded simultaneously during sinus rhythm an...
Sudden cardiac death is often caused by ventricular arrhythmias driven reentry. Comprehensive characterization of the potential triggers and substrate in survivors sudden arrest has provided insights into trigger-substrate interaction leading to Previously, a “Triangle Arrhythmogenesis”, reflecting interactions between substrate, trigger modulating factors, been proposed reason about arrhythmia initiation. Here, we expand upon this concept separating characteristics their spatial temporal...
Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades. RT is typically determined by either Wyatt method or “alternative method,” which both consider UEG T-wave slope, but differently. Objective: To measure on UEG. Methods: Seven pig hearts surrounded an epicardial sock with 100 electrodes were Langendorff-perfused selective cannulation left anterior descending (LAD) coronary artery and...
BackgroundTorsades de pointes arrhythmia is a potentially lethal polymorphic ventricular tachyarrhythmia (pVT) in the setting of long QT syndrome. Arrhythmia susceptibility influenced by risk factors modifying repolarization.ObjectiveThe purpose this article was to characterize repolarization duration and heterogeneity relation pVT inducibility maintenance.MethodsSotalol infused regionally or globally isolated Langendorff blood–perfused pig hearts (N = 7) create time (RT) heterogeneities....
To investigatecardiac activation maps estimated using electrocardiographic imaging and to find methods reducing line-of-block (LoB) artifacts, while preserving real LoBs.Body surface potentials were computed for 137 simulated ventricular excitations. Subsequently, the inverse problem was solved obtain extracellular (EP) transmembrane voltages (TMV). From these, times (AT) four compared ground truth. This process evaluated with two cardiac mesh resolutions. Factors contributing LoB artifacts...
Electrocardiographic imaging (ECGi) reconstructs electrograms at the heart's surface using potentials recorded body's surface. This is called inverse problem of electrocardiography. study aimed to improve on current solution methods machine learning and deep frameworks. Electrocardiograms were simultaneously from pigs' ventricles their body surfaces. The Fully Connected Neural network (FCN), Long Short-term Memory (LSTM), Convolutional Network (CNN) used for constructing model. A method...
The inverse problem of electrocardiography is illposed.Errors in the model such as signal noise can impact accuracy reconstructed cardiac electrical activity.It currently not known how sensitive to processing techniques.To evaluate this, experimental data from a Langendorffperfused pig heart (n=1) suspended human-shaped torso-tank was used.Different methods were applied torso potentials recorded 128 electrodes embedded tank surface.Processing divided into three categories i) highfrequency...
Goal: To evaluate state-of-the-art signal processing methods for epicardial potential-based noninvasive electrocardiographic imaging reconstructions of single-site pacing data. Methods: Experimental data were obtained from two torso-tank setups in which Langendorff-perfused hearts (n = 4) suspended and potentials recorded simultaneously torso surfaces. 49 different applied to potentials, grouped as i) high-frequency noise removal (HFR) ii) baseline drift (BDR) iii) combined HFR+BDR. The...
Background Papillary muscles are an important source of ventricular tachycardia (VT). Yet little is known about the role right (RV) endocavity structure, moderator band (MB). The aim this study was to determine characteristics MB that may predispose arrhythmia substrates. Methods Ventricular wedge preparations with intact MBs were studied from humans (n=2) and sheep (n=15; 40-50 kg). RV endocardium optically mapped, electrical recordings measured along septum. S1S2 pacing free wall, MB, or...
Electroceuticals provide clinical solutions for a range of disorders including Parkinson's disease, cardiac arrythmias and are emerging as potential treatment option gastrointestinal disorders. However, pre-clinical investigations challenged by the large stimulation artifacts registered in bio-electrical recordings.A generalized framework capable isolating suppressing with minimal intervention was developed. Stimulation different pulse-parameters synthetic experimental signals were detected...
Ventricular (VT) and atrial (AT) tachycardias are some of the most common clinical cardiac arrhythmias. For ablation tachycardia substrates, two diagnosis methods used: invasive electroanatomical mapping for an accurate using electrograms (EGMs) acquired with intracardiac catheters, localized on surface mesh studied cavities; noninvasive electrocardiographic imaging (ECGi) a global view arrhythmia, EGMs mathematically reconstructed from body electrocardiograms 3-D cardio-thoracic meshes...
The excitable gap (EG), defined as the tissue between two subsequent wavefronts of depolarization, is critical for maintaining reentry that underlies deadly ventricular arrhythmias. EG in His-Purkinje Network (HPN) plays an important role maintenance electrical wave these
The effect of torso conductivity heterogeneities on the electrocardiographic imaging (ECGI) inverse problem solution is still subject debate. In this study we present a method to assess these heterogeneities. We use an anatomical model containing heart lungs bones and surfaces. bidomain solve it using finite element methods in order generate silico data taking into account add different noise levels body surface potentials for both homogenous heterogeneous conductivities. analyse...
Background: Non-invasive electrocardiographic imaging (ECGI) is a promising tool to provide high-resolution panoramic of cardiac electrical activity noninvasively from body surface potential measurements. Current experimental methods for ECGI validation are limited comparison with unipolar electrograms and the relatively low spatial resolution mapping arrays. We aim develop novel set up combining human shaped torso tank optical allowing reconstructions. Methods: Langendorff-perfused pig...