A5088769606- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Cardiovascular Effects of Exercise
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Neurological disorders and treatments
- Analog and Mixed-Signal Circuit Design
- Cardiac Arrest and Resuscitation
- Muscle activation and electromyography studies
- Cardiac Valve Diseases and Treatments
- Computer Graphics and Visualization Techniques
- Photoreceptor and optogenetics research
- Elasticity and Material Modeling
- Tensor decomposition and applications
Université de Bordeaux
2015-2025
Electrophysiology and Heart Modeling Institute
2016-2025
Institut de Mathématiques de Bordeaux
2014-2025
Institut Polytechnique de Bordeaux
2016-2025
Czech Academy of Sciences, Institute of Mathematics
2024
Institute of Mathematics and Informatics
2024
University Foundation
2024
Centre de Recherche Cardio-Thoracique de Bordeaux
2018-2022
Royal Canadian Mounted Police
2022
Inserm
2014-2021
Cardiac digital twins (Cardiac Digital Twin (CDT)s) of human electrophysiology (Electrophysiology (EP)) are replicas patient hearts derived from clinical data that match like-for-like all available observations. Due to their inherent predictive potential, CDTs show high promise as a complementary modality aiding in decision making and also the cost-effective, safe ethical testing novel EP device therapies. However, current workflows for both anatomical functional twinning phases within CDT...
Two- and three-dimensional models of cardiac excitability based on sodium channel kinetics can predict the adverse effects class I anti-arrhythmic drugs.
Aims Catheter ablation is an effective technique for terminating atrial arrhythmia. However, given a high fibrillation (AF) recurrence rate, optimal strategies have yet to be defined. Computer modelling can powerful aid but of fibrosis, major factor associated with AF, open question. Several groups proposed methodologies based on imaging data, no comparison determine which methodology best corroborates clinically observed reentrant behaviour has been performed. We examined several the method...
Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for disagreement. The purpose this study was to investigate whether variation in mapping may lead misinterpretation mechanism persistent AF.Simulations rotors and focal sources were performed estimate minimum number recording points required correctly identify AF mechanism. effects different types (action potentials unipolar or...
Being able to map a particular set of cardiac ventricles generic topologically equivalent representation has many applications, including facilitating comparison different hearts, as well mapping quantities and structures interest between them. In this paper we describe Universal Ventricular Coordinates (UVC), which can be used position within any biventricular heart. UVC comprise four unique coordinates that have chosen intuitive, defined, relevant for physiological descriptions. We how...
Mechanisms of atrial fibrillation (AF) initiation are incompletely understood. We hypothesized that rate-dependent changes (restitution) in action potential duration (APD) and activation latency central targets for clinical interventions induce AF. tested this hypothesis using experiments computer models.In 50 patients (20 persistent, 23 paroxysmal AF, 7 controls), we used monophasic catheters to define left APD restitution, latency, AF incidence from premature extrastimuli. Isoproterenol...
Atrial numerical modelling has generally represented the organ as either a surface or tissue with thickness. While models have significant computational advantages over models, they cannot fully capture propagation patterns seen in vivo, such dissociation of activity between endo- and epicardium. We introduce an intermediate representation, bilayer model human atria, which is capable recreating recorded activation patterns. simultaneously solved two monodomain problems by formalizing...
Pulmonary vein isolation (PVI) with radiofrequency ablation (RFA) is the cornerstone of atrial fibrillation (AF) therapy, but few strategies exist for when it fails. To guide RFA, phase singularity (PS) mapping locates reentrant electrical waves (rotors) that perpetuate AF. The goal this study was to test existing and develop new RFA terminating rotors identified PS mapping. It unsafe experimental in patients, so they were evaluated silico using a bilayer computer model human atria...
Premature beats originating in clinically concealed areas of local early repolarization promote ventricular arrhythmias and sudden cardiac arrest.
Recruitment of stretch-activated channels, one the mechanisms mechano-electric feedback, has been shown to influence stability scroll waves, waves that underlie reentrant arrhythmias. However, a comprehensive study examine effects recruitment channels with different reversal potentials and conductances on wave not undertaken; by which channel opening alters are also well understood. The goals this were test hypothesis affects differently depending potential conductance, uncover relevant...
Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset whom electrical isolation the pulmonary veins alone successful treatment strategy. It difficult to identify these because multitude factors affecting arrhythmia susceptibility and maintenance, individual contributions determine clinically. We hypothesised that combination vein (PV) electrophysiology body fibrosis driver location effectiveness (PVI). used bilayer...
Optogenetics-based defibrillation, a theoretical alternative to electrotherapy, involves expression of light-sensitive ion channels in the heart (via gene or cell therapy) and illumination cardiac surfaces implanted LED arrays) elicit light-induced activations. We used biophysically detailed human ventricular model determine whether such therapy could terminate fibrillation (VF) identify which combinations channel properties configurations would be effective. Defibrillation was successful...
Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of arrhythmogenic substrate incomplete. Alternans, beat-to-beat alternation in shape electrical signals, typically occurs at fast heart rates and leads to arrhythmia. However, atrial alternans have been observed slower pacing AF patients than controls, suggesting that increased vulnerability arrhythmia may be due proarrythmic influence these rates. As such, present a useful therapeutic target for treatment...
The mechanisms underlying atrial fibrillation (AF), the most common sustained cardiac rhythm disturbance, remain elusive. Atrial fibrosis plays an important role in development of AF and rotor dynamics. Both electrical wavelength (WL) degree change as progresses. However, their combined effect on core location remains unknown. aim this study was to analyze effects WL both fibrotic non-fibrotic atria. Three patient specific distributions (total content: 16.6%, 22.8% 19.2%) obtained from...
Sudden cardiac death is often caused by ventricular arrhythmias driven reentry. Comprehensive characterization of the potential triggers and substrate in survivors sudden arrest has provided insights into trigger-substrate interaction leading to Previously, a “Triangle Arrhythmogenesis”, reflecting interactions between substrate, trigger modulating factors, been proposed reason about arrhythmia initiation. Here, we expand upon this concept separating characteristics their spatial temporal...