A5054702228- Prostate Cancer Treatment and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- AI in cancer detection
- Renal cell carcinoma treatment
- Adrenal Hormones and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Hedgehog Signaling Pathway Studies
- Breast Lesions and Carcinomas
- Thyroid and Parathyroid Surgery
- Pancreatic and Hepatic Oncology Research
- IgG4-Related and Inflammatory Diseases
Columbia University Irving Medical Center
2017-2024
NewYork–Presbyterian Hospital
2017-2024
Columbia University
2018-2024
New York Hospital Queens
2017-2020
New York Proton Center
2019
Presbyterian Hospital
2018
Yale University
2012-2017
Loyola University Medical Center
2015-2017
University of Massachusetts Chan Medical School
2009-2015
University of British Columbia
2013
BACKGROUND An increase in thyroid cancers, predominantly papillary carcinoma (PTC), has been recently reported children. METHODS The histopathology of 28 consecutive PTCs from the northeast United States was reviewed. None patients (ages 6‐18 years; 20 females, 8 males) had significant exposure to radiation. Nucleic acid tumors tested for genetic abnormalities (n = 27). Negative results were reevaluated by targeted next‐generation sequencing. RESULTS Seven 27 (26%) neurotrophic tyrosine...
Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas. Examination pancreatic resection specimens from patients with AIP has shown that there are 2 subclasses this disease. However, no widely accepted pathologic classification scheme and clinical significance such remains to be established. In study, we revisited subclassification examine whether provides clinically prognostically meaningful information. We evaluated 29 AIP. Demographic, clinical, imaging data were...
When compared to other malignancies, the tumor microenvironment (TME) of primary and castration-resistant prostate cancer (CRPC) is relatively devoid immune infiltrates. While androgen deprivation therapy (ADT) induces a complex infiltrate in localized cancer, composition TME metastatic castration-sensitive (mCSPC), effects ADT treatments this context are poorly understood. Here, we perform comprehensive single-cell RNA sequencing (scRNA-seq) profiling sites from patients participating phase...
Abstract Purpose: Epigenetic events are a critical factor contributing to cancer development. The purpose of this study was identify tumor suppressor genes silenced by DNA methylation and histone deacetylation in non–small cell lung (NSCLC). Experimental Design: We used microarray analysis screen for genes. Results: identified Per1, core circadian gene, as candidate cancer. Although Per1 levels were high normal lung, its expression low large panel NSCLC patient samples lines. Forced lines...
The integration of whole slide imaging (WSI) and artificial intelligence (AI) with digital cytology has been growing gradually. Therefore, there is a need to evaluate the current state cytology. This study aimed determine landscape via survey conducted as part American Society Cytopathology (ASC) Digital Cytology White Paper Task Force. A 43 questions pertaining practices experiences WSI AI in both surgical pathology was created. sent members ASC, International Academy (IAC), Papanicolaou...
Finkelstein A, Levy G H, Hui P, Prasad Virk R, Chhieng D C, Carling T, Roman S Sosa J Udelsman Theoharis C & M L (2012) Histopathology 60, 1052–1059 Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct Aims: The mutation resulting in the production of an abnormal protein has emerged as most frequent genetic alteration papillary (PTCs). This study was aimed at identifying distinctive features tumours mutation. Methods results: Thirty‐four...
Although the existence of cancer stem cells (CSC) in adenoid cystic carcinoma (ACC) has been proposed, lack assays for their propagation and uncertainty about molecular markers prevented characterization. Our objective was to isolate CSC from ACC provide insight into signaling pathways that support propagation.To characterize them, we used ROCK inhibitor-supplemented cell culture, immunomagnetic sorting, andin vitro/in vivoassays viability tumorigenicity.We identified CD133-positive...
No AccessJournal of UrologyAdult Urology1 Aug 2020A Phase I Trial Intravesical Cabazitaxel, Gemcitabine and Cisplatin for the Treatment Nonmuscle Invasive bacillus Calmette-Guérin Unresponsive or Recurrent/Relapsing Urothelial Carcinoma BladderThis article is commented on by following:Editorial Comment Guarionex J. DeCastro, Wilson Sui, Jamie S. Pak, Shing M. Lee, Dara Holder, Max Kates, Renu K. Virk, Charles G. Drake, Christopher B. Anderson, Bridget James, Cory T. Abate-Shen, James...
Mitochondria provide the first line of defense against tumor-promoting effects oxidative stress. Here we show that prostate-specific homeoprotein NKX3.1 suppresses prostate cancer initiation by protecting mitochondria from Integrating analyses genetically engineered mouse models, human cells, and organotypic cultures, find that, in response to stress, is imported via chaperone protein HSPA9, where it regulates transcription mitochondrial-encoded electron transport chain (ETC) genes, thereby...
Background: The tall cell variant of papillary thyroid carcinoma is an aggressive subtype that generally presents as a large tumor in the advanced stage; however, little known about microcarcinoma (tumors measuring <1 cm). In this study, we compare (microTCV) with classic microcarcinomas to examine hypothesis that, despite small size, microTCV may be more than microcarcinoma. Methods: We identified 27 patients and compared their clinicopathologic features BRAFV600E mutational status matched...
Metastatic tumors to the thyroid are relatively uncommon, constituting less than 1% of all malignancies. Fine-needle aspiration nodules is a reliable technique diagnose primary lesions with excellent sensitivity and specificity; however, cytologic diagnosis metastatic can be challenging, particularly if prior clinical history not available. Clinical presentation very much similar that tumors. Although renal cell carcinoma appears most common secondary tumor thyroid, any metastasize breast,...
ABSTRACT Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative expression profiling data from human tumors, we demonstrate reciprocal relationship between and status NKX3.1 homeobox gene associated cancer initiation. We find initiation aged Nkx3.1 mutant mice correlates enrichment specific immune populations increased...
Background The aim of this study was to evaluate the potential use UroVysion® fluorescent in situ hybridization test (U‐FISH) stratify risk urothelial carcinoma (UC) patients with a diagnosis “atypical cells” (AUC) urinary tract cytology (UTCy). Methods Using histologic UC and respectively high grade (HGUC) within 12 months index UTCy as reference standard, we determined sensitivity, specificity, positive predictive value (PPV), negative (NPV), accuracy U‐FISH for AUC diagnosed 2008 2014....
Fine-needle aspiration (FNA) is the most accurate and cost-effective method for evaluating thyroid nodules. However, FNA-induced secondary changes completely replacing tumors (vanishing tumors) may create a novel problem. In this study, we highlight diagnostic management issues associated with unintended consequences of ultrasonography (US)-guided FNA.Fourteen glands (11 women 3 men, ages 33-64 years) vanishing were prospectively identified between 2009 2012 upon surgical resection. Cytology...