A5058364311- AI in cancer detection
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Adhesion, Friction, and Surface Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging and Pathology Studies
- Gallbladder and Bile Duct Disorders
- Semiconductor materials and devices
- Gastric Cancer Management and Outcomes
- Cervical Cancer and HPV Research
- Metastasis and carcinoma case studies
- Synthesis and properties of polymers
- Tribology and Wear Analysis
- Cancer Genomics and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Liver Diseases and Immunity
University of Michigan
2023-2025
Michigan Medicine
2023-2024
University of Chicago
2020-2023
University of Chicago Medical Center
2023
Western University
1998-2017
Riverside Community Hospital
2017
University of California, Riverside
2017
Western Michigan University
2017
Stryker (United States)
2017
University of California, Irvine
2010
The Cancer Genome Atlas (TCGA) is one of the largest biorepositories digital histology. Deep learning (DL) models have been trained on TCGA to predict numerous features directly from histology, including survival, gene expression patterns, and driver mutations. However, we demonstrate that these vary substantially across tissue submitting sites in for over 3,000 patients with six cancer subtypes. Additionally, show histologic image differences between can easily be identified DL. Site...
Eosinophilic renal neoplasms have a wide spectrum of histologic presentations, and several studies demonstrated subtype cell carcinomas (RCCs) associated with the tuberous sclerosis complex (TSC)/mammalian target rapamycin pathway. A review our institutional archives led to identification 18 cases eosinophilic tumors unusual morphology. Immunohistochemical analysis that these could be separated into 3 groups: group 1 had solid architecture morphology similar chromophobe RCC but was negative...
Abstract Background TP53 mutation is present in about 50.8% of lung adenocarcinomas, frequently combination with other genetic alterations. However, a rare subset harbors the alone. Methods Next‐generation sequencing was performed 844 adenocarcinomas diagnosed by fine needle aspiration. Fourteen cases (1.7%) showed isolated alteration and were subjected to comprehensive analysis. Results The average age at diagnosis 65.7 years (range 48–79); 9 males 5 females. All smokers an pack‐year 40.7...
The integration of whole slide imaging (WSI) and artificial intelligence (AI) with digital cytology has been growing gradually. Therefore, there is a need to evaluate the current state cytology. This study aimed determine landscape via survey conducted as part American Society Cytopathology (ASC) Digital Cytology White Paper Task Force. A 43 questions pertaining practices experiences WSI AI in both surgical pathology was created. sent members ASC, International Academy (IAC), Papanicolaou...
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories digital histology. Deep learning (DL) models have been trained on TCGA to predict numerous features directly from histology, including survival, gene expression patterns, and driver mutations. However, we demonstrate that these vary substantially across tissue submitting sites in for over 3,000 patients with six cancer subtypes. Additionally, show histologic image differences between can easily be identified DL....
Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy resection specimens pleural MM.Histologic percentage epithelioid morphology, presence or absence necrosis were compared 429 biopsies MM from 19 institutions.Histologic subtype was concordant 81% cases (κ = 0.58). When with specimens, morphology at had a positive predictive value (PPV) 78.9% negative (NPV)...
Abstract “Centering in a focus round and neat, Let all your rays of information meet.” (Cowper, Conversation, 1781) Just over two years ago, the guide hall newly created Cold Neutron Research Facility (CNRF) at NIST reactor was inaugurated. This is currently only cold source U.S. research which serves large number scientific instruments.1 While most instruments installed facility are spectrometers for neutron scattering studies covering wide range endeavors, new have been designed...
ABSTRACT Introduction/Objective Biliary brushing cytology (BB) to detect cholangiocarcinoma (CCA) is integral in the surveillance of patients with primary sclerosing cholangitis (PSC). Since reactive changes can mimic carcinoma, indeterminant results are frequent. Fluorescence situ hybridization (FISH) using UroVysion probe set has been advocated enhance detection CCA. This study evaluates performance FISH for detecting CCA and without PSC. Materials Methods A query our pathology database...
Abstract This study is of autopsy data for potential validation as to whether increased weights the lungs support toxic effects drugs cause death. retrospective compared from 133 deaths resulting with previously reported normal lung (Toxicol Mech Methods, 22, 2012, 159; Am J Forensic Med Pathol 33, 368). The and their standard errors were used in a two‐sample independent t‐test comparing average drug‐related death weight control weights. To account multiple comparisons, Bonferroni‐adjusted...
Humidity effects on the relaxation of molecularly thin lubricant films were studied via examining bonded fraction and surface energy fresh dip-coated perfluoropolyether (PFPE) monolayer as functions elapsed time. The polar Zdol was found to monotonically decrease with time, which indicates reorganization molecular structure conformation. Characteristic time obtained by analyzing this time-dependent behavior Kohlrausch-Williams-Watts (KWW) function. Molecular dynamics simulation a bead-spring...
Abstract Most patients with thoracic endometriosis present catamenial pneumothorax, a rare condition in which recurrent episodes occur within 72 h before or after the start of menstruation. We report case presenting bloody pleural effusions without pneumothorax diagnosed on fluid cytology. describe cytomorphology and immunoprofile discuss differential diagnoses, including neoplastic processes. also highlight importance communication clinicians for timeliness diagnosis treatment, especially...
Abstract Background This study aimed to investigate if peritoneal mesothelioma (PM) patients with germline mutations (GM) have distinct surgical characteristics when compared those without GM. Methods PM were selected from an ongoing prospective that conducts testing of 82 susceptibility genes. Germline status was correlated data obtained a prospectively collected database using univariate, multivariate, and receiver operating characteristic (ROC) analyses. Results Out 88 enrolled between...
<b><i>Background:</i></b> Fine needle aspiration (FNA) of renal masses can distinguish between benign and malignant neoplasms in 73–94% cases. Previous studies suggested the correct subclassification cell carcinomas (RCCs) by cytomorphology be achieved up to 80% However, as RCCs become increasingly subclassified molecular signatures, based on cytology alone is difficult. <b><i>Design:</i></b> Two FNA passes (2 stained with Diff-Quik® 2...
In this paper, humidity effects on the relaxation of perfluoropolyether (PFPE) films were examined by bonded fraction and surface energy measurements. MD simulation with a bead-spring model was also performed. The calculated time for functional PFPE molecule in film found to be shorter at high humidity, which is consistent experimental results.
Electromechanical reshaping (EMR) of cartilage is a promising noninvasive technique with potential for broad application in reconstructive surgery. EMR involves applying direct current electrical fields to localized stress regions and then initiating series oxidation-reduction reactions, thus effecting shape change. Previous studies have focused on macroscopic structural measurements the change effect or monitoring flow. Only limited investigation changes tissue at histologic level been...