A5051708548- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- AI in cancer detection
- Pregnancy and preeclampsia studies
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Genital Health and Disease
- Tumors and Oncological Cases
- Preterm Birth and Chorioamnionitis
- Gestational Trophoblastic Disease Studies
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Maternal and fetal healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Single-cell and spatial transcriptomics
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Estrogen and related hormone effects
- Birth, Development, and Health
University of Michigan
2016-2025
Michigan Medicine
1999-2024
Virginia Commonwealth University
2020
Trinity Health Ann Arbor Hospital
2006
Sequenom (United States)
2005
Henry Ford Hospital
2005
Wayne State University
2005
Albert Einstein College of Medicine
2005
University of Toronto
2005
Oregon Health & Science University
2003
Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes, including pre-eclampsia, particularly in association antiphospholipid antibody syndrome (APS). While significant placental abnormalities are expected less known about how activity and APS affect the placenta. We describe pathology from a population pregnancies, several which were complicated by APS-related thromboses, pre-eclampsia other complications developed. performed standard...
The authors undertook a prospective study of 30 patients undergoing halothane anesthesia for coronary-artery revascularization to ascertain which clinically monitored hemodynamic variables--or combination variables--associated with myocardial oxygen supply and demand best predict ischemia. Simultaneous recordings electrocardiogram (lead II V5), systemic, central venous, pulmonary artery, artery occluded pressures were analyzed correlation ischemic episodes. Ischemia occurred significant...
Despite a significant decrease in the incidence and mortality of cervical carcinoma United States, an estimated 12,200 women will be diagnosed with disease 2010, 4210 expected deaths. 1 High-risk groups include without access to health care those who have immigrated States from countries where cancer screening is not routinely performed. 2Because cytology current method for early detection this neoplasm, purpose these guidelines provide direction evaluation management cytology.These...
This paper presents a domain-specific automated image analysis framework for the detection of pre-cancerous and cancerous lesions uterine cervix. Our proposed departs from previous methods in that we include diagnostic features probabilistic manner using conditional random fields. Likewise, provide novel window-based performance assessment scheme 2D which addresses intrinsic problem misalignment. Image regions corresponding to different tissue types are indentified extraction anatomical...
Abstract A second trimester fetal demise followed influenza-like illness in early pregnancy. Influenza virus (H1N1) was identified maternal and tissue, confirming transplacental passage. These findings suggested a causal relationship between exposure demise. Management of future influenza outbreaks should include evaluation products conception associated with loss.
Protein disulfide isomerase (PDI) is an oxidoreductase that overexpressed in several cancers. PDI family members (PDIs) play a role various diseases including cancer. Select PDIs were reported as useful markers other cancers but their expression ovarian cancer has not been thoroughly assessed. We sought to evaluate the of PDI, PDIA6, PDIR, ERp57, ERp72 and AGR3 patient samples examine prognostic significance.TMA from 415 tissues collected three centers (UM, USC, KCCRI) used assess levels...
We assayed for the presence of human papilloma virus (HPV) DNA in serum and/or peripheral blood fraction (PBF) individuals with cervical, head/neck, or bladder cancer due to schistosomiasis. Using mass spectroscopy coupled competitive PCR, HPV was detected at individual molecule level by using “MassARRAY” assays. The resultant sensitivity superior real-time fluorescent PCR-based assays, while specificity maintained. Our principal findings were: ( i ) Virtually all tested cervical cancers and...
Cervical intraepithelial neoplasia (CIN) exhibits certain morphologic features that can be identified during a colposcopic exam. Immature metaplastic and dysplastic cervical squamous epithelia turn white after application of acetic acid the The whitening process occurs visually over several minutes subjectively helps to discriminate between normal tissue. Digital imaging technologies enable us assist physician in analyzing acetowhite (acetic-acid-induced) lesions fully automatic way. We...
Abstract Epithelial ovarian cancer (EOC) is a leading cause of cancer-related mortality in the United States due to late-stage disease at diagnosis. Overexpression GRP78 and PDI following endoplasmic reticulum (ER) stress activation unfolded protein response (UPR) promote growth invasion cancer. To identify novel prognostic biomarkers EOC, here we determined expression ER stress-associated proteins (GRP78, ATF6 PERK) correlated with clinical outcome EOC. Tissue microarray (TMA) samples from...
Abstract Polycystic ovary syndrome (PCOS) is a common condition of reproductive-aged women. In well-validated sheep model PCOS, testosterone (T) treatment pregnant ewes culminated in placental insufficiency and intrauterine growth restriction offspring. The purpose this study was to explore specific mechanisms by which T excess compromises function early, mid, late gestation. Pregnant Suffolk received propionate 100 mg intramuscularly or control vehicle twice weekly from gestational days...
We report the case of a 61-year-old woman with persistent thyrotoxicosis for 7 years despite low thyroidal radioiodine uptake and methimazole treatment. Her initial 123I whole-body scan (WBS) was read as negative. Upon evaluation in our institution, she remained hyperthyroid after discontinuation methimazole. Repeat WBS SPECT/CT revealed 24-hour (RAIU = 2%) intensely focal large heterogeneous left pelvic mass, consistent adnexal struma ovarii. Resection this mass confirmed benign This...
The human uterus is a complex and dynamic organ whose lining grows, remodels, regenerates in every menstrual cycle or upon tissue damage. Here we applied single-cell RNA sequencing to profile more the 50,000 uterine cells from both endometrium myometrium of 5 healthy premenopausal individuals, jointly analyzed data with previously published dataset 15 subjects. resulting normal cell atlas contains than 167K representing lymphatic endothelium, blood stromal, ciliated epithelium, unciliated...
The human uterus is a complex and dynamic organ whose lining grows, remodels, regenerates every menstrual cycle or upon tissue damage. Here, we applied single-cell RNA sequencing to profile more the 50,000 uterine cells from both endometrium myometrium of five healthy premenopausal individuals, jointly analyzed data with previously published dataset 15 subjects. resulting normal cell atlas contains than 167K cells, representing lymphatic endothelium, blood stromal, ciliated epithelium,...
Abstract Crane scheduling problems are introduced together with a descriptive general model. In particular, crane one operation per job investigated when arrival patterns static or dynamic and the processing times arbitrary.
Objectives Despite poor reproducibility for measuring vulvar cancer depth, 1-mm or greater invasion triggers lymphadenectomy small tumors. Previous literature suggests that depth from the nearest dysplastic rete peg (alternative method) rather than highest dermal papilla (conventional may be acceptable. Methods Pathologic staging and follow-up information were recorded 100 pT1 squamous cell carcinoma (SCC) resected 1990 to 2019. Conventional alternative gross/clinical size, size of invasive...
Squamous cell carcinoma of the vulva can arise through 2 pathways: human papillomavirus (HPV)-dependent high-grade squamous intraepithelial lesions (previously termed usual vulvar neoplasia) or HPV-independent (differentiated neoplasia, dVIN). Distinguishing between types be clinically and histologically difficult. A subset with superimposed chronic inflammation mimicking dVIN has recently been reported; p53 shows characteristic mid-epithelial staining (with basal sparing) in such cases. The...