A5047988040- DNA Repair Mechanisms
- Metal complexes synthesis and properties
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Trace Elements in Health
- Genital Health and Disease
- Uterine Myomas and Treatments
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- CRISPR and Genetic Engineering
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Ferroptosis and cancer prognosis
- Endometriosis Research and Treatment
- Gestational Trophoblastic Disease Studies
- Colorectal and Anal Carcinomas
- interferon and immune responses
- Viral-associated cancers and disorders
University of Michigan
2016-2025
Michigan Medicine
2016-2025
Prince of Wales Hospital
2024
Chinese University of Hong Kong
2024
S.P.E.C.I.E.S.
2023
Michigan Center for Translational Pathology
2021-2022
Roche (Switzerland)
2022
Beaumont Health
2021
University of Pittsburgh Medical Center
2021
Virginia Commonwealth University
2020
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human types the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune checkpoint. We showed that genetic deficiency of resulted activation fetal resorption allogeneic pregnancy models. Analogously, contributed to MPA/DMBA-induced breast progression, accompanied by CD8
TFEB is overexpressed in -rearranged renal cell carcinomas as well tumors with amplifications of at 6p21.1. As recent literature suggests that 6p21.1 amplification behave more aggressively than those rearrangements , we compared relative gene expression these tumors. This study included 37 -altered tumors: 15 6p21.1-amplified and 22 (including 5 cases from The Cancer Genome Atlas data set). status was verified using a combination fluorescent situ hybridization (n=27) or comprehensive...
Abstract High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer subtype. PARP inhibitors (PARPi) have become mainstay of HGSC-targeted therapy, given that these tumors are driven by a high degree genomic instability (GI) homologous recombination (HR) defects. Nonetheless, approximately 30% patients initially respond to treatment, ultimately relapsing with resistant disease. Thus, despite recent advances in drug development an increased understanding genetic...
Our recent study revealed recurrent chromosomal losses and somatic mutations of genes in the Hippo pathway mucinous tubular spindle cell carcinoma (MTSCC). Here, we performed an integrative analysis 907 renal (RCC) samples (combined from The Cancer Genome Atlas in-house studies) Knepper data set microdissected rat nephrons. We identified VSTM2A IRX5 as novel cancer-specific lineage-specific biomarkers MTSCC. then assessed their expression by RNA situ hybridization (ISH) 113 tumors, including...
The morphologic features of uterine smooth muscle tumors (USMTs) are subject to interobserver variability and complicated by consideration fumarate hydratase deficiency (FHd) other subtypes, with difficult cases occasionally diagnosed as tumor uncertain malignant potential (STUMP). We compare immunohistochemical findings detailed analysis 45 USMTs 4 fellowship-trained gynecologic pathologists comprehensive molecular analysis, focusing on FHd leiomyomas (n=15), compared a variety overlapping...
“Mixed endometrioid adenocarcinoma and adenosarcoma” is a recently described malignancy of the uterus ovary characterized by discrete components Mullerian adenosarcoma typically low-grade adenocarcinoma. Its molecular biology, natural history, proper classification remain uncertain. We analyzed clinicopathologic data performed comparative analysis on adenocarcinomatous adenosarcomatous 14 tumors using 168-gene next-generation sequencing panel (n=11) MSK-IMPACT assay (n=3). Thirteen were...
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by germline mutations in the FH gene, associated with increased incidence of leiomyomas a potentially aggressive variant (HLRCC-associated RCC). Absent immunohistochemical expression fumarate hydratase (FH) has previously been used to diagnose HLRCC-associated RCC, but staining not standard practice. We performed immunohistochemistry (IHC) on whole sections from consecutive cutaneous our archives evaluate for both succinate...
Abstract Genomic instability (GI) predisposes cells to malignant transformation, however the molecular mechanisms that allow for propagation of with a high degree genomic remain unclear. Here we report miR-181a is able transform fallopian tube secretory epithelial through inhibition RB1 and stimulator-of-interferon-genes (STING) propagate GI. MiR-181a targeting leads profound nuclear defects GI generating aberrant cytoplasmic DNA, simultaneous mediated STING allows bypass interferon cell...
Steroid cell tumors (SCTs) of the ovary are rare and understudied, as such, uncertainties remain about their malignant potential, well clinicopathologic predictors patient outcome. Based on a multi-institutional cohort cases, we present findings from largest study SCT reported to date. Clinicopathologic data were documented 115 cases that assembled 17 institutions. The median age was 55 years (range: 9 84). When measured, preoperative androgen levels elevated in 84.2% (48/57) patients. A...
Background The Paris System (TPS) introduced diagnostic criteria for urine cytology to improve reproducibility among pathologists. Thus far, most studies have investigated application of TPS on lower urinary tract specimens. Also, it is unclear which cytologic features are predictive malignancy, particularly in the upper tract. We evaluate concordance rates preoperative specimens before and after with surgical resections assess associated malignancy. Design 54 high‐ low‐grade urothelial...