A5014863045- High-Temperature Coating Behaviors
- Aluminum Alloys Composites Properties
- Metal and Thin Film Mechanics
- High-Velocity Impact and Material Behavior
- Cancer-related Molecular Pathways
- Advanced Welding Techniques Analysis
- Forest, Soil, and Plant Ecology in China
- Energetic Materials and Combustion
- Remote Sensing and Land Use
- Welding Techniques and Residual Stresses
- Magnesium Alloys: Properties and Applications
- Plant Water Relations and Carbon Dynamics
- Additive Manufacturing Materials and Processes
- Aluminum Alloy Microstructure Properties
- Environmental and Agricultural Sciences
- Acute Myeloid Leukemia Research
- High Entropy Alloys Studies
- Adipose Tissue and Metabolism
- Smart Grid and Power Systems
- Wind Turbine Control Systems
- HVDC Systems and Fault Protection
- Advanced ceramic materials synthesis
- Electromagnetic Launch and Propulsion Technology
- Inertial Sensor and Navigation
- Gear and Bearing Dynamics Analysis
Panzhihua Central Hospital
2024
University of Michigan
2021-2024
First Affiliated Hospital of Wannan Medical College
2023-2024
Wannan Medical College
2024
Michigan Center for Translational Pathology
2021-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
Chinese Academy of Forestry
2012-2023
Princess Margaret Cancer Centre
2014-2023
Institute of Crop Sciences
2013-2023
Chinese Academy of Agricultural Sciences
2013-2023
Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, lipid derived from avocado fruit, as novel compound with cytotoxic activity in AML. Avocatin B reduced human primary AML cell viability without effect on normal peripheral blood stem cells. Functional assays demonstrated selectivity toward progenitor and cells effects hematopoietic Mechanistic investigations indicated that...
Stalk rot caused by Fusarium verticillioides (Fv) is one of the most destructive diseases in maize production. The defence response root system to Fv invasion important for plant growth and development. Dissection cell type-specific infection its underlying transcription regulatory networks will aid understanding mechanism roots invasion. Here, we reported transcriptomes 29 217 single cells derived from tips two inbred lines inoculated with mock condition, identified seven major types 21...
The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated macrophages (TAMs) play a key role in tumor Therefore, modulating function tumor-associated potential therapeutic strategy to control We found vivo experiments that activation STING inhibited CRC metastasis model mice and affected macrophage phenotype microenvironment. Mechanistically, affects TAM polarization regulates through IRG1. And activates IRG1 promote nuclear translocation TFEB, affecting ability...
Article Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy Adult Sheep Offspring Wei Ge 1, Qiurong Wang 2,3, Jun Tao 4, Stephen P. Ford 5,†, Guo 6,7, Xiaoming 8,* Ren 2,3,* 1 Department of General Practice, Xijing Hospital, Air Force Medical University, Xi’an 710032, China 2 Cardiology, Zhongshan Hospital Fudan Shanghai Institute Cardiovascular Diseases, 200032, 3 National Clinical Research Center for Interventional Medicine, 4...
A new technique for wall conditioning that will be especially useful future larger superconducting tokamaks, such as ITER, has been successfully developed and encouraging results have obtained. Solid carborane powder, which is non-toxic non-explosive, was used. Pulsed RF plasma produced by a non-Faraday shielding antenna with power of 10 kW. The ion temperature about 2 keV toroidal magnetic field 1.8 T pressure 3 × 10-1 Pa. Energetic ions broke up the molecules, resulting boron struck were...
Abstract Background and Aim Helicobacter pylori infection is linked to various gastrointestinal conditions, such as chronic active gastritis, peptic ulcers, gastric cancer. Traditional treatment options encounter difficulties due antibiotic resistance adverse effects. Therefore, the aim of this study was explore effectiveness a new plan that combines vonoprazan (VPZ), amoxicillin, bismuth for eradication H. . Methods A total 600 patients infected with were recruited multicenter randomized...
Abstract A novel compact multiband printed slot antenna fed by a asymmetric coplanar strip for applications is presented. The prototype on substrate of dielectric constant 4.4 with an overall dimension only 31 × 15 mm 2 proposed wireless local area network (WLAN) in the 2.4–2.48 GHz, 5.15–5.35 and 5.725–5.825 GHz frequency range. design, simple feeding technique, compactness make it easy integration into circuit boards. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 3080–3083,...
X-linked adrenoleukodystrophy (X-ALD) is a complex disorder with variable expressivity that affects the nervous, adrenocortical and male reproductive systems. Although ABCD1 mutations are known to provide genetic basis for X-ALD, its pathogenesis not fully elucidated. While elevated very long chain fatty acid (VLCFA) levels in blood reduced VLCFA catabolic activity cultured fibroblasts biomarkers used identify mutation carriers, roles peroxisomal lipid metabolism play disease etiology...
A large body of evidence supports a central role TLR5 and its natural ligand, flagellin, in Crohn's disease (CD), with the precise mechanism(s) still unresolved.We investigated flagellin/TLR5 SAMP1/YitFc (SAMP) mice, spontaneous model disease-like ileitis.Ileal Tlr5 serum antiflagellin IgG antibodies were increased SAMP before onset inflammation during established disease; these trends abrogated absence colonizing commensal bacteria. Irradiated receiving either wild-type (AKR) or bone marrow...
Abstract Introduction Zellweger spectrum disorder (PBD-ZSD) is a disease continuum caused by mutations in subset of PEX genes required for normal peroxisome assembly and function. They highlight the importance peroxisomes development functions central nervous system, liver, other organs. To date, underlying bases cell-type specificity are not fully elucidated. Methods Primary skin fibroblasts from seven PBD-ZSD patients with biallelic PEX1 , PEX10 PEX12 or PEX26 three healthy donors were...
In this paper, the effects of temperature and strain rate on plastic deformation behavior 5052 aluminum alloy were investigated by quasi-static tensile test split Hopkinson pressure bar (SHPB) experiments. Meanwhile, stress-strain relations obtained through these experiments employed for calibrating Johnson-Cook (J-C) flow constitutive parameters alloy. The results show that sensitivity is insignificant in range 0.001s -1 ~3000s , while has a great effect material behavior. experimental data...
Abstract Background The prognostic value of cytokeratin 19 fragment (CYFRA 21 − 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored. Methods In this study, 983 primary NSCLC from January 2016 December 2019 were retrospectively reviewed. Finally, 117 EGFR 37 mutation included CYFRA 1 also identified. Results age, smoking history the Eastern Corporative Oncology Group (ECOG) performance scores...
PknD is one of the eleven eukaryotic-like serine/threonine protein kinases (STPKs) Mycobacterium tuberculosis (Mtb). In vitro phosphorylation assays with active recombinant showed that intracellular NAD+-dependent malate dehydrogenase (MDH) a substrate this kinase. MDH, an energy-supplying enzyme, catalyzes interconversion and oxaloacetate plays crucial roles in several metabolic pathways including citric acid cycle. The site was identified on threonine residues inhibited MDH activity....
The stress and motion state of droplet in MIG welding with alternating longitudinal magnetic field were analyzed, the impact on transfer studied by high-speed video camera. results show that is spherical approximately to molten pool along wire axis without external field. When was introduced into process, rotate around clockwise counter-clockwise alternately. Shape became flat direction deviated from under action As exciting current increased, extent deviation increases. too large (I...